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Updated measurement of CP violation and polarisation in Bs0→J/ψK¯∗8920 decays
Get PDFA time-integrated angular analysis of the decay Bs0→J/ψK¯∗8920, with J/ψ → μ+μ− and K¯∗8920→K−π+, is presented. The analysis employs a sample of proton-proton collision data collected by the LHCb experiment during 2015–2018 at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 6 fb−1. A simultaneous maximum-likelihood fit is performed to the angular distributions in bins of the K−π+ mass. This fit yields measurements of the CP-averaged polarisation fractions and CP asymmetries for the P-wave component of the K−π+ system. The longitudinal and parallel polarisation fractions are determined to be f0 = 0.534 ± 0.012 ± 0.009 and f|| = 0.211 ± 0.014 ± 0.005, respectively, where the first uncertainty is statistical and the second is systematic. The CP asymmetries are measured with 3–7% precision and are found to be consistent with zero. These measurements, along with an updated determination of the branching fraction relative to the B0 → J/ψK*0 decay, are combined with previous LHCb results, providing the most precise values for these observables to date.info:eu-repo/semantics/publishedVersio
Learning trajectories: a tool for teaching and learning mathematics in early childhood education
Get PDFPromover una actividad matemática de calidad desde las edades iniciales es uno de los objetivos de la comunidad de investigación en educación matemática infantil y primaria. En este artículo se presenta el enfoque de las trayectorias de aprendizaje como una herramienta que puede ayudar a mejorar los procesos de enseñanza y aprendizaje de las matemáticas en dicha etapa. Se describen dos propuestas de trayectorias de aprendizaje. Una para la medida de longitud y otra para la simetría. Estas propuestas han sido implementadas con niños de 5-7 años. Se muestra que las experiencias escolares centradas en los niños y en sus formas de razonamiento resultan eficaces para desarrollar su pensamiento geométrico.info:eu-repo/semantics/publishedVersio
Novel zwitterionic densely charged neutral sulfobetaine polymeric micelles for oral delivery of therapeutic peptides: a proof-of-concept study
Get PDFDensely charged but neutral sulfobetaine polymeric micelles (PMs) were designed with the aim of efficiently permeating the intestinal mucus and releasing the intact peptide cargo close to the intestinal epithelial surface. Using RAFT chemistry, butyl methacrylate and dimethyl aminoethyl methacrylate copolymers were synthesised and then reacted with propane sultone to form amphiphilic block copolymers comprising hydrophilic zwitterionic sulfobetaine and lipophilic butyl methacrylate (BMA). Small (diameter <50 nm), spherical BMA–sulfobetaine PMs with a near neutral surface charge potential and loaded with a model peptide cargo, the GLP1-agonist peptide exenatide, were then formed by nanoprecipitation. In vitro peptide release studies from the PMs showed that less than 0.9% of the peptide load was released within the first 2 h (i.e. there was no ‘burst’ effect), with the release unaffected by highly acidic conditions. Thereafter, a sustained release was evident with 43% of the peptide load released in 24 h. In vitro screening (cytotoxicity assay) showed that the PMs did not cause loss of epithelial cell viability. Multiple particle tracking showed that the PMs were very highly permeant through the intestinal mucus. An in vivo non-clinical rodent pharmacokinetic study demonstrated the oral delivery of the exenatide-loaded PMs to achieve an extent of peptide bioavailability of 13% relative to subcutaneous (s.c.) exenatide solution injection. A pharmacodynamic study showed the efficacy of the oral exenatide-loaded PMs with significant reductions in blood glucose following a glucose challenge test. In conclusion, a novel family of sulfobetaine PMs have been demonstrated as stable carriers, efficiently permeating the intestinal mucus and with the potential for exploitation in the oral delivery of therapeutic peptides.info:eu-repo/semantics/publishedVersio
Mapping innovation tools and financial inclusion: a bibliometric analysis
Get PDFThis study employs bibliometric and visualisation techniques to analyse global trends in financial inclusion and the innovative tools that promote it. By examining a multi-database compilation of 4202 documents sourced from Scopus and Web of Science, the significant role of book chapters in disseminating research in this field is highlighted. Our analysis reveals rapid growth in publications, particularly from China and India, and identifies key influential works and authors. Additionally, it is observed that financial inclusion is approached from a multidisciplinary perspective. The findings of this study also indicate a shift in research focus from traditional concepts such as “housing” and “banking” to “digitalisation” and “sustainability.” Key research trends in financial innovative tools include regulatory frameworks, mobile money, and financial education. The issues discussed in this article seek to contribute to the ongoing dialogue on developing intellectual frameworks withing the financial inclusion literature. They offer valuable insights for policymakers, industry practitioners, and researchers in the fields of financial innovation and inclusion.info:eu-repo/semantics/publishedVersio
Automated tool for cylindrical glass container blow and blow mold design
Get PDFThe manufacture of perfumery bottles using the blow-and-blow technique necessitates iterative design and production of intermediate or preparation molds to achieve an appropriate thickness distribution. Designers seek a specific glass thickness at the bottle's bottom as an indicator of quality while ensuring a minimum thickness in the rest of the bottle, particularly the neck, to withstand vertical compressive loads during bottle filling. One cost-reduction strategy involves the use of finite element simulations; however, this technique demands significant engineering time and validation efforts. This study proposes a novel method for designing cylindrical bottles, facilitating the automated generation of preparation mold geometries for manufacturing. Key findings include the successful parameter-based analysis accounting for container capacity, mass, and height-to-diameter aspect ratio which was experimentally validated across several container sizes against traditional experimental iterations. Validation tests demonstrated that the automatically generated geometries yield functional bottle designs capable of withstanding compressive loads. The primary advantage of this approach lies in a substantial reduction in development time, from 32.9 to 18.3 days, providing a significant competitive edge. However, the current methodology is applicable to only 6% of the bottles in the production range. Expanding its applicability will require further database analysis to incorporate additional parameters for other bottle geometries. This limitation underscores the potential for continued refinement and broader industrial adoption.info:eu-repo/semantics/publishedVersio
Optimizing Reservoir Separability in Liquid State Machines for Spatio-Temporal Classification in Neuromorphic Hardware
Get PDFIn this paper, we propose an optimization approach using Particle Swarm Optimization (PSO) to enhance reservoir separability in Liquid State Machines (LSMs) for spatio-temporal classification in neuromorphic systems. By leveraging PSO, our method fine-tunes reservoir parameters, neuron dynamics, and connectivity patterns, maximizing separability while aligning with the resource constraints typical of neuromorphic hardware. This approach was validated in both software (NEST) and on neuromorphic hardware (SpiNNaker), demonstrating notable results in terms of accuracy and low energy consumption when using SpiNNaker. Specifically, our approach addresses two problems: Frequency Recognition (FR) with five classes and Pattern Recognition (PR) with four, eight, and twelve classes. For instance, in the Mono-objective approach running in NEST, accuracies ranged from 81.09% to 95.52% across the benchmarks under study. The Multi-objective approach outperformed the Mono-objective approach, delivering accuracies ranging from 90.23% to 98.77%, demonstrating its superior scalability for LSM implementations. On the SpiNNaker platform, the mono-objective approach achieved accuracies ranging from 86.20% to 97.70% across the same benchmarks, with the Multi-objective approach further improving accuracies, ranging from 94.42% to 99.52%. These results show that, in addition to slight accuracy improvements, hardware-based implementations offer superior energy efficiency with a lower execution time. For example, SpiNNaker operates at around 1–5 watts per chip, while traditional systems can require 50–100 watts for similar tasks, highlighting the significant energy savings of neuromorphic hardware. These results underscore the scalability and effectiveness of PSO-optimized LSMs on resource-limited neuromorphic platforms, showcasing both improved classification performance and the advantages of energy-efficient processing.info:eu-repo/semantics/publishedVersio
Estilo personal del terapeuta y Alianza terapéutica: particularidades en la atención terapéutica en población infantil con diagnóstico Trastorno del Espectro Autista
Get PDFTFM del Màster Universitari en Psicologia General Sanitària tutoritzat per Clara Mateu MartínezEl presente estudio explora la conexión entre el Estilo Personal del Terapeuta (EPT) y la Alianza
Terapéutica (AT) en intervenciones psicoterapéuticas dirigidas a niños con Trastorno del Espectro
Autista (TEA). A partir de un diseño cualitativo exploratorio, se realizaron entrevistas a seis
terapeutas especializados en psicoterapia infantojuvenil, lo que permitió identificar estrategias
específicas utilizadas en la práctica clínica. Los hallazgos resaltan la importancia de la flexibilidad, la
empatía y la capacidad de los terapeutas para adaptarse a las necesidades personales y evolutivas del
niño y a su contexto familiar y educativo. Asimismo, se concluye que la implicación activa de los
cuidadores y la colaboración con el entorno escolar son fundamentales para fortalecer la AT y
optimizar los resultados terapéuticos. Este trabajo contribuye al desarrollo de enfoques terapéuticos
más integrales y personalizados, abriendo nuevas líneas de investigación en psicología clínica
infantojuvenil.This study investigates the interplay between the Therapist’s Personal Style (TPS) and the
Therapeutic Alliance (TA) in psychotherapeutic interventions for children with Autism
Spectrum Disorder (ASD). Through an exploratory qualitative design, interviews were
conducted with six therapists specializing in child and adolescent psychotherapy, identifying
specific strategies employed in clinical practice. The findings underscore the importance of
flexibility, empathy, and the therapist's ability to adapt to the unique characteristics of the
child and their family and educational contexts. Additionally, the active involvement of
caregivers and collaboration with the educational environment were found to be crucial for
strengthening the TA and enhancing therapeutic outcomes. This research contributes to the
development of more comprehensive and tailored therapeutic approaches, paving the way for
further studies in child clinical psychology.info:eu-repo/semantics/publishedVersio
La darrera copa: Un procés de reconstrucció personal
Get PDFEn aquest Treball de Fi de Grau (TFG), s’exposa el cas real d’una persona amb addicció a
l’alcohol, a qui es fa referència amb el pseudònim de “Diego”. L’objectiu principal és
identificar i analitzar els diferents factors que poden incidir tant en l’inici com en el
manteniment del consum problemàtic. La seva història reflecteix que l’addicció és una
malaltia complexa que afecta múltiples àmbits de la vida de la persona i del seu entorn
- emocional, familiar, laboral, entre d’altres – i que implica molt més que abandonar el
consum. Tot i les dificultats del procés, la recuperació és possible i el vincle establert amb
els professionals de referència que l’acompanyen resulta clau per sostenir la motivació i la
continuïtat en el tractament.info:eu-repo/semantics/publishedVersio
Effects on prosociality and learning of university students from service-learning in a prison context
Get PDFIntroducción: la metodología Aprendizaje-Servicio (ApS) es un enlace entre el ámbito acadé-mico y el social con un doble objetivo, aprender contenidos al mismo tiempo que se presta un servicio a la sociedad.Objetivo: analizar la influencia que tiene sobre la conducta prosocial de estudiantes universita-rios su participación en un programa de Aprendizaje-Servicio en un centro penitenciario me-diante la educación física y evaluar el impacto del proyecto sobre la percepción de los aprendi-zajes de los alumnos.Metodología: el estudio combina una metodología cuantitativa (Prosocialness Scale for Adults y la Escala de Conducta Prosocial) y una cualitativa (cuaderno de seguimiento reflexivo y mesas de discusión) con una muestra de estudiantes universitarios compuesta por 55 hombres y 42 mujeres de entre 19 y 35 años (M=22,17 y DS= 4,38).Resultados: los resultados obtenidos presentanmejoras en la conducta prosocial sin que estas sean significativas. Complementariamente, los alumnos perciben una mejora de su aprendizaje de la competencia profesional y en la concienciación y comprensión del colectivo recluso. Conclusiones: se refuerzala utilidad del Aprendizaje-Servicio de carácter puntual en un centro penitenciario sobre los aprendizajes de los alumnos universitarios.Introduction: the Service-Learning (SL) methodology is a link between the academic and social spheres with a dual objective: learning content while providing a service to society.Objective: to analyze the influence on the prosocial behavior of university students participat-ing in a Service-Learning program in a prison through physical education,and to assess the impact of the project on students' perception of their learning. Methodology: the study combines a quantitative methodology (Prosocialness Scale for Adults (Caprara et al., 2005) and the Prosocial Behavior Scale (Auné & Attorresi, 2017)), and qualita-tive methodology (reflective follow-up notebook) with a sample of 55 men and 42 women be-tween 19 and 35 years old (M=22.17 and SD= 4.38) university students. Results: the results show improvements in prosocial behavior without these being significant. Additionally, the students demonstrate learning in the improvement of professional compe-tence and the awareness and understanding of the incarcerated collective. Conclusions: the usefulness of the punctual Service-Learning in a penitentiary center on the learning of university students is reinforced.info:eu-repo/semantics/publishedVersio
Residents’ values: Co-designing social housing retrofit
Get PDFResidents’ values in social housing retrofit extend beyond energy efficiency targets to encompass complex social and physical considerations, shaping their acceptance and experience of interventions. These values appear to influence retrofit success yet are often overlooked in policy and practice that prioritise technical performance. This paper investigates what residents value in social housing retrofit through a focus group method with the Sutton Estate in London, combining institutional stakeholder (housing association and architect) and resident perspectives. Content analysis of focus group questionnaires, discussions, and consensus-building activities revealed four key resident values: (1) good stakeholder relationships, emphasising trust-building through personal connections; (2) access to information, requiring clear, continuous communication through multiple channels; (3) comfort, health, and safety, integrating physical and mental wellbeing; and (4) building and community longevity, focusing on preserving building character and social sustainability. The findings suggest that social housing retrofit may benefit from a holistic approach integrating residents’ values throughout the project lifecycle, addressing the social, physical, and long-term sustainability of homes and communities. The findings highlight the importance for housing associations, architects, and policymakers to consider residents’ values when developing retrofit strategies, balancing technical requirements with residents’ needs and priorities.info:eu-repo/semantics/publishedVersio