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Les stations de vacances des années 1960-70 : comment leur architecture moderniste incarne-t-elle la France des Trente Glorieuses ?
No full textUne Musique simple et noble, un pays unifié et désunifié : la pensée des Lumières dans la musique régionale et l’unification nationale pendant la Troisième République en France
No full textPlus que des simples modificateurs : \u3cem\u3eL’expérience queer des personnes noires LGBTQIA+ en France à travers les nouveaux médias\u3c/em\u3e
No full textIntégration, identité et technologies numériques : une étude de cas des immigrés marocains de deuxième génération et la question d’identité culturelle dans l’espace numérique
No full textNaviguer l\u27altérité et l\u27appartenance au milieu de la modernisation : les Pygmées du Cameroun à travers le cinéma
No full textNeurons Underlying Aggression-Like Actions That Are Shared By Both Males And Females In \u3cem\u3eDrosophila\u3c/em\u3e
No full textAggression involves both sexually monomorphic and dimorphic actions. How the brain implements these two types of actions is poorly understood. We found that in Drosophila melanogaster, a set of neurons, which we call CL062, previously shown to mediate male aggression also mediate female aggression. These neurons elicit aggression acutely and without the presence of a target. Although the same set of actions is elicited in males and females, the overall behavior is sexually dimorphic. The CL062 neurons do not express fruitless, a gene required for sexual dimorphism in flies, and expressed by most other neurons important for controlling fly aggression. Connectomic analysis in a female electron microscopy dataset suggests that these neurons have limited connections with fruitless expressing neurons that have been shown to be important for aggression and signal to different descending neurons. Thus, CL062 is part of a monomorphic circuit for aggression that functions parallel to the known dimorphic circuits
Syllabus: Indigenous Art
No full textIndigenous arts of North America are expressions of deep cultural traditions as diverse as the lands with which they are inextricably linked. Here are five key texts that survey the subject
Concentration Dependence Of Aggregation Pathways During Aβ42 Aggregation Revealed By Single Molecule FRET Imaging And Deep Learning
No full textProtein aggregation into amyloid fibrils is the hallmark of several devasting neurodegenerative diseases. Understanding disease etiology hinges on our ability to uncover the molecular mechanics of how soluble monomers assemble to form insoluble fibrils consisting of thousands of constituent monomers. Although amyloid fibril formation is a highly specific self-assembly process, growth patterns and resultant fibril morphologies are highly dependent on solution conditions. Bulk biophysical methods are unable to fully characterize these mixtures of fibril polymorphs. Here, we develop and implement Förster resonance energy transfer (FRET) imaging to monitor the entire aggregation pathway of the Alzheimer’s Disease related peptide amyloid-β 42 (Aβ42) at the single fibril level in real-time. We incubated a mixture of donor-labeled, acceptor-labeled, and unlabeled Aβ42 monomers, which resulted in the formation of fibrils with diverse FRET efficiency values, indicating structural heterogeneity. FRET images reveal that increasing monomer concentration promotes the formation of a predominant fibril assembly, while fibrils formed at lower concentrations assemble via highly heterogeneous pathways. Deep learning methods enable segmentation of single fibrils within images of highly overlapping fibrils, allowing for quantitative analysis of the aggregation process. Fibrils corresponding to two major FRET efficiencies emerge from the single-fibril image data. Photon recoloring simulations support the assignment of these observed FRET populations as fibrils with parallel and anti-parallel structures
Sound Symbolism of Vowel Metaphors in Choral Pedagogy
No full textSingers face the daunting task of learning how to precisely control parts of their body that they cannot see. As a result, vocal pedagogy relies heavily on metaphorical language. This thesis will investigate 10 such adjectives used to describe, teach, and elicit vowel sounds in choral singing: “bright”, “dark”, “wide”, “narrow”, “open”, “closed”, “warm”, “harsh”, “rich”, and “thin.” This thesis seeks to discover if these vowel metaphors have specific acoustic and thus corresponding articulatory correlates in a sound symbolic capacity. A survey was conducted to assess judgments of sung vowels with respect to each vowel metaphor. Judgments were analyzed with respect to F1, F2, F3, and musician identity. Significant acoustic correlates were found for all 10 adjectives. The results of this study have important implications for vocal pedagogy, the perception of singing, and sound symbolism at large
