KYOTO GAKUEN UNIVERSITY ACADEMIC REPOSITORY
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The Present State of the Hyperthermia in Japan,and by What Kind of Way Should We Progress from Now on?
No full textHyperthermia has a long history as a treatment modality for tumors, with the rapid development of heating devices for hyperthermia starting more than a century ago. Ideal heating devices would enable the targeted area to be heated in accordance with the depth and width of the tumor.
However, hyperthermia alone does not show attractive results for cancer patients, but does appear to reinforce many therapeutic options, especially against for liver cancer. Hyperthermia is a potent sensitizer for radiotherapy, chemotherapy, and immune therapy, each of which has significantly advanced in this decade. A multimodal treatment approach that relies on hyperthermia combined with state-of-the-art radiation, chemotherapy, and immune therapy can result in great clinical benefits for pancreatic cancer patients. In a prior study, we demonstrated that hyperthermia enhances the cytotoxicity of gemcitabine, one of the key drugs for pancreatic cancer, by inhibiting gemcitabine -induced activation of nuclear factor kappa B (NF-kB). Considering these results, combining
hyperthermia and chemotherapy could result in better treatment outcomes for pancreatic cancer patients.
Hyperthermia may reduce the metastatic potential of cancer cells and inhibit tumor metastasis.
However, the underlying mechanisms through which hyperthermia inhibits cancer metastasis have yet to be fully elucidated. Epithelial-to-mesenchymal transition (EMT) plays a key role in tumor metastasis; therefore, we investigated and summarized the effects and underlying mechanisms of EMT in cancer cells. The results suggest that hyperthermia not only inhibits tumor growth, but also mediates the expression of EMT-related genes̶including E-cadherin and vimentin. Elevated body temperature has been thought to play an important role in the regulation of immune responses,
and accumulating evidence in thermal medicine indicates that hyperthermia could be a useful combination therapy to enhance the efficacy of cancer immunotherapy.
I believe that, in the years to come, a stronger focus on the research and development of these novel yet safe modals is what is required for a treatment breakthrough to emerge that ultimately results in longer survival and higher quality of life for many cancer patients.departmental bulletin pape
Department of Nursing, Faculty of Health and Medical Sciences, Kyoto Gakuen University
No full text目的 健康な乳幼児の母親を対象とした育児支援事業（以下事業）の文献検討を通して事業の効果を明らかにすると共に、厚生労働省推進の事業展開と照らし合わせ今後の課題を探る。
方法 医中誌Web Ver.5ADVANCED を用い、1997 年から2015 年までの文献を対象に「育児」、「孤立」、「支援」をキーワードに検索し、「原著論文」にて絞込検索を行った。また「育児支援事業」「原著論文」で同様に絞込検索を行い、対象文献の内容を検討した。文献は、健常な乳幼児の母親を対象とする研究とした。
結果 対象文献は10 件であった。地域子育て支援拠点事業の4 つの基本事業で分類すると、6 件は複数事業を同時展開し残り4 件は単独事業の実施であることが明らかとなった。
考察 事業実施の効果を評価した文献が少ないこと、支援では地域子育て支援拠点事業の基本事業を複合することで、事業個々の利点の相乗効果を期待できること、地域連携や情報提供の方法等で課題があることが示唆された。departmental bulletin pape