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Strategic Directions for Big Data Analytics in E-Commerce with Machine Learning and Tactical Synopses: Propositions for Intelligence Based Strategic Information Modeling (SIM)
No full textE-commerce has seen tremendous growth in big data and the continued acceleration in growth of information facets. There has been a significant scaling up of information quantity, granularity, complexity, equivocality and variety. Data analytics tools and techniques (DATT) such as machine learning and artificial intelligence have been widely leveraged to gain competitive advantage and such resources are readily available. However, there has been a lack of clarity surrounding, what we term as 'strategic information modeling' (SIM). Our research presents propositions to provide contextual clarity to the rapidly expanding Big Data environment and also an articulation of the emerging informational challenges in e-commerce. Our analysis provides insights into the potential role of SIM and SIM generated competitive advantages and concludes with e-commerce relevant propositions for an optimal path towards SIM and machine learning.Version of Record (VoR
Systematic identification, characterization, and conservation of adjacent-gene coregulation in the budding yeast Saccharomyces cerevisiae
Get PDFIt is essential that cells orchestrate gene expression for the specific niche that they occupy, and this often requires coordination of the expression of large sets of genes. There are multiple regulatory systems that exist for modulation of gene expression, including the adjacent-gene coregulation of the rRNA and ribosome biogenesis and ribosomal protein families. Both gene families exhibit a nonrandom genomic distribution, often clustered directly adjacent to another member of the same family, which results in a tighter transcriptional coordination among adjacent paired genes than that of the unpaired genes within each regulon and can result in a shared promoter that coordinates expression of the pairs. This nonrandom genomic distribution has been seen in a few functionally related gene families, and many of these functional pairings are conserved across divergent fungal lineages. To date, the significance of these observations has not been extended in a systematic way to characterize how prevalent the role of adjacent-gene coregulation is in transcriptional regulation. In the present study, we systematically analyzed the transcriptional coherence of the functional pairs compared to the singletons within all gene families defined by the Gene Ontology Slim designation, using Saccharomyces cerevisiae as a model system, finding that clusters exhibit a tighter transcriptional correlation under specific contexts. We found that the longer a functional pairing is conserved the tighter its response to broad stress and nutritional responses, that roughly 25% of gene families exhibit a nonrandom genomic distribution, and that many of these clusters are conserved. This suggests that adjacent-gene coregulation is a widespread, yet underappreciated, transcriptional mechanism.Version of Record (VoR
Digitization on a dime
Get PDFThis presentation was given at the New Jersey Library Association (NJLA) conference in Atlantic City, New Jersey, on June 1, 2018.Digitization is often seen as an expensive prospect for institutions who want to share their archival and historic material online with the public, but this doesn't always have to be the case. This session will discuss low-budget strategies to handle digitization while ensuring quality. The session includes specific examples with tips and tricks on when to splurge and when to pinch your pennies
Ribosome Biogenesis: Streamlining the Genome for the Efficient Production of this Biological Nanomolecular Machine
Get PDFOne of the most complex nanomolecular machines found within the cell is the ribosome. Integral to translation, the ribosome is conserved on a functional level across all domains of life. The eukaryotic ribosome is comprised of approximately 80 Ribosomal Proteins (RPs) and four rRNAs that are highly processed, folded, and assembled by more than 200 processing and assembly factors (termed rRNA and ribosome biogenesis factors). The cell requires roughly stoichiometric levels of each of these components to meet cellular demand for protein synthesis, to maintain fidelity of this process, and to ensure that faithful translation occurs. Ribosome biogenesis is an energetically consumptive process, and there are many mechanisms the cell employs in order to properly balance expression of the requisite components. The failure to properly regulate this process results in cellular dysfunction, in higher eukaryotes it can lead to disease such as various cancers. This commentary will discuss recent developments in the understanding of the role that spatial positioning – the linear arrangement of genes along the chromosome throughout the genome – plays in the regulation of ribosome biogenesis, focusing on lessons learned from the budding yeast, Saccharomyces cerevisiae, and their implications in higher eukaryotic organisms
How are we doing?: Using faculty feedback to assess the impact of library instruction on student work
Get PDFData collected from surveys of faculty who brought their students for library instruction provide the basis for this article. Faculty can be reached through surveys developed using low cost or even no-cost tools, and results have been used to help establish a connection between library instruction and quality of student work. Details on the surveys and summary data results will be highlighted as will results from a survey of faculty who do not schedule instruction, thus providing easily replicable assessment tools that can be adapted for the needs of other academic libraries
