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Techniques and technology for dielectrophoresis separation and sensing of complex biological samples
No full textBiological nanoparticles present in bodily fluids carry diagnostically relevant biomarkers with potential for non-invasive disease detection through liquid biopsy. However, the isolation of these particles is challenging due to their small size and similar density to plasma. Conventional methods, such as ultracentrifugation, are time-consuming and require specialized equipment. Dielectrophoresis (DEP) has emerged as an effective particle isolation method. DEP utilizes compact and cost-effective electronics suitable for point-of-care and field applications. This work presents advances in DEP-based nanoparticle isolation, focusing on variability reduction, identification of novel targets, and integration with sensing technologies
The role of emotion regulation during the perinatal period on stress and parenting
No full textThis dissertation explores the role of emotion regulation in shaping stress and parenting experiences during the perinatal period, focusing on both risk and resilience factors. Two empirical studies were conducted to examine (1) the mediating role of emotion regulation in the association between adverse childhood experiences (ACEs) and parenting stress and (2) the efficacy of a mindfulness-based intervention in reducing psychological stress, depressive symptoms, and improving emotion regulation during pregnancy and postpartum
Single-unit representations of natural sound mixtures in auditory cortex
No full textThe world is full of sound—often in the form of noisy, acoustically cluttered environments—that we must make sense of. Noise vying for our attention overlaps with the sounds we care about and can be quite complex, requiring our brains to disentangle these different sound sources to allow noise-robust perception, an ability called auditory streaming. This means that somewhere between sounds hitting our eardrums and perceptual awareness our brains filter out the noise. The work presented in this dissertation looks at where and how individual neurons in the brain perform the computations that ultimately permit auditory streaming
