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Activity of dorsal raphe serotonin neurons in mice with differential TAAR1 function
No full textThis dissertation examines how TAAR1 functionality influences dorsal raphe serotonin neuron activity, glutamatergic inputs, and methamphetamine (MA) intake in mice with differential TAAR1 function and sensitivity to the rewarding and aversive effects of MA
Discovery and characterization of a novel KATP channel pharmacochaperone
No full textMy work resulted in the discovery of a novel KATP channel pharmacochaperone, Aekatperone, through AI-driven virtual screening of the drug binding site using the Cryo-EM structure of the KATP channel. Additionally, I functionally characterized the effects of Aekatperone on novel trafficking mutations associated with congenital hyperinsulinism
PEAR1 mutations in acute myeloid leukemia
No full textThis thesis investigates Acute Myeloid Leukemia, focusing on the PEAR1 gene and receptor, analyzed using the IL-3 withdrawal assay and other techniques. All bench work shown in the writing was done in the Jeff Tyner lab.</b
