OHSU Digital Collections (Oregon Health and Science University)
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Public health nursing
No full textFor several years, I have been increasingly interested in learning the work of Public Health officials, now as I am nearing the end of my short time as a student nurse, I am anxious to further my ever unsatisfied knowledge of their work. This thesis, through my interest in these different topics or problems under Public Health, is an endeavor to stimulate their interest in their work and allow them to see the rapid growth and splendid development
Missing pages
No full textThis digital artwork highlights the deficiencies in medical education, the racial and gender biases that contribute to health disparities, and the neglect of patients' emotional experiences. This project was created as part of Narrative Competence for Health Professionals, an interprofessional education course. </p
Shadow
No full textThis artwork explores the concept of "Shadow," representing the complex nature of human identity shaped by individual experiences. This project was created as part of Narrative Competence for Health Professionals, an interprofessional education course. </p
The avoidant manager
No full text A drawing illustrating the author's personal mental health journey. This project was created as part of Narrative Competence for Health Professionals, an interprofessional education course. </p
Small biologic reagents for cancer detection, monitoring and improved treatment outcomes
No full textThis dissertation aims to present technological and therapeutic innovations to meet clinical needs in the field of cancer detection and treatment. The presented work revolves around small biologics, essentially peptides, that have been leverage to develop non-invasive liquid biopsy applications. The second and last chapter of this research focus on therapeutic application, using peptide therapeutic to mitigate age-related dysfunctions, as well as metastatic and therapy-induced tissue disorders
Examining biopsychosocial risk factors for adulthood depression: investigating the role of childhood trauma, adolescent reward-related neurocircuitry, and reward learning
No full textDepression rates are climbing, and the etiology is multi-factorial. The overarching goal of the present work is to examine specific neurobiological and psychosocial risk factors across adolescence to young adulthood to improve our understanding of factors that may contribute to psychopathology risk
New populations of neurons reveal novel mechanisms of cell death and astrocyte-dependent neurite pruning
Get PDFDuring animal development, nervous systems over-wire and then refine to shape precise neuronal circuitry. This developmental neuronal remodeling, observed across evolution, involves the selective pruning of synapses, neurites or whole neurons, to refine circuit connectivity, however the molecular mechanisms that drive this process have proven to be complex and diverse. To untangle this complexity, I performed a large-scale screen in Drosophila to discover new mechanisms of developmental neuronal remodeling. Here I describe two newly-identified populations of Drosophila neurons, tracked temporally at single-cell resolution, that remodel in a novel manner. The neurons—which we refer to as the Beat-Va lateral (Beat-VaL) and Beat-Va medial (Beat-VaM) populations—undergo cell local pruning and cell death, respectively. Beat-VaL cells use hormone signaling, caspase activation and Hox genes to execute cell death. This is the first time that both hormone signaling and Hox genes have been shown to be necessary for neuronal cell death in the same population of neurons. In the Beat-VaM population, astrocytes are necessary for the fragmentation step of remodeling. This is the first-time astrocytes specifically have been implicated in a non-redundant fashion in neuronal fragmentation in the fly. These findings demonstrate 1) a new mechanism for cell death that relies on intersectional Hox gene and hormone receptor expression 2) a novel mechanism for neurite pruning involving astrocytes and 3) that astrocytes play unique and crucial roles at specific stages during the remodeling process. Furthermore, I present preliminary data on three other populations of neurons that remodel during metamorphosis, and which could be informative in future studies