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Re-challenge of afatinib after 1st generation EGFR-TKI failure in patients with previously treated non-small cell lung cancer harboring EGFR mutation
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Factors impairing cell proliferation in the granulation tissue of pressure ulcers: impact of bacterial burden.
Get PDF埼玉医科大学博士（医学）平成30年度The authors aimed to assess the factors that impair cell proliferation in the granulation tissue of pressure ulcers using immunohistochemistry for the cell proliferation marker Ki‐67. This was a single center, cross‐sectional study. The study included 86 patients with stage III or IV pressure ulcers. Two granulation tissue biopsy specimens were obtained from 86 patients. The specimens were used for histological examination, Ki‐67 immunohistochemistry, and bacterial count assessment. The % of Ki‐67‐stained cells was considered as the Ki‐67 index. Pearson's product–moment correlation coefficient (r) was used to assess the relationship between the Ki‐67 index and other quantitative variables, including age, body mass index, bacterial count (Log10 CFU/g), serum albumin level, hemoglobin level, white blood cell count, and C‐reactive protein level. The Mann–Whitney U test was used to compare the mean Ki‐67 index according to gender, diabetes, smoking status, and wound culture. Univariate and multivariate linear regression analyses were used to assess the association between the Ki‐67 index and other parameters. The Mann–Whitney U test revealed that the bacteria‐positive group had a lower Ki‐67 index (p = 0.045). Bacterial count demonstrated a significant negative correlation with the Ki‐67 index (r = −0.325, p = 0.002). Multivariate linear regression analysis showed that bacterial count was a significant predictor of the Ki‐67 index. The adjusted β‐coefficient was −1.34 (95% confidence interval, −2.01 to −0.66, p < 0.001). Among the isolated bacteria, Corynebacterium spp. and Staphylococcus aureus were significantly associated with a low Ki‐67 index, but Pseudomonas aeruginosa was not. These results suggest a negative relationship between bacterial count and cell proliferation in pressure ulcer granulation tissue, as indicated by the Ki‐67 index. Granulation tissue formation in pressure ulcers may be accelerated if high bacterial load is treated appropriately
Optic disc vessel density in non-glaucomatous and glaucomatous eyes: an enhanced-depth imaging optical coherence tomography angiography study
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Simultaneous multi-slice MR imaging of the hip at 3T to reduce acquisition times and maintain image quality
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Clinicopathological correlation of ARID1A status with HDAC6 and its related factors in ovarian clear cell carcinoma
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Generation of ventilation/perfusion ratio map in surgical patients by dual-energy CT after xenon inhalation and intravenous contrast media
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