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Association of skin autofluorescence and carotid intima-media thickness in acromegaly patients
No full textBACKGROUND: The Pituitary Tumors Centers of Excellence (PTCOE) concept was established to provide a multimodal approach with careful management of comorbidities. Acromegaly, one of the main concerns of PTCOE per se, leads to increased mortality rates of which cardiovascular disease is an important cause. Increased skin autofluorescence (SAF) was shown to be associated with carotid intima-media thickness (CIMT), a well-established marker of atherosclerosis, and consequently cardiovascular complications. This study aimed to evaluate SAF and CIMT in association with anthropometric, clinical, and biochemical parameters in acromegaly patients and healthy controls. METHODS: The study group included 138 acromegaly patients and 127 healthy controls from the Department of Endocrinology and Metabolism Disease, Marmara University Medical School. Growth hormone, insulin-like growth factor I, lipids, glucose, insulin levels were assessed. Advanced glycation end products (AGEs) were measured by the auto-fluorescence reader. CIMT was measured from the common carotid artery wall on B-mode ultrasound. RESULTS: CIMT and SAF levels were significantly higher in the acromegaly group than the control group. There was a positive correlation between SAF and CIMT both in the total cohort and acromegaly patients. The presence of acromegaly, age, and SAF were the determining factors of CIMT in the whole study cohort. CONCLUSIONS: Our study is the first to examine the relationship between SAF and CIMT in acromegaly patients. We found higher CIMT and enhanced SAF in the acromegaly group compared to the control group with a significant positive correlation in between. The presence of acromegaly was related to increased SAF levels and CIMT. SAF was associated with CIMT in acromegaly patients. Implementation of CIMT and SAF evaluation in this clinical setting may improve cardiovascular complications, particularly in the PTCOE
Automating Faithful Finance: An AI Framework for Shariah-Compliant Disclosure in The Middle East
No full textAHP-Based Evaluation for Key Performance Indicators in Logistics Transfer Centers
No full textLogistics operations involve complex activities such as transportation, storage, and distribution of materials throughout the supply chain. These activities are critical managerial processes that enhance customer satisfaction, operational efficiency, cost-effectiveness, and ultimately the competitiveness of the business. The aim of this study is to identify key performance indicators for logistics operations and determine the levels of importance as-sociated with them. The identified importance levels will provide support to decision-makers in logistics network design and help logistics businesses better manage their operations. The indicators identified through a literature review have been weighted using the Analytic Hierarchy Process (AHP) method. The analyses revealed that performance metrics such as “Order Accuracy” and “Shipping Time” have emerged as prominent factors, with cost-related criteria such as “Inventory Cost” and “Distribution Cost” also holding high priority
Determination of glucose impurities in glucose-salt complex pharmaceutical products by HPLC-RID method: Analytical method development and validation study
No full textPharmaceutical products containing glucose and salt are widely used in the health sector and play a vital role. These pharmaceutical products are usually encountered as a part of drugs used in treatment and medical procedures. However, the analytical determination and quantification of active ingredients and impurities belonging to active ingredients in such products is a complicated process. This is because the retention time of impurities belonging to the glucose molecule in these pharmaceutical structures and the presence of salts that give peaks in similar places complicate the analysis process. Moreover, when the British Pharmacopoeia (BP), European Pharmacopoeia (EP) and US Pharmacopoeia (USP) are examined, it is seen that there are only monographs belonging to glucose raw material and there is no record regarding the determination of impurities belonging to glucose in pharmaceutical products containing glucose-salt complex structures. A new method has been developed within the scope of the study to prevent this complexity. As a result of the method development studies, the specific solvent method was optimized and a relatively simple pre-purification process with high recovery was applied to avoid salt interference. In addition, high-precision determination and validation studies of glucose and its impurities were carried out using the High Performance Liquid Chromatography-Refractive Index Detector (HPLC-RID) method. This new analytical approach is expected to contribute to the development of reliable and high-quality products in the healthcare field by raising industry standards
TÜRK MÜZİĞİ NAZARÎ KAYNAKLARINDA REHAVİ MAKAMI VE KANTEMİROĞLU EDVARINDA YER ALAN REHAVİ VE RAST MAKAMLARINDAKİ ESERLERİN ANALİZİ
No full textBu çalışma; Dimitrie Cantemir’in kaleme aldığı, Yalçın Tura’nın tıpkıbasımınıyaptığı Kitâbu İlmi’l-Mûsikî alâ Vechi’l-Hurûfât adlı eserinde “İsmi Olup CismiOlmayan” makam Rehâvî’yi konu almaktadır. Kantemioğlu’nun Rehâvî makamınıtanımlarken kullanmış olduğu dikkat çekici bir ifade olan “İsmi Olup Cismi Olmayan”tanımlaması ve makam tasnifi, çalışmanın ana çıkış noktasıdır. Kantemiroğlu’nunmakam hakkında neden böyle düşündüğü anlaşılmaya çalışılmış; makamın yapısıKantemiroğlu’nun vermiş olduğu tanımlar ışığında incelenmiş, bu tanımlarla geçmişdönemdeki edvarlarda Sistemci Okul takipçilerinin Rehâvî makamı tarifleriincelenmiştir. Ayrıca Sistemci Okul takipçisi olmayan XX. ve XXI. yüzyılteorisyenlerinin vermiş olduğu Rehâvî makamı tanımları da incelenmiştir.Günümüzde yaygın olarak kullanılan Arel-Ezgi-Uzdilek müzik teorisi sistemi ileedvardaki tüm Rehâvî eserlerin analizi yapılmıştır. Ayrıca Kantemiroğlu’nunedvarında bulunmayan ve bestesi Kantemiroğlu’na ait birer adet Rehâvî peşrev veRehâvî saz semaisi yine aynı yöntem ile analiz edilmiştir. Kantemiroğlu’nun Rehâvîmakamının Râst makamıyla olan benzerliğine dair iddiası doğrultusunda edvardanseçilen beş Râst örnek eser de analiz edilmiş ve bu eserlerin Rehâvî makamındakieserler ile mukayesesi yapılmıştır.Bu çalışma altı bölümden oluşmaktadır. Birinci bölüm çalışmanın giriş kısmınıoluşturmaktadır. İkinci bölümde; Kantemiroğlu’nun hayatı ve yaptığı çalışmalarincelenmiştir. Üçüncü bölümde; Kantemiroğlu Edvarı’nın bölümleri hakkındabilgilendirme yapılmıştır. Dördüncü bölümde; Rehâvî makamı tarihsel süreç içindeincelenmiştir. Beşinci bölümde; Rehâvî eserlerin makamsal analizi yapılmıştır. Altıncıve son bölümde; seçilen Râst eserlerin makamsal analizi yapılmıştır.This study, Kantemiroğlu's Edvar focuses on the makam Rehâvî, which isdescribed as “having a name but no body” in the treatise Kitâbu İlmi’l-Mûsikî alâVechi’l-Hurûfât, authored by Dimitrie Cantemir and published in facsimile by YalçınTura. The striking characterization “having a name but no body” used by Cantemir todefine the Rehâvî makam, along with his classification of makams, constitutes themain point of departure for this research. The study aims to understand why Cantemirmade such a claim regarding this makam. The structure of the makam is examined inlight of Cantemir’s definitions, and these descriptions are compared with those foundin earlier edvar treatises written by theorists of the Systematic School. Additionally,definitions of the Rehâvî makam provided by non-Systematic School theorists of the20th and 21st centuries are also reviewed. All Rehâvî compositions included inCantemir’s edvar are analyzed using the widely accepted Arel-Ezgi-Uzdilek musictheory system. Furthermore, a Rehâvî peşrev and a saz semâîsi composed by Cantemir,which are not found in the edvar, are analyzed using the same method. In accordancewith Cantemir’s assertion regarding the resemblance of Rehâvî to the Râst makam,five sample compositions in the Râst makam selected from the edvar are also analyzedand comparatively evaluated alongside the Rehâvî works.This study consists of six chapters. The first chapter presents the introduction.The second chapter examines the life and works of Cantemir. The third chapterprovides information about the structure of the edvar. The fourth chapter explores thehistorical development of the Rehâvî makam. The fifth chapter includes a modalanalysis of Rehâvî compositions, and the sixth and final chapter offers a modalanalysis of the selected Râst compositions.</p
Charged-particle multiplicity distributions over a wide pseudorapidity range in p–Pb collisions at sNN=5.02 TeV
No full textThis paper presents the primary charged-particle multiplicity distributions in proton–lead collisions at a centre-of-mass energy per nucleon–nucleon collision of sNN=5.02 TeV. The distributions are reported for non-single diffractive collisions in different pseudorapidity ranges. The measurements are performed using the combined information from the Silicon Pixel Detector and the Forward Multiplicity Detector of ALICE. The multiplicity distributions are parametrised with a double negative binomial distribution function which provides satisfactory descriptions of the distributions for all the studied pseudorapidity intervals. The data are compared to models and analysed quantitatively, evaluating the first four moments (mean, standard deviation, skewness, and kurtosis). The shape evolution of the measured multiplicity distributions is studied in terms of KNO variables and it is found that none of the considered models reproduces the measurements. This paper also reports on the average charged-particle multiplicity, normalised by the average number of participating nucleon pairs, as a function of the collision energy. The multiplicity results are then compared to measurements made in proton–proton and nucleus–nucleus collisions across a wide range of collision energies
A Fuzzy Inference Model Proposal for ESG Scores Measurement of BIST Sustainability 25 Index Companies
No full textEnvironmental, Social, and Governance (ESG) criteria have become essential indicators that not only assess a firm’s sustainability performance but also directly influence long-term financial success, risk management processes, and stakeholder trust. The ESG score presents a detailed analysis of a firm's environmental, social, and corporate governance factors, serving as a key decision-making tool for investors, regulatory bodies, and other stakeholders. Numerous international organizations and data providers calculate and publish these scores. One such institution, LSEG Data & Analytics, determines ESG scores by applying sector-specific weightings for environmental, social, and governance categories, providing a more tailored evaluation process. However, ESG assessments often involve uncertainties, qualitative data, and subjective judgments, which may limit the effectiveness of traditional evaluation methods. Unlike conventional ESG scoring methodologies, the fuzzy inference approach can more effectively account for intersectoral differences. Instead of assigning separate weightings to the environmental, social, and governance categories, this study proposes a unified rule base that ensures a consistent and adaptable evaluation framework across different industries. This paper presents a fuzzy logic-based inference model to assess the ESG score of firms included within the BIST Sustainability 25 Index