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Chitosan-Based Delivery Systems Loaded with Glibenclamide and Lipoic Acid: Formulation, Characterization, and Kinetic Release Studies
No full textGlibenclamide and lipoic acid are two drugs frequently recommended for the management of diabetes mellitus, and so, the development of a new formulation containing both substances has a great benefit in terms of efficiency and compliance, acting also as a multi-target drug system. Accordingly, the aim of this study was the formulation and physicochemicalcharacterization of new polymeric systems based on chitosan (CS) in whose matrix were encapsulated glibenclamide (Gly) and lipoic acid (LA). The polymeric systems were prepared as microparticles (CS–Gly, CS–LA, and CS–Gly–LA) through ionic gelation method, using pentasodium tripolyphosphate (TPP) as crosslinking agent. The polymeric systems obtained were characterized in terms of particle size and morphology, IR spectroscopy, entrapment efficiency and drug loading, swelling degree, and therelease of the active substances from the chitosan matrix. The polymeric systems obtained were stable systems; the presence of glibenclamide and lipoic acid into the polymer matrix were proved by IR spectroscopy. The entrapment efficiency was 94.66% for Gly and 39.68% for LA. The developed polymeric systems proved a favorable swelling degree and drug release profile, the percentage of release being 88.68% for LA and 75.17% for Gly from CS–Gly–LA systems
Metabolic parameters in piglets reared in different conditions of microclimate
No full textThe aim of the work is to clarify the changes in the level of nonspecific natural resistance, indicators of the biochemical composition of blood, the intensity of growth of piglets grown in different microclimates. Two boxes designed for growing 300 piglets (from birth to 60 days of age) in each were identified for research. Piglets of the control group were kept on electrically heated floors, experimental – in machines with heated electric heaters with supply of fresh air to each box at the rate of 35-40 m3/h/kg live weight. The state of the microclimate was assessed by physical parameters, chemical composition and total bacterial contamination of the air. Criteria for the evaluation of health status of piglets was morphological, biochemical and immunological indicators of blood, such as bactericidal activity of blood serum (BASB); lysozyme activity blood serum (LASB); cellular factors of protection. For tests of general resistance of piglets were taken – live weight, morbidity and survival, which were controlled by weighing and daily accounting at different ages (15, 30, 60 days). Maintaining piglets in comfortable and uncomfortable conditions of the microclimate revealed a decrease in rod neutrophils and an increase in lymphocytes, a decrease in the ratio of lymphocytes to neutrophils. In animals grown in uncomfortable conditions (experimental), a decrease in total protein by 3.64 %, albumins – by 6.44 %, and globulins – 51.05 % (15-day age), 56.37 % (30-day), 63.5 % - (60-day) was established. Studies have shown that piglets from the control of the enzyme activity of blood (ALAT) superior to 60 - day-old analogues from the experience of 5.1 %, ASAT – 7.4 % (p≤ 0.05). The level of total glutathione in the control was 24.2 g/% (15 -day) and 18.7 % (60-day age), or respectively lower by 12.6 % and 4.5 % in the experience group (p≤ 0.05), which caused a decrease in the immune and antioxidant capacity of piglets caused by the high content in the air of the experimental box of harmful gases and microflora
Research on optimization working process for cutting of agricultural plants at the time of recovery
No full textCaracterizarea antioxidantă şi cromatică a conţinutului fenolic din varza roşie
No full textRed cabbage is a widely consumed vegetable, with a high content of health-promoting compounds:minerals, vitamins, phenols and glucosinolates. The phenols group is very well represented and includes, among others, the anthocyanin pigments, which are responsible for the specific colour of red cabbage. The present research analyses the total and individual phenolic content (measured spectrophotometrically and, respective, by HPLC), the total and monomeric anthocyanins content, the chromatic parameters (colour density, polymeric colour, percent of polymeric colour, browning index, the CIELab colour parameters: lightness, green/red colour component, blue/yellow colour component, colour intensity, tone), the antioxidant activity, as well as the pH of an ethanolic red cabbage extract. The results revealed a high content of phenolic compounds and an important antioxidant activity. The main phenols identified are: gallic acid, ellagic acid, procyanidin B1, m-hydroxybenzoic acid, ferulic acid and protocatechuic acid. The results provedan important quantity of anthocyanins, of which 82.59% are monomeric. The values of polymeric colour, percent of polymeric colour and browning index confirm the preponderance of monomeric phenols in the studied red cabbage extract
Influenţa unor intervenţii tehnologice asupra compoziţiei chimice a strugurilor, în vederea utilizării lor ca măsuri de adaptare a viticulturii la schimbarea climatică
Get PDFClimate change influences viticulture by changing the topoclimate of the
vineyards, the phenology of grapevine and the chemical composition of the grapes.
Areas unsuitable for viticulture have started to acquire viticultural potential, while
others are negatively affected. Research to date indicates that Cotnari vineyard is
among the regions favored by climate change: the vineyard's potential has changed in
terms of increasing areas favorable for the production of quality white wines and the
creation of conditions for red wine production. This researchaims to establish the
influence of some cultural practices on the chemical composition of grapes for the
Tămâioasă românească variety, aiming to use them asadaptation measures to climate
change. The evolution of the grapes ripening was studied for three different
experimental variants: defoliation applied at the base of the shoots; the defoliation of
the middle third of the shoots; and shading vine leaves by bentonite film. The results
indicate taht: the lowest accumulations of sugars is registered in the control variant,
no de-leafing measure applied (173.8 g / L) while the largest is found in grapes where
the shoots were stripped free of leaves at their base (216.0 g / L); an effect of reducing
the sugar content when shading with bentonite film at a concentration of 6% (206.8 g /
L), increasing the pH (3.91) and decreasing the titratable acidity (5.0 g / L ac. tartaric)
was registered . The values obtained provide indications of the effect of different
interventions on the composition of grapes and their suitability as measures to adapt to
climate change, and experiences will be continued and diversified in the coming years
The influence of treatments with various phytosanitary products (fungicides) on the attack of some phytopathogenic fungi on wheat harvest - Pitar Romanian variety - in 2019 pedoclimatic conditions of the Eastern Baragan
No full textThis study aims at monitoring the dynamics of the occurrence and evolution of the attack of some pathogenic agents to Romanian wheat variety, Pitar. Among these, we mention: Puccinia recondita f. sp. tritici (sin. Puccinia triticina) which produces wheat’s brown rust and Septoria spp. which produces wheat’s brown leaf spotting (septoriosis). Also, the influence of applying these fungicides on the harvest, as compared to the untreated control variant, was monitored. One experiment with 7 variants (6 variants with phytosanitary treatment, plus one control variant not treated) was taken into consideration for this study, for which the following phytosanitary products were used, as follows: FALCON PRO (prothioconazole 53 g/l + tebuconazole 148 g/l + spiroxamine 224 g/l), MYSTIC 250 EC (tebuconazole 250 g/l) and CAPALO (fenpropimorph 200g/l, epoxiconazole 62.5 g/l, metraphenon 75g/l). The treatment variants were the following: V1 - MYSTIC 250 EC 0.5 L/HA, 1 treatment applied at spike’s releasing (17.05.2019); V2 - MYSTIC 250 EC 0.5 L/HA, 1 treatment applied at straw’s extension (27.04.2019) + 1 treatment applied at kernel’s filling (8.06.2019), V3 - FALCON PRO 0.6 L/HA, 1 treatment applied at spike’s releasing (17.05.2019), V4 - FALCON PRO 0.6 L/HA, 1 treatment applied at straw’s extension (27.04.2019) + 1 treatment applied at kernel’s filling (8.06.2019), V5 - CAPALO 1.0 L/HA, 1 treatment applied at spike’s releasing (17.05.2019), V6 - CAPALO 1.0 L/HA, 1 treatment applied at straw’s extension, (27.04.2019) + 1 treatment applied at kernel’s filling (8.06.2019), V7 - Untreated control
variant. The experiment was placed in Latin square, the 7 variants being placed in 7 repetitions. Among the pathogenic agents under monitoring, Puccinia recondita f.sp. tritici fungus producing the brown rust had produced the greatest attacks. The attack of the fungi from Septoria sp. variety producing leaf’s brown rust (septoriosis) and from Blumeria
(Erysiphe) variety, producing wheat’s mildew, was rare. The first two leaves placed under the spike had been analyzed for the above. These observations had led to the conclusion that for all 6 treatment variants, the degree of attack (D.A. %) of Puccinia recondita f.sp. tritici fungus was more reduced than at the untreated control variant. The harvests of the
treated variants were as follows: (V1 – 6989 kg/ha, V2 - 6688 kg/ha, V3 - 6536 kg/ha, V4 - 6828 kg/ha, V5 - 6875 kg/ha, V6 - 6582 kg/ha and V7 (control variant not treated) - 6301 kg/ha
Optimization of sweet potato (Ipomoea batatas L.) in vitro cultivation by using the contaminated cultures for obtaining new shoots in greenhouse conditions
No full textThe artificial media used for plant tissue cultures contains numerous nutrients that can create favorable conditions for
the development of pathogens. As antibiotic use is not encouraged, a new strategy has been tried to reduce the losses
caused by the presence of microbial infections in "in vitro" cultivation of sweet potato. This consisted in the
transplantation in greenhouse conditions of sweet potato plantlets from contaminated "in vitro" cultures, in order to
obtain new shoots. Five sweet potato varieties were used in this study, and two types of substrate for planting: pearlite
and a mixture of peat and pearlite (1:1). The survival rate of the plantlets was 100% on the substrate consisting only of
pearlite. The surviving sweet potato plants had a rapid growth rate, the greenhouse conditions being favorable for this
culture. Approximately two months after transplantation, the obtained shoots could be used as a source of explants to
initiate new "in vitro" cultures. Regarding the number of shoots the highest value was obtained by the Yulmi variety.
The length of the shoots varied according to the variety, thus the highest value was recorded by the KSC1 variety (98.30
cm) . The number of buds/shoot is strongly influenced by the variety. In some sweet potato varieties the distance
between buds is smaller, and in others larger, this being a characteristic of the variety. Regarding this trait the best
results were obtained in Juhwangmi variety. By applying this method, the process of sweet potato "in vitro"
multiplication becomes more economically efficient. After only a few weeks under greenhouse conditions, involving
minimal costs, many shoots can be obtained
Electrozi serigrafiaţi ca instrumente de monitorizare “laborator-intr-un-cip” pentru capacitatea antioxidantă a alimentelor
No full textThe necessity for fast, accessible and reliable information in a
complex-connected world generated in the last 40 years an impressive
development of the "lab-on-a-chip" type technology based on miniaturized
devices able to integrate in a single chip, one or several analyses. The areas of
application for such type of devices are various, ranging from clinical
diagnostic to evaluations of food substrates or environmental monitoring. The
capabilities of "lab-on-a-chip" can be extended beyond the quasi-limited
classical monitoring, thus providing valuable chemical and biological
information that can be digitized by using centralized/decentralized facilities for
data storage, remotely, thus being more easily available to users. The "lab-ona-
chip" materials and manufacturing technologies present net advantages (low
cost, high parallelization, ease of use and compactness, reduction of human
error, faster response time and diagnosis, low volume samples) but also and
some limitations (miniaturization increases the signal-to-noise ratio so that
most "lab-on-a-chip" technologies are not yet ready for industrialization, the
mandatory external control system expands the final size and costs, the
widespread accessibility can generate erroneous fears for an untrained public)
Utilizarea sticlei în amenajarea spaţiului verde din faţa universităţii A. I. Cuza
Get PDFThe paper highlights the different uses of glass through its decorative qualities and finding a landscaping solution to meet the needs of the green space proposed for landscaping in a bachelor's project in Landscape specialization at the Faculty of Horticulture of the U.S.A.M.V. Iasi. In the proposed solution, the functions and position of the analyzed space within the university urban ensemble were taken into account, for its harmonious integration; respectively were brought in the area arranged for socializing as well as for relaxation and rest, introducing pieces of urban furniture adapted to the current requirements, through the endowments of connectivity to the online environment and to renewable energy sources (photovoltaic panels) in their composition, being thus suitable for a modern outdoor space dedicated to students and all passers-by. Geometric style proposed is in accordance with the architectural style of nearby buildings