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Effect of Hesperidin on Lipid Profile, Inflammation and Apoptosis in Experimental Diabetes
No full textAbstract: In recent years, therapeutic approaches against diabetes-induced liver damage have attracted great interest. Studies indicate the anticarcinogenic, anti-inflammatory, antioxidant, and lipid-lowering potential of hesperidin (HESP), a flavonoid in citrus fruits. This study examined how HESP prevented streptozotocin (STZ)-induced diabetic liver damage. Four groups of seven rats each were created: Control, HESP (100 mg/kg/day), STZ (45 mg/kg), and STZ + HESP (45 mg/kg and 100 mg/kg/day, respectively). Serum AST, ALT, LDH, LDL, triglyceride, total cholesterol levels, and the TNF-α, IL-1β, and caspase-3 expression levels of liver tissue in the STZ group were higher than the other groups (p < 0.05). However, these values were significantly lower (p < 0.05) in the STZ + HESP group compared to the STZ group. Furthermore, administering HESP together with STZ reduced liver expression levels of caspase-3, TNF-α, and IL-1β, as well as blood levels of AST, ALT, LDH, LDL, triglyceride, and total cholesterol. HESP against diabetes-induced hepatic damage reduced proinflammatory cytokine levels, and returned the lipid profile, and apoptotic indicators to normal levels. These findings suggested that HESP therapy may be an important therapeutic role against diabetes-induced liver damage
News, Politics And International Relations: The French Press’s Perspective On The Turkey-Syria Crisis
No full textKIZILÇAM ÖZ VE DİRİ ODUNLARINA ARAP ZAMKI UYGULAMASI: RENK PARAMETRELERİNİN KARŞILAŞTIRMALI ANALİZİ
No full textA coupled nonlinear system of integro-differential equations using modified abc operator
No full textThis paper explores the necessary conditions required for the solutions of an integro-differential system of n-fractional differential equations (n-FDEs) in the modified-ABC case of derivative with initial conditions. The presumed problem is a linearly perturbed system. Some classical fixed point theorems are utilized to derive the solution existence criteria. Additionally, a numerical methodology utilizing Lagrange's interpolation polynomial is developed and implemented in a dynamical framework of a power system for practical applications. In addition, we investigate the properties of Hyers-Ulam's stability and uniqueness. The findings are evaluated using graphical methods to assess the precision and suitability of the approaches
Dietary inclusion of curry plant (Helichrysum italicum) extract in rainbow trout (Oncorhynchus mykiss) culture: Growth performance and gene expression related to digestion, antioxidant, and immune responses
No full textIn this study, a 60-day trial was conducted to determine the effects of curry plant (Helichrysum italicum) extract in the diet of rainbow trout (Oncorhynchus mykiss) with an initial average live weight of 15.84 ± 0.05 g on growth performance and gene expressions associated with digestion, antioxidant capacity, and immune response. Four experimental diets were formulated as a basal diet (Control; C) and diets supplemented with varying levels of curry plant extract (CP05; 0.5 g kg−1, CP1; 1 g kg−1, and CP2; 2 g kg−1). Growth indices showed significant increases in all curry plant extract groups compared to the C group (p < 0.05). Similarly, higher levels of trypsin, lipase, and amylase expressions were observed in the curry plant extract groups compared to the C group (p < 0.05). The superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) gene expression levels were elevated in the CP extract groups (p < 0.05). The expression levels of interleukin-1β (IL-1β), tumor necrosis factor (TNF-α), and interleukin-8 (IL-8) were also influenced by the incorporation of CP extract into the diet, showing significant changes (p < 0.05). In conclusion, this study experimentally demonstrates that supplementing the diet of rainbow trout with CP extract can positively influence healthy growth parameters
Perceptions of child abuse and neglect among nurses: an investigation in family health centers
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The Effect of Victory and Defeat on the Correlations of Stress Parameters Between the Horse and Rider in Kök-Börü Equestrian Teams
No full textThe presented study outlines a research plan aimed at determining the effects of winning and losing situations on the relationship levels between the rider and horse's stress, metabolic, and physiological parameters in Kök-Börü, a traditional equestrian team game. For this purpose, blood samples were collected from both the horses and riders of four different teams participating in two different Kök-Börü games before and after the games. Cortisol, ACTH, beta-endorphin, epinephrine, norepinephrine, T3 and T4 analyses were performed on the collected blood samples using species-specific commercial ELISA kits. Additionally, biochemical and haematological parameters in the same blood samples were tested using an autoanalyser. Based on the obtained data, it was found that there were both positive and negative correlations between most biochemical and haematological parameters of the winning teams' horses and riders before and after the game. However, when examining the correlations between the hormonal parameters of the winning teams' horses and riders before the game, only a negative correlation was found between ACTH and T4 (-0.529, p < 0.05), and no positive correlation was identified among any hormonal parameters. In conclusion, it was interpreted that in the equestrian team sport of Kök-Börü, there are significant changes in the hormonal parameters, especially before and after the game, between the horses and riders of the losing teams. Furthermore, it was concluded that winning and losing situations in Kök-Börü games did not have a significant impact on the correlations between haematological and biochemical parameters before and after the game for both the horses and riders