LOUIS University of Alabama in Huntsville
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Research Aircraft Optimization from generated Requirements For Use in AIAA DBF Competition
Get PDFhttps://louis.uah.edu/research-horizons/1355/thumbnail.jp
An Evaluation of Concepts Related to Affordability in Military Domains
Get PDFhttps://louis.uah.edu/research-horizons/1363/thumbnail.jp
Bias Against Severe Mental Illness on Treatment in Emergency Medical Situations
Get PDFhttps://louis.uah.edu/research-horizons/1364/thumbnail.jp
2024 M. Louis Salmon Library Annual Report
No full texthttps://louis.uah.edu/lib-annual-reports/1001/thumbnail.jp
Capture of patient-reported outcomes data to trigger a clinical decision support system feature in chronic obstructive pulmonary disease management
No full textDocumentation of patient symptoms directly related to chronic obstructive pulmonary disease (COPD) is primarily notated as free text within the electronic health record. This project aimed to automate the capture of patient-reported outcomes (PRO) data for improving the care of patients diagnosed with COPD. The COPD Assessment Test (CAT) questionnaire was electronically deployed in beta-testing to trigger a clinical decision support feature identified as a Best Practice Advisory (BPA). This project used a quality improvement design to enhance the clinical management of adult patients diagnosed with COPD in the ambulatory setting. The DNP student used a retrospective review of the electronic health record and survey responses to evaluate this project. BPAs were useful in displaying GOLD guideline recommendations and pertinent clinical information to participants; however, pulmonary rehabilitation referrals were comparable before and after implementation
Small molecule modulation of the p75 Neurotrophin Receptor attenuates neurodegeneration in an in vitro model of Parkinson’s disease
Get PDFThe p75 Neurotrophin Receptor (p75NTR) is a multifunctional transmembrane protein expressed in distinct regions of the adult nervous system. p75NTR regulates various functions, including neuronal survival or apoptosis interacting with coreceptors Trk receptors or sortilin. Activation of p75NTR occurs through proteolytic processing, and we previously demonstrated that oxidative stress induces activation of p75NTR in LUHMES cells, a neuronal cell line derived from the human ventral mesencephalon. Dopaminergic neurons of the ventral mesencephalon are vulnerable to oxidative stress and neurodegeneration associated with Parkinson’s disease (PD). Thus, we evaluated the mechanisms behind p75NTR activation and its physiological implications in a PD model. Our findings reveal that oxidative stress induces proteolytic processing of p75NTR in LUHMES cells, promoting internalization into endosomes. We also found that pharmacological modulation of p75NTR using LM11A-31 protects LUHMES cells from neurite degeneration and reduces apoptosis associated with oxidative stress, indicating p75NTR as a potential therapeutic target for PD
Functionalizing silicon oxide like surfaces with fatty acids
Get PDFThe goal of this project was to make flat hydrophilic, silicon oxide-like surfaces hydrophobic. Using fatty acids in a wet chemistry approach. Glass, mica, and silicon wafer surfaces were cleaned with standard methods from the literature. The substrates were functionalized with oleic acid and stearic acid in ethyl alcohol. The solution concentration was held constant at 100 times a theoretical minimum concentration. The substrates were immersed at various functionalization times and various solution temperatures. Contact angle goniometer was used to measure the contact angle for water on the functionalized surfaces. The results confirmed that glass and oxidized silicon wafer surfaces can be made hydrophobic with oleic or stearic acid. The optimal immersion time in oleic acid was 1,000 min. At longer times, the surfaces become hydrophilic again. Functionalizing with stearic acid gave comparable contact angles to oleic acid for room temperature and 80 °C. Contact angles for oleic acid were lower at intermediate temperatures. The observations were proposed to be due to a bilayer formation at higher acid concentration
