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Learning to See Plants: Overcoming Future Teachers’ Plant Blindness Through Outdoor Educational Activities
No full textSynthesis, crystallography, biological activity, and molecular modeling studies of some 3-Aryl-2-(4-(substitutedphenyl)thiazol-2-yl) acrylonitrile derivatives
No full textIn this study, a series of 3-aryl-2-(4-(substitutedphenyl)thiazol-2-yl)acrylonitrile derivatives, was synthesized and their structures were elucidated using 1H/13CNMR , IR, HRMS and quantum crystallography methods. Ab initio quantum mechanics (QM) was applied to predict their molecular geometry and frontier molecular orbital parameters (FMO) in aqueous medium. Molecular descriptors were calculated to predict their druglikeness. Antimicrobial activities of the synthesized compounds were investigated against Mycobacterium tuberculosis H37Rv strain, various Gram-positive and Gram-negative bacteria, and three Candida spp. were evaluated in vitro using isoniazid, ethambutol, ciprofloxacin, and fluconazole (Diflucan) as reference drugs. Among the tested compounds, 2-(4-(2,4-dichlorophenyl)thiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)acrylonitrile (10) was found to be a promising antifungal agent with a minimum inhibitory concertation (MIC) value of 32 mu g/mL against C. parapsilosis. Molecular docking was performed to explain the molecular mechanism of its activity. Based on these findings, the title compounds serve a promising starting point for further structure-activity relationships and medicinal chemistry studies
Reframing incremental peritoneal dialysis: prioritizing minimum glucose exposure to preserve residual kidney function
No full textTurkish Adaptation of a Self-Report Measure for Current Achievement: The Current Motivation Questionnaire
No full textMedical student learning in the operating room: a qualitative study from the perspectives of students and the OR team
No full textSpatial location optimization of e-Hub in Dublin, Ireland: A GIS-based spherical fuzzy AHP with parsimonious preference information
No full textCities are under pressure to provide mobility options that reduce car dependence while improving connectivity. One promising strategy is the development of integrated electric mobility hubs (e-Hubs), yet their success depends heavily on where they are located. This study proposes a decision framework that links GIS analysis with a parsimonious spherical fuzzy AHP to identify the most suitable locations for e-hubs. The framework, designed to manage multiple spatial criteria and account for expert uncertainty while minimizing the complexity of pairwise comparisons, was applied to Dublin using 32 indicators grouped into eight themes. The results highlight central districts such as D01, D02, D04, D06, D07, and D08 as the most suitable areas, reflecting their dense population, multimodal transport links, and concentration of destinations. In contrast, outer districts scored lower due to weaker networks and more dispersed development. Beyond producing a suitability map, the study offers a transferable method that can guide policymakers in planning and prioritizing sustainable mobility investments
Borate and magnetic core containing layered gadolinium hydroxide hybrid materials: A potential agent for cancer diagnosis and treatment
No full textCancer is one of the most common diseases that causes death, and chemotherapy is one of the effective ways to treat cancer clinically. Conventional chemotherapy, however, struggles to distinguish between cancerous and normal cells, which can cause patients to suffer serious side effects. Additionally, their distribution in tumor tissue cannot be monitored in real-time because conventional chemotherapeutic drugs cannot be directly observed in the body. It is therefore imperative to develop novel materials to mitigate the aforementioned challenges in cancer therapy, enhance the efficacy of imaging agents for magnetic resonance imaging (MRI), and pioneer innovative techniques such as neutron capture therapy (NCT). Furthermore, a single material has the potential to be utilized in multiple treatment and diagnostic procedures, which could enhance the efficacy of these treatments. The production of these materials, which have the potential to be used for both diagnostic and therapeutic purposes, and their clinical application as soon as possible, are of great importance and require urgent attention. In this context, a new functional hybrid material was developed that has the potential to be used both simultaneously as a T1 & T2 (positive and negative contrast agents) agent in the diagnosis of cancer with MRI and simultaneously in Gadolinium-Boron Neutron Capture Therapy (GdBNCT), which is a combination of new cancer treatment methods such as Boron Neutron Capture Therapy (BNCT) and Gadolinium Neutron Capture Therapy (GdNCT). Firstly, superparamagnetic iron (II, III) oxide nanoparticles with a diameter between 10-15 nm were synthesized for use in the T2 agent and for magnetic targeting of the hybrid material. Subsequently, iron (II, III) oxide cores were coated with an inert silica layer between 15-20 nm, thereby enhancing their effectiveness as T1 agents in simultaneous MRI applications. By providing the formation of a layered Gdhydroxide structure on the core in the presence of different surfactants, the effect of surfactants on the formation of magnetic core-based Gd-hydroxide hybrid materials was investigated. The use of cetyltrimethylammonium bromide (CTAB) surfactant resulted in the synthesis of a highly crystalline and homogeneous hybrid material. Borate entrapment by use of ammonium tetraborate and boron-10 oxide in the prepared magnetic core-based layered Gd-hydroxide hybrid materials (Fe3O4@SiO2-GdLH-TB, and Fe3O4@SiO2GdLH-BI) was performed for simultaneous use with the GdBNCT to increase the effectiveness of the treatment. The prepared hybrid materials did not cause a significant cytotoxic effect on the T98G glioblastoma cancer cell line and human dermal fibroblast (HDF) cell lines, even at concentrations of 100 mu g/mL. Consequently, Fe3O4@SiO2-GdLH-TB and Fe3O4@SiO2-GdLH-BI hybrid materials may serve as promising agents for cancer diagnosis and treatment
Yüksek yağlı diyetle beslenen sıçanlarda diyete ilave edilen lutein ve zeaksantinin lipid peroksidasyonu, gen ekspresyonu ve kardiyometabolik risk faktörleri üzerine etkisi
No full textMitochondria targeted hydrogen sulfide donor AP39 attenuates allergic airway inflammation and airway hyperreactivity in mouse
No full textBackground: Asthma is a multifactorial chronic inflammatory airway disease affecting 5 % of children and 10 % of adults and there is no curative treatment. Recent studies have revealed that mitochondrial dysfunction is an important contributor to the pathophysiology of various respiratory diseases. Objectives: In this study, the effect of AP39, a mitochondria-targeted slow-releasing hydrogen sulfide (H2S) donor, was investigated in a mouse model of ovalbumin (OVA)-induced allergic asthma. Methods: Pulmonary function (airway resistance and dynamic compliance), inflammatory cells and cytokines in bronchoalveolar lavage (BAL) fluid, and histopathology of the lungs were evaluated in 8-12-week-old female C57BL/6 mice. Results: The OVA-induced allergic asthma model resulted in bronchial hyperreactivity, inflammatory cell infiltration in peribronchial and parenchymal areas in the lungs, increased Th2 cytokines and eosinophil numbers in BAL fluid. Treatment with AP39 (1000 nmol/kg) prevented bronchial hyperreactivity and suppressed the elevated IL-4, IL-5 and IL-13 cytokine levels, inhibited the increase of lymphocyte and eosinophil cells, and reduced histopathological changes in lung tissue. Treatment with a lower dose of AP39 (250 nmol/kg) had slightly less but still significant effects on bronchial hyperreactivity, inflammatory cells and histopathological changes, yet had no effect on cytokine levels. Conclusion: AP39 treatment prevented pathophysiological changes in allergic airway inflammation. Therefore, targeting the mitochondria with H2S donors may be a promising therapeutic potential in allergic respiratory diseases
