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Apiaceae essential oils: boosters of terbinafine activity against dermatophytes and potent anti-inflammatory effectors
Get PDFDermatophyte infections represent an important public health concern, affecting up to 25%
of the world’s population. Trichophyton rubrum and T. mentagrophytes are the predominant dermatophytes
in cutaneous infections, with a prevalence accounting for 70% of dermatophytoses. Although
terbinafine represents the preferred treatment, its clinical use is hampered by side effects, drug–
drug interactions, and the emergence of resistant clinical isolates. Combination therapy, associating
terbinafine and essential oils (EOs), represents a promising strategy in the treatment of dermatophytosis.
In this study, we screened the potential of selected Apiaceae EOs (ajowan, coriander, caraway,
and anise) to improve the antifungal activity of terbinafine against T. rubrum ATCC 28188 and T. mentagrophytes
ATCC 9533. The chemical profile of EOs was analyzed by gas chromatography. The
minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) of EOs/main
compounds were determined according to EUCAST-AFST guidelines, with minor modifications. The
checkerboard microtiter method was used to identify putative synergistic combinations of EOs/main
constituents with terbinafine. The influence of EOs on the viability and pro-inflammatory cytokine
production (IL-1b, IL-8 and TNF-a) was determined using an ex vivo human neutrophils model. The
binary associations of tested EOs with terbinafine were found to be synergistic against T. rubrum,
with FICI values of 0.26–0.31. At the tested concentrations (6.25–25 mg/L), EOs did not exert cytotoxic
effects towards human neutrophils. Anise EO was the most potent inhibitor of IL-1b release
(46.49% inhibition at 25 mg/L), while coriander EO displayed the highest inhibition towards IL-8
and TNF-a production (54.15% and 54.91%, respectively). In conclusion, the synergistic combinations
of terbinafine and investigated Apiaceae EOs could be a starting point in the development of novel
topical therapies against T. rubrum-related dermatophytosis
Fly ash magnetic adsorbent for cadmium ion removal from an aqueous solution
No full textThe fly ash generated from
a Romanian power plant was used as a
starting material in this study. The aim of
the study was to obtain a low cost
material based on the treatment of fly ash
with Fe3O4 for utilization as an adsorbent
for cadmium ion removal. The adsorbent
that was synthesized was characterized
using different techniques. The adsorption
process was investigated by the batch
technique at room temperature. The
quantity of cadmium ion adsorbed was
measured spectrophotometrically. The
experimental data showed that the
material can remove cadmium ions at all
three working concentrations. The
adsorption capacity increased with an
increase in concentration, respectively
contact time. The results were analyzed
through two kinetic models: pseudo first
order and pseudo second order. The
kinetics results of cadmium adsorption
onto a magnetic material are in good
agreement with a pseudo second order
model, with a maximum adsorption
capacity of 4.03 mg/g, 6.73 mg/g, and
9.65 mg/g. Additionally, the pseudo
second order model was linearized into its
four types. The results indicated that the
material obtained show the ability to
remove cadmium ions from an aqueous
solution
Automatizarea procesului de construire a mobilerului destinat repaosului dintr-o grădină
Get PDFBenches are furniture elements from a garden that permit relaxation and resting. They can have various shapes and may be built from different materials. In this paper, the authors present a study referring to the possibility of design automatization of these furniture' elements using the interface named iLogic that is a programming interface included in the Inventor software. In the end, the authors present the conclusions they reached and some recommendations regarding the use of the iLogic interface for benches design
Sustainable management of mango nutrition for better yield and quality
No full textOptimum supply of macro
and micronutrients is of critical
importance in improving the yield and
quality of horticultural crops. Alike, the
quality and yield of mango plants
significantly increase by balanced
application and uptake of macro and
micronutrients. However, soil type and
characteristics are important factors that
directly influence the bio-availability of
these nutrients to the plants. In addition,
variability in climate has an impact on
mango yield in the current scenario. Many
scientists have found that mango
cultivation in saline soils is a major
obstacle to achieving the desired yield and
improving quality. Overdose of
fertilization is the major factor for the
development of saline soils, furthermore,
rise in climate temperatures is also a
major factor. Therefore, to overcome this
problem, nutrient management and the
use of balanced fertilizer are the important
factors to be controlled. Thus, this review
focuses on the performance and
importance of essential macro and
micronutrients to improve the yield and
quality of mango fruits. To understand the
effective use of macro and micronutrients,
the positive and negative impacts of the
nutrients are explained. It is suggested
that analyzing the soil, mango fruits, and
mango plant leaves for their nutrient
status can be useful to formulate
fertilization strategies for higher fruit
production and quality. Research and
development, along with agricultural
extension, should focus more on
introducing genetically effective mango
varieties to improve nutrient and water
utilization efficiency
Observații privind dăunătorii semnalați în plantațiile viticole și protecția fitosanitară a acestora în anul 2021
Get PDFThe introduction and generalization of the integrated system for the protection of vines is intended to limit the factors leading to the deregulation of natural biological balance. Pesticides, an indispensable component of this system, are a means of combating pathogens and pests in wine-growing. Their efficient use requires integrated management at farm level or even at plot level. A phytosanitary program established at the level of the plot in a demonstration batch shall confirm by the results of the new trends in sustainable viticulture
Influence of different commercial yeasts on volatile fraction of sparkling wines
Get PDFThe occurrence of aroma constituents in sparkling wines, with direct impact on their
organoleptic characteristics, is affected by several factors, for example the base-wine particularities,
grapes cultivar conditions, inoculated yeasts, the aging stage, and wine-making practices. This study
evaluated the influence of different four commercial yeasts (IOC FIZZ™, IOC DIVINE™, LEVULIA
CRISTAL™, and IOC 18-2007™) on the volatile composition of experimental sparkling wines. For this,
five sparkling wines variants from the Muscat Ottonel grape variety were obtained. The base-wine
was obtained through reverse osmosis and had a predetermined alcoholic concentration (10.5% vol.).
In order to fulfill the proposed purpose, the experimental sparkling wines were characterized by the
physical–chemical parameters (according to International Organization of Vine and Wine methods of
analysis), volatile fraction (using gas-chromatography coupled with mass spectrometry technique),
and sensory descriptors. Data showed a key impact on the concentration of the volatile constituents
(p < 0.05), depending on the type of inoculated yeast for the second fermentation. Regarding the
sensory analysis, important differences can be observed due to the type of inoculated yeast. Only a
minor influence on the physical–chemical parameters was registered
Flood risk assessment for the Prut river hydrographic basin in Romania
No full textThe eastern part of Romania is frequently affected by floods. The flood regime in the Prut river catchment is
characterised by short, high intensity intensity rainfall, coupled with low infiltration in the soil, that lead to flash
floodings in the upland areas. The upper cathcment is controlled by the Stanca-Costesti reservoir that grately influences
the flow regime and decreseas significantly the flood risk for the downstream areas. Significant floods were recorded
during 2005 – 2020, with istoric maximum flows and total volumes. Through successive discharges of different
downstream flows, safe transit of volumes was achieved, without endangering downstream objectives. This paper
presents a comparative study of the maximum flows registered at the hydrometric stations and flood propagation times
between the succesive control sections. In order to maintain the safe operation of the defense lines on the Prut River (the
dykes), the personnel of Water Basinal Administration Prut – Barlad carried out immediate interventions at the critical
points highlighted on the embankment network (infiltrations, erosions, areas under the projected elevation, under
passages), depending on their seriousness and their negative effects. This paper can be used to further improve the
existing basinal flood defence plans
Effects of salinity on growth and proline content on bean and alfalfa
No full textSoil salinity is a major
agricultural constraint in many countries.
Plants’ response to salinity depends on the
species and the salt concentration in the
soil. The objective of this study was to test
the resistance of three leguminous plants -
common bean (variety ‘El-Jadida’), broad
bean (variety ‘Claro de Luna’), and alfalfa
(variety ‘Diamon’) - to several salinity
rates and to show which one was more
resistant to salt stress. This study was
carried out under controlled conditions,
with six NaCl concentrations (0, 1, 3, 6,
and 9 g/kg) added to a mixture of potting
soil and sand. A completely randomised
design was used, where the three legumes
were cultivated with different salt
concentrations to determine the effect of
these doses on fresh biomass, dry mass,
and physiological parameters (sodium and
proline content). The results showed the
negative effect of salinity on fresh biomass
and dry mass of shoots and roots. Claro de
Luna, the broad bean variety, was more
adapted to salinity than alfalfa and
common bean. The amount of sodium in
the shoots and roots of the three species
increased with increasing salinity. Alfalfa
may play a role in soil desalination; at
53.33 mM NaCl, 100 mg alfalfa dry mass
absorbed 4.5 mg Na per pot, which
corresponded to the uptake of about 0.6 kg
Na per hectare of soil. Proline content
increased with increasing salt
concentrations
The parasites of some Asian carp species from the aquatic biotopes from the Republic of Moldova
Get PDFAs a result of the parasitological examination of some Asian carp species (common carp, prussian carp, silver carp, bighead
carp) from a few fish ponds from Falești district, 14 species of parasites were found, systematically classified into
7 classes, 12 families, 14 genera. The degree of infestation varied depending on the species: Trichodina sp. - common
carp (EI-53.84%, II 1-10 ex.); Dactylogyrus sp. - common carp (EI-92.0%, II-1-45 ex.), prussian carp (EI-100%, II-1-45
ex.), silver carp (EI-72.7%, II-12-81 ex.), bighead carp (EI-100%, II-74-160 ex.); Eudiplozoon nipponicum - common
carp (EI-38.46%, II-1-7 ex.), prussian carp (EI-16.0%, II-1-2 ex.); Khawia sinensis - common crap (EI-46.15%, II-1-15
ex.); Schyzocotyle acheilognathi – bighead carp (EI-9.09%, II-1 ex.); Valipora campylancristrota - common carp (EI-
7.69%, II-1 ex.), silver carp (EI-9.09%, II-1 ex.), bighead carp (EI-44.4%, II-1-3 ex.); Aspidogaster limacoides – prussian
carp (EI-4.0%, II-1 ex.); Diplostomum spathaceum - common carp (EI-30.76%, II-1-4 ex.), prussian carp (EI-20%,
II-1-8 ex.), silver carp (EI-54.5%, II-1-15 ex.), bighead carp (EI-100%, II-1-92 ex.); Posthodiplostomum cuticola -
common carp (EI-7.69%, II-1-2 ex.), silver carp (EI-54.5%, II-5-12 ex.); Phillodistomum sp. – prussian carp (EI-0.25%,
II-1 ex.); Phylometroides sanguinea – prussian carp (EI-4.0%, II-1-2 ex.); Sinergasilus lieni – silver carp (EI-72.7%, II-
7-26 ex.), bighead carp- (EI-100%, II-5-24 ex.); Lernaea sp. – common carp (1 ex.); Glochidium - common carp (EI-
7.69%, II-1-10 ex.), prussian carp (EI-4.0%, II-4 ex)
Pathologies of the liver and gallbladder at dogs and their imagistics – statistic analyses
Get PDFPathologies of the liver and gallbladder present very diversified clinical signs, needing additional exams, like imagistic
ones.
The radiological and ultrasonography exam represent the main imagistic methods for diagnosing this pathologies at
dogs. Radiography brings data regarding the shape and volume modification of the liver, without offering any
information about the gallbladder. Ultrasonograpy of the liver allows a more detailed examination of the internal
structure, including vascularization and the bile ducts. Ultrasonography is also useful in fine needle aspiration and
biopsy, as a non-invasive method of diagnosis.
The goal of this study was of analysing the prevalence of liver and gallbladder pathologies arriving at the Faculty of
Veterinary Medicine Iași, and their diverisity. A number of 177 pacients were examined between 2018 and 2020. All
the dogs undergone the ultrasonographic exam. During the examination, 62 pacients were diagnosed with modifications
at the level of the gallbladder while only 43 were diagnosed with modifications at the level of the hepatic parenchima