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Excitatory and inhibitory local circuitry of the insular cortex
No full textThe insular cortex mediates diverse functions, including taste, interoception, decision making, and emotion regulation. However, the cellular and microcircuit mechanisms underlying these functions remain largely unknown. This dissertation investigates local circuitry of the insular cortex and its associations with neuronal types, cytoarchitecture, and animal behavior
Evaluating quantitative microbiome profiling (QMP) approaches with a mock microbial dilution series
No full textWe developed a workflow for quantitative microbiome profiling to quantify bacterial abundance using a known mock microbial dilution series
Systems biology approaches for identifying molecular mechanisms of epithelial cell phenotype
No full textThis dissertation provides a deep exploration of how mammary epithelial cells respond to microenvironmental signals. Through a progression of increasingly complex models and integrative experimental approaches, we identified key regulatory networks and molecular mechanisms that link extracellular cues to cellular behavior. From cataloging transcriptional, proteomic, and phenotypic responses to uncovering the role of HIF1A in OSM-induced CCM and elucidating the synergistic effects of ligand combinations, this work advances our understanding of cellular signal integration
Brain immune signaling in response to binge-like drinking
No full textBinge drinking is associated with the genetic risk of developing alcohol use disorder (AUD) and is considered a strong predictor of AUD diagnosis. Excessive alcohol drinking produces lasting disruptions in inflammatory signaling in the brain and body. Chronic alcohol consumption leads to increased pro-inflammatory proteins which, over time, led to tissue damage. Chronic alcohol is associated with an increased risk of cancer and inflammation often is associated with cancer development and progression. The purpose of this thesis was to test the effects of apremilast administration on early-stage (four days) and initial (one day) binge-like drinking and nucleus accumbens (NAc) cytokine levels in iHDID-1 mice
Interview with Carol Craig, Ph.D., FNP
No full textDr. Carol Craig reflects on her journey into nursing, beginning with a degree in anthropology and evolving through decades of service in rural and community health. From early experiences in Alaska’s remote villages to founding a free clinic in Flagstaff, Arizona, Craig shares what shaped her career. She discusses her academic path, including earning two master’s degrees and a doctorate in ethnography, and her role in launching Family Nurse Practitioner (FNP) programs. Craig also recounts her leadership in developing the Oregon Consortium for Nursing Education (OCNE), which expanded access to baccalaureate nursing education across rural Oregon. Her story highlights the impact of community-based and non-hospital nursing and the importance of preparing nurses to support the needs of underserved populations
Remodeling neurons engage compartment-specific death and pruning mechanisms
No full textThis dissertation characterizes the developmental remodeling of a subset of neurons in the Drosophila nervous system. We highlight how these neurons undergo remodeling of specific cellular compartments and identify novel phagocytic molecules in astrocytes. This dissertation ultimately aims to address the complex neuron-glia interactions that occur during developmental remodeling of the nervous system
Promotion of DNA repair enzyme 8-oxoguanine glycosylase activity and its effect on Tauopathy models
No full textThis thesis explores the role of DNA repair enzyme 8-oxoguanine glycosylase (OGG1) in a Drosophila model through both genetic manipulation and the administration of small molecule agonists. Age- and neurodegeneration-related locomotor decline are significantly affected by Ogg1 RNAi knockdown and Ogg1 overexpression, while OGG1 agonists partially rescue deficits in an age-, sex-, and genotype-dependent manner. These findings support OGG1 as a potential therapeutic target, particularly in patients with genetic vulnerabilities to neurodegenerative disease