Institute for Advanced Science, Social, and Sustainable Future
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The role of policies in supporting biodegradable medical innovations for sustainable healthcare systems: A research review
No full textBackground: The global health crisis is a complex issue that requires coordinated efforts among individuals, organizations, and institutions. In this context, health policies play a crucial role in improving quality of life and population well-being. With the growing development of medical innovations based on biodegradable materials particularly in the advancement of medical devices and technologies strong policy support is essential. Such policies are expected to promote the adoption of sustainable innovations through the use of biodegradable materials, which not only have the potential to enhance healthcare effectiveness but also to support the long-term sustainability of health systems in the future. Methods: This study employs a literature review method to examine the role of policy in supporting medical innovation based on biodegradable materials for healthcare system sustainability. Secondary data were obtained from peer-reviewed journal articles published between 2020 and 2025 and indexed in Google Scholar. Findings: This study demonstrates that public policy plays a strategic role in accelerating medical innovation based on biodegradable materials to achieve a sustainable healthcare system. Through research support, regulation, and funding in various countries such as the European Union, the United States, China, and Japan, the development of eco-friendly biomaterials such as PLA, PCL, and magnesium composites has been promoted to reduce environmental impacts while enhancing the efficiency and resilience of the healthcare sector. Conclusion: The synergy between public policy and biomedical innovation using biodegradable materials is essential for creating a sustainable and resilient healthcare system. Government support and sustainability-oriented policies foster energy efficiency, renewable energy adoption, and effective waste management worldwide. Novelty/Originality of this article: This study emphasizes that integrating public policy with biodegradable-based medical innovation is vital for building a sustainable healthcare system. By combining policy, biomedical engineering, and environmental perspectives, it offers a more comprehensive approach than previous studies. The findings show that strong policy–innovation synergy can lay the groundwork for future sustainable healthcare development
Environmental determinants of leprosy: A spatial analysis
No full textBackground: Leprosy, or Morbus Hansen, remains one of the neglected tropical diseases (NTDs) that continues to pose major public health challenges in Indonesia. This study aims to analyze the spatial relationship between handwashing behavior with soap, access to healthy housing, and indoor air quality with leprosy incidence in East Java Province in 2022. Methods: An ecological study design was employed using secondary data obtained from the East Java Provincial Health Office. Spatial analysis was conducted using Moran’s I and Local Indicators of Spatial Association (LISA) through the GeoDa software to identify both global and local spatial autocorrelation patterns. Findings: The results revealed a negative spatial autocorrelation between household handwashing behavior and access to healthy housing with leprosy incidence (p < 0.05). This indicates that areas with lower handwashing practices and limited access to healthy housing tend to have higher leprosy case clusters. Meanwhile, indoor air quality showed no significant spatial association (p > 0.05). High-risk clusters were identified in Bangkalan, Pamekasan, and Sampang, while low-risk clusters were found in Magetan, Ponorogo, and Tulungagung. Conclusion: These findings highlight the need to integrate behavioral and environmental factors into leprosy prevention strategies, particularly through geographically targeted hygiene promotion and housing improvement programs in high-risk districts. Strengthening sanitation infrastructure and aligning leprosy control efforts with local development policies may help reduce spatial disparities in transmission. Future research should employ longitudinal data and incorporate broader social and biological determinants to better understand leprosy dynamics and inform more precise, evidence-based interventions. Novelty/Originality of this article: This study introduces a spatial-environmental framework that links household hygiene behavior, healthy housing access, and indoor air quality to leprosy distribution. This research approach offers new insights into environmental pathways of leprosy transmission and supports geographically targeted public health interventions
Correlation between family knowledge and preventive behaviors against pulmonary Tuberculosis transmission at regional hospital
No full textBackground: West Kalimantan Province ranks 15th in tuberculosis case notification rates and has the highest rate among the 34 provinces in Indonesia. One of the contributing factors to the incidence of tuberculosis is the poor behavior and attitudes of families. Therefore, family knowledge regarding the prevention of pulmonary tuberculosis transmission is important to be studied further. Methods: This study employed a quantitative research method using a cross-sectional approach. Data were collected through questionnaires. The sample consisted of the entire population included in the study, totaling 22 respondents. Data were analyzed using univariate and bivariate analysis techniques. Findings: The study showed that most respondents had good knowledge about pulmonary tuberculosis. Furthermore, respondents demonstrated good preventive behaviors against tuberculosis transmission, which were influenced by their adequate knowledge. Conclusion: This study concludes that there is a significant relationship between family knowledge and preventive behaviors toward pulmonary tuberculosis transmission in the Infectious Disease Ward of Regional General Hospital. Novelty/Originality of this article: This research focuses on the family context in disease prevention and health promotion. In addition, the study uses the most recent data relevant to current public health needs, providing updated evidence that supports the continuity of tuberculosis prevention research
Bridging agronomy and pharmacology the antidiabetic promise of Oldenlandia
Full text linkBackground: The growing global burden of diabetes and the limitations of current treatments require sustainable alternatives. This study aims to evaluate the potential of the weedy genus Oldenlandia as a novel, sustainable resource for diabetes management by synthesizing evidence from agronomy, phytochemistry, and pharmacology. Methods: A systematic literature review was conducted using major scientific databases. A multidisciplinary search strategy was employed, and the collected data were integrated using narrative synthesis. Findings: The analysis shows that Oldenlandia species are resilient plants requiring low agricultural inputs. They are rich in bioactive compounds like iridoids and flavonoids, and preclinical studies confirm significant antidiabetic effects, including lowered blood glucose and reduced inflammation via mechanisms such as AMPK-NF-κB pathway modulation. Conclusion: Oldenlandia presents a promising and sustainable candidate for developing new antidiabetic therapies, bridging traditional use with scientific validation. Novelty/Originality: This review offers a novel, integrated perspective that simultaneously evaluates the agronomic feasibility and pharmacological potential of a weed for diabetes treatment, a unique approach not commonly found in existing literature
Assessing behavioral determinants of sharia gold investment intention: The roles of literacy, motivation, inclusivity, and risk perception
No full textBackground: Indonesia has the second-largest Muslim population in the world, which provides a strong potential for the development of its sharia economy. However, in 2024, levels of sharia financial literacy and inclusivity remain low, with inclusivity lagging behind literacy. At the same time, sharia gold investment among young people is experiencing significant growth. This study aims to examine the influence of Islamic economic literacy, motivation, financial inclusivity, and risk perception on students’ interest in sharia gold investment at Universitas Gadjah Mada. Methods: This research applies a quantitative survey approach using a structured questionnaire with a five-point Likert scale. A total of 174 students were selected using purposive sampling. The data were analyzed using ordered logit regression with robust standard errors to determine which factors significantly affect students’ investment interest. Findings: The results show that Islamic economic literacy, motivation, financial inclusivity, and risk perception collectively influence students’ interest in sharia gold investment. However, only Islamic economic literacy and motivation have statistically significant positive effects, while financial inclusivity and risk perception do not show significant influence in the regression model. Conclusion: Improving Islamic economic literacy and strengthening students’ motivation are the most effective strategies to increase interest in sharia gold investment among young people. Novelty/Originality of this article: This study offers a comprehensive explanation of early-stage investment behavior by combining empirical survey data with inferential analysis, providing insights into the factors driving sharia investment interest in Indonesia’s developing Islamic finance market
Adaptation of Biscay model in Indonesian tax reform: SDGs-based fiscal incentive innovation to realize sustainable economic transformation towards golden Indonesia 2045
Full text linkBackground: The vision of a Golden Indonesia 2045 is a great goal of Indonesia in celebrating its 100 years of independence, but a number of challenges such as demographic bonus, climate change, and economic problems can be obstacles to its achievement. Facing these challenges, the government can implement Sustainable Development Goals (SDGs), in which case, the Biscay Model is one of the evolutions in the field of taxation that can help the development of SDGs implementation in Indonesia. Spain's macroeconomic indicators show positive prospects, characterized by GNI per capita growth increasing from 1.2% in 2019 to 2.7% in 2023, as well as FDI net inflows rising from USD 10.47 billion in 2019 to 19.92 billion in 2024. Methods: This research uses a qualitative method with a literature study approach to examine the opportunity to apply the Biscay Model in the Indonesian tax system as an instrument that supports the achievement of sustainable development goals. Findings: The results show that the Biscay Model has the potential to be applied in Indonesia because it can open up space for the private sector to play an active role in financing development, strengthen government and business collaboration, and accelerate the achievement of the Golden Indonesia Vision 2045. Conclusion: Thus, this model not only presents an innovative alternative fiscal strategy, but also an important opportunity to promote economic, social and environmental sustainability. Novelty/Originality of this article: The novelty of this research lies in assessing the direct connection between the SDGs-based taxation model and Indonesia's long-term development vision, thus offering a new perspective on the role of taxation in supporting sustainable transformation
Between mokṣa and nirvāṇa: Archaeological traces of Siwa–Buddha harmony in Bali and their eschatological worldview
No full textBackground: This article examines the eschatological worldview underlying the archaeological heritage of Siwa–Buddha traditions in Bali, focusing on how concepts of life, death, and post-mortem liberation were articulated through religious material culture. Drawing on archaeological evidence such as temple layouts, ritual iconography, and mortuary-related symbols, the study argues that Balinese Siwa–Buddha syncretism represents not merely a historical coexistence of religious traditions, but a coherent theological negotiation between two soteriological paradigms: mokṣa and nirvāṇa. Methods: This study employs a qualitative interpretative approach with an archaeological-critical and historiographical framework to examine Shiva–Buddha relations in Bali as a process of religious-cultural transformation shaping eschatological understandings of life, death, and liberation. Data were collected through archaeological observation, textual and inscriptional analysis, and theoretical literature review, and analyzed using thematic, semiotic, and historiographical deconstruction to interpret artifacts, sacred spaces, and rituals as material expressions of eschatological meaning. Findings: The findings suggest that Siwa–Buddha harmony in Bali produced an eschatological framework in which life and death were understood as a continuous process of spiritual refinement rather than as oppositional states. Architectural orientations, ritual spaces, and symbolic representations indicate a shared concern with purification, release from cyclical existence, and ultimate union with a transcendent reality. Conclusion: This synthesis challenges rigid sectarian classifications and reveals a localized eschatology that accommodated multiple paths to liberation within a single religious landscape. Novelty/Originality of this article: This study demonstrates that Southeast Asian religious heritage, particularly in Bali, offers an important case for understanding how plural religious traditions can converge in shaping shared conceptions of death, afterlife, and ultimate salvation
Effectiveness of the 6-month BPaLM regimen in a patient with rifampicin-monoresistant tuberculosis
Full text linkBackground: Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis and remains a global health problem, including in Indonesia. Rifampicin-resistant tuberculosis (TB) (RR-TB) is a form of anti-tuberculosis drug resistance in which Mycobacterium tuberculosis only shows resistance to rifampicin, without resistance to isoniazid or other first-line drugs. The combination of Drug Resistant Tuberculosis (TB RO) treatment regimens greatly influences the effectiveness of TB RO patient treatment management. The purpose of this study was to see the effectiveness of the 6-month BPaLM regimen in a patient with rifampicin-monoresistant tuberculosis in Sabu Raijua Regional Hospital, Sabu Raijua Regency, East Nusa Tenggara. Methods: This type of research is a quantitative study with a cross-sectional approach to see the effectiveness of the 6-month BPaLM regimen in a patient with rifampicin-monoresistant tuberculosis at Sabu Raijua Regional Hospital in 1 case treated from the beginning of treatment (baseline), monthly follow-up and until the end of treatment. Findings: The study results show that the BPaLM regimen is highly effective in eradicating RR-TB in patients in areas with limited facilities, such as the 3T (terpencil, terluar, dan tertinggal/ disadvantaged, frontier, and outermost) areas. Multidisciplinary clinical, laboratory, and radiological monitoring are key to successful therapy, including early detection of side effects and ensuring adherence. Therefore, this 6-month BPaLM regimen is highly effective in assisting in the management of RR-TB treatment. Conclusion: In conclusion, the 6-month BPaLM regimen demonstrates high effectiveness in treating rifampicin-monoresistant tuberculosis (RR-TB), even in limited-resource settings such as disadvantaged, frontier, and outermost areas. Comprehensive multidisciplinary monitoring is essential to ensure treatment success and patient adherence. Novelty/Originality of this article: This study provides new evidence of the successful implementation of the 6-month BPaLM regimen for rifampicin-monoresistant tuberculosis (RR-TB) in a remote, limited-resource setting (disadvantaged, frontier, and outermost area), demonstrating its practicality and effectiveness beyond controlled or urban healthcare environments
Diagnostic accuracy of loop-mediated isothermal amplification (LAMP) assays for dengue virus detection in serum: A systematic review and meta-analysis
Full text linkBackground: Rapid and accurate diagnosis of dengue virus (DENV) infection remains a challenge in endemic areas. Current gold standard methods have several limitations and are often unsuitable for resource-limited settings. Loop-mediated isothermal amplification (LAMP) offers a rapid, cost-effective, and field-adaptable alternative. This meta-analysis aimed to evaluate the diagnostic accuracy of LAMP for detecting DENV infection in human serum samples. Methods: A comprehensive literature search was conducted in PubMed, Scopus, Taylor & Francis, and Wiley databases up to July 2025. Pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) were calculated to assess the diagnostic performance of LAMP. Meta-DiSC 1.4 was used for analysis, and methodological quality was evaluated using the QUADAS-2 tool. Meta-regression was performed to explore potential sources of heterogeneity. Findings: Five studies involving 807 samples were included in this meta-analysis. The pooled meta-analysis results were as follows: sensitivity 0.83 (95% CI: 0.80–0.85), specificity 0.95 (95% CI: 0.91–0.98), PLR 14.31 (95% CI: 7.82–26.20), NLR 0.15 (95% CI: 0.07–0.31), and DOR 103.30 (95% CI: 23.13–461.42). The summary of AUC was 0.9633, indicating good diagnostic accuracy. Meta-regression showed no significant effect of study design, sample size, geographic region, cross-reactivity testing, or reference standard on diagnostic accuracy. Conclusion: LAMP provides a highly accurate and reliable method for DENV detection in human serum, suitable for both clinical and field use. Its routine implementation may improve dengue outbreak management and surveillance in endemic areas. Novelty/Originality of this article: This is the first meta-analysis to comprehensively evaluate the diagnostic accuracy of LAMP for DENV detection in human serum. By synthesizing evidence from multiple studies, it provides stronger statistical power than individual reports and highlights the robustness of LAMP across diverse settings
The collaborative research and education system on poultry and eggs (CRESCOVA) to achieve balanced nutrition and prevent stunting
No full textBackground: Stunting remains one of Indonesia’s most critical public-health challenges, affecting child growth, cognitive development, and long-term human-capital productivity. Despite national efforts to accelerate stunting reduction, gaps persist in dietary diversity, nutrition literacy, and integration between health and agricultural sectors. Poultry and eggs—nutrient-dense, affordable, and widely acceptable—represent a strategic yet underutilized entry point for improving child nutrition. This study aims to synthesize interdisciplinary evidence and develop the CRESCOVA (Collaborative Research and Education System on Poultry and Eggs) framework as an innovative model that integrates nutrition education, small-scale poultry practices, and community empowerment to support Indonesia’s stunting-reduction agenda. Method: This research employed a qualitative descriptive literature-review design. A systematic search was conducted across Scopus, PubMed, Web of Science, ScienceDirect, DOAJ, Google Scholar, FAO, WHO, UNICEF, World Bank, Kemenkes, and BKKBN repositories (2019–2025), supplemented with foundational meta-analyses. A total of 52 eligible sources were analyzed using narrative thematic synthesis, covering nutrition-sensitive agriculture, animal-source foods, community-based education, and cross-sector collaboration. Extracted themes were integrated to construct the CRESCOVA conceptual model and validated against national policies and global development frameworks. Finding: Results show consistent evidence that egg and poultry consumption significantly improves linear growth and dietary adequacy among children, while participatory nutrition education enhances caregiver behavior. Cross-sector interventions linking health, education, and agriculture demonstrate greater impact than fragmented programs. Based on these findings, the CRESCOVA model offers a scalable, context-appropriate framework that strengthens household capacity, promotes women’s empowerment, and aligns with SDG 2 and SDG 3 to improve food security and child nutrition outcomes. Conclusion: CRESCOVA provides a practical strategy to operationalize multisectoral stunting-reduction efforts through integrated education and poultry-based learning. Further field implementation and evaluation are recommended to assess feasibility across Indonesia’s diverse regions. Novelty/Originality of this article: This study introduces the CRESCOVA framework as a novel socio-technical intervention that specifically bridges the gap between nutrition-sensitive agriculture and public health education in the Indonesian context