ePub (Univ. zu Lübeck)
Not a member yet
3401 research outputs found
Sort by
non-invasive analysis of vascular parameters
No full textDynamische Optische Kohärenztomographie Melanozytärer Läsionen : Nicht-invasive Analyse von GefäßparameternThe differential diagnosis of melanocytic lesions is of great importance due to the
rise in melanoma incidence, high morbidity and mortality in later stages and
demanding differential diagnosis, especially in early stages. Currently, by a clinical-
dermoscopic approach, early melanomas may be overlooked, the proportion of
melanomas and dysplastic nevi overestimated, and a significant number of
performed biopsies may be unnecessary.
This prospective, clinical, multicentre study investigated the potential of dynamic
optical coherence tomography (D-OCT) to distinguish melanocytic lesions based on
their microvascularisation. The study hypothesis was the existence of vascular
differences between nevi, dysplastic nevi, melanomas, adjacent skin and according
to potential influencing factors, including age, sex, and lesion location. The results
were compared to the current diagnostic gold standard of a clinical-dermoscopic
and histological examination. Further, to confocal laser microscopy and line-field
confocal optical coherence tomography.
With excellent predictive values, D-OCT distinguished nevi from melanomas.
Several significant and explainable differences were observed concerning nevus
subtypes, participant sex, age and lesion location but allowed no solely vascular-
based distinction. Based on our findings, we created an algorithm to standardise a
D-OCT-based differential diagnosis of melanocytic lesions.
Improving the current clinical-dermoscopic diagnostic approach and avoiding
invasive biopsies are central research interests. D-OCT visualises skin morphology
and vascularisation in vivo and in real time. Its non-invasive approach prevents
unnecessary biopsies, wound formation, infection, scarring and biopsy-related pain.
It has a high resolution and appropriate penetration depth. Scanning is quick,
handling is simple, and it is suitable for the skin of every ethnicity and all lesion
locations and architectures. Furthermore, it offers an individualised therapeutic
approach and a potentially earlier melanoma detection with a consequent reduction
of morbidity and mortality and an economic benefit.
Further confirmation by high-quality, multicentric studies is recommended. If
promising, a combinatory device with D-OCT, camera, and dermoscopy tool should
be considered for diagnosing (unclear) melanocytic lesions
Role of hormone receptors in controlling GSDME mediated-pyroptosis in breast cancer cells and its influence on the response to chemotherapy and anti-tumor immunity
No full text
Auswirkungen von Gentamicin und Fusidinsäure auf humane Schweißdrüsen-abgeleitete Stammzellen in vitro und auf deren wundheilungsfördernde Eigenschaften in einem humanen Ex-vivo-Modell
Get PDF
