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    History of the Doernbecher Children's Hospital Guild

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    This paper was written by Burt Brown Barker who was the second president of the Doernbecher Children's Hospital Guild starting in 1943. He had previously served as both director and chairman. While his intended purpose for writing this detailed history of the Guild is not known, he provides a narrative of the creation of the Guild and an account of its good works. This includes a brief history of how Frank S. Doernbecher amassed his wealth, his decision to bequeath $200,000 to charity to benefit Oregonians, and how his children, Ada and Edward Doernbecher, acted as trustees and decided the money should be used to build a hospital for children. Barker describes the Guild's early organizational meetings in 1924 and lists many of the attendees who set about the task of raising the additional funds needed to open, run, and maintain Doernbecher Memorial Children's Hospital. There are excerpts of the Guild's constitution included in this report as well as rosters of early events, lists of early donations and how they were used, and notes of collaborations with many charitable groups. In one section, Barker proudly shares a report he requested from medical director Dr. Charles N. Holman, which includes three case studies that demonstrate Doernbecher's application of the latest medical concepts. The last few paragraphs provide the names of the dedicated personnel both at the Guild and at the hospital itself.Additionally, Barker explains that in 1923, prior to the Guild's formation, the Rotary Club had already decided to establish "The Rotary Crippled Children's Fund" for the treatment of sick and disabled children. He elaborates by describing a Rotary Club fundraiser that was an "old-fashioned minstrel show" which included racist imagery

    Assessment of junior faculty development in pediatrics

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    The assessment of junior faculty development at Oregon Health & Science University (OHSU) highlights the challenges new faculty face in accessing effective development resources within the Department of Pediatrics (DoP). Despite offering various programs aimed at enhancing leadership, teaching, research, and clinical skills, the absence of a centralized access system, coupled with barriers such as limited time, lack of program awareness, and scheduling conflicts, impedes engagement. Additionally, the lack of a systematic feedback loop makes it difficult to tailor these resources to faculty needs. To address these issues, the assessment recommends implementing structured feedback mechanisms, introducing a faculty development portal early in onboarding, creating a development roadmap, integrating growth discussions into annual reviews, and providing flexible participation options. By adopting these strategies, the department seeks to foster faculty growth, satisfaction, and retention, ultimately enhancing patient care and educational outcomes

    Evaluation of metabolic activity diffusion imaging in resected human glioma

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    Representing the first study to employ Metabolic Activity Diffusion Imaging (MADI) within human brain cancer, this thesis serves as a demonstration of MADI's ability to probe cellular metabolism and cellular properties to evaluate tumor progression status in resected human gliomas. Three goals were pursued: (i) MADI's ability to differentiate normal tissue, tumor progression, and pseudoprogression, (ii) how MADI compares to a common metabolic activity imager FDG-PET, and (iii) identification of limitations and weaknesses in the current MADI approach

    Sparking joy: enhancing emotional agency, engagement, and reducing burnout in the pediatric ICU

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    This Capstone builds on earlier efforts at OHSU by applying the Institute for Healthcare Improvement’s Joy in Work (JiW) framework to strengthen psychological safety and connection among providers. This third-phase project evaluated two interventions: a weekly gratitude moment and a structured survey on the sign-out process and explored additional themes of contributors and barrier to joy in the PICU. Qualitative data review highlighted four themes: communication challenges, desire for team cohesion, need for safe feedback, and the importance of visible progress. Recommendations include standardizing communication, fostering peer connection, using structured tools like DESC and I-PASS, and co-designing small, visible improvements to sustain engagement

    Deep learning frameworks for electron microscopy image analysis with sparse labels

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    This thesis presents a suite of deep learning frameworks designed to address key challenges in the analysis of Electron Microscopy (EM) images of cancer cells, which are vital for understanding cancer progression and therapy resistance. The research focuses on three primary domains: (1) Image Quality Assessment and Denoising, where automated metrics and deep learning models validate faster, safer EM sample preparation protocols without compromising image quality; (2) Semi-supervised Semantic Segmentation, leveraging limited manual annotations to train models for accurate 3D segmentation of nuclei and nucleoli, essential for cancer diagnostics; and (3) Object Detection and Unsupervised Segmentation, integrating advanced detection and segmentation methods to analyze complex organelles such as mitochondria and endosomes at nanoscale resolution. The findings demonstrate the efficacy of these approaches in reducing annotation bottlenecks and enhancing the robustness of EM image analysis. By automating key aspects of image processing, this work contributes significantly to accelerating cancer research and supporting clinical applications

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    Culture of safety and non-physical harm from disrespect in an Oregon multi-hospital health system

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    Patients and families may suffer from non-physical harm during interactions with the health care system, leading to emotional, psychological, socio-behavioral, and financial impacts. This dissertation explored how a multi-hospital health system recognized and addressed non-physical harm within the context of organizational culture. In this mixed-methods study, an improvement-oriented framework was applied to patient/family-generated complaints and grievances; regression analyses assessed associations and variations between patient experiences of respect and staff perceptions of safety culture; and interviews with nurses, physicians, and executives were conducted to explore if and how the organization recognized non-physical harm as a priority. Recommendations across different key groups were presented

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