OHSU Digital Collections (Oregon Health and Science University)
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Impact of attachment design on the efficacy of custom clear aligners
No full textThis pilot split-mouth study evaluated whether rectangular beveled versus non-beveled composite attachments improve the predictability of rotational tooth movement with clear aligners. Maxillary anterior teeth were scanned before and after a controlled observation period, and rotation was quantified using a standardized digital coordinate system. Beveled attachments showed a trend toward greater rotational expression and efficiency, but the small sample size prevented formal statistical testing. The study established a reproducible measurement protocol and generated power estimates to guide a future, adequately powered randomized trial
Engineering biomimetic microenvironments for enhanced osteogenesis & regeneration of craniofacial bone defects
No full textThis dissertation demonstrates that engineered collagen-based microenvironments can be designed to improve craniofacial bone regeneration by integrating matrix mechanics, biomimetic mineralization, and self-assembled vasculature. Increased matrix density alone is sufficient to rapidly activate osteogenic mechanotransduction pathways, but this early advantage does not translate to improved long term bone regeneration, highlighting the need to balance mechanical reinforcement with biological accessibility. Incorporating nanoscale mineralization enhances early mechanosensing and significantly accelerates bone repair in vivo, with mineralization influencing both the extent and spatial pattern of regeneration as well as showing sex-specific healing responses. Finally, pre-vascularized, decellularized mineralized scaffolds support robust bone regeneration comparable to autologous grafts, demonstrating the potential for scalable, off-the-shelf graft alternatives
