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Exploring the Relationship between Vitamin D and Cardiovascular Health: An American NHANES Analysis
Get PDFDevelopmental pyrethroid exposure disrupts molecular pathways for circadian rhythms and synaptic plasticity in mouse brain
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Biographical Writing through the Lens of Lawrence A. Cremin’s Leadership and Presidency at Teachers College
Get PDFThis article examines the complexities of biographical writing through the lens of Lawrence Cremin’s (1925–1990) leadership and presidency at Teachers College, Columbia University. Cremin was president of Teachers College in the period 1974-1984 and a prolific author best known for his three-volume work American Education (published between 1970 and 1988). He was also a Professor of Education at Teachers College until his death in 1990. This article explores the subjectivity inherent in biographical writing, focusing on the ways in which archival research and personal reflection influenced the author’s evolving perceptions of Cremin. The article begins with a discussion of Cremin’s belief in the importance of educational thought that extended beyond formal schooling–an aspect that triggered the author’s initial interest in Cremin’s life and career. The narrative then focuses on Cremin’s presidency during a challenging time for higher education. Analysis revealed that as an institutional leader, Cremin struggled with shared governance approaches and consistently opted for isolated and autonomous administrative decisions rendered with the power of his position as president of the College. Throughout the article, the author describes his gradual discoveries of Cremin’s leadership experiences and complex beliefs, and emphasizes the uncertainty inherent in life-writing
Drug Identification and Repurposing in Lung Adenocarcinoma: Differences in Male and Female Subjects
Get PDFLung adenocarcinoma (LACA) presents with a range of debilitating symptoms, including chronic cough, hemoptysis, and shortness of breath. In this study, we reanalyzed a published transcriptomic dataset to compare male and female LACA samples with healthy lung tissue and identify potential therapeutic targets capable of reversing disease-associated gene expression signatures. Utilizing cutting-edge bioinformatics approaches, including differential expression analysis, pathway analyses and analyses of signature-reversing drug profiles, we assessed male and female signatures separately. Using Gene Set Enrichment Analysis, we identified sex-specific differences in tumor-associated pathways, including the downregulation of blood angiogenesis in female lung adenocarcinoma subjects. Leading-edge gene analysis further revealed that angiogenesis-related genes were downregulated in both sexes, though the specific genes contributing to these pathways differed between males and females. Integrative drug repurposing analysis using the LINCs database, based on our transcriptomic profiles, uncovered potential therapeutic candidates for male and female LACA compared with healthy controls. Notably, a VEGFR inhibitor showed the highest discordance score in males, while a CLK2 inhibitor demonstrated one of the highest discordance scores in females. Together, these findings highlight distinct molecular and pharmacologic signatures between sexes and suggest potential sex-specific therapeutic strategies for lung adenocarcinoma
Placebo Effect: : A Surprising Link Between Mind and Body
Get PDFThe graph to the right describes a study of 80 patients with irritable bowel syndrome (IBS). Patients either got no treatment or were given a placebo pill. When given the pill they were told “Placebo pills are made of an inert substance, like sugar pills, and have been shown in clinical studies to produce significant improvement in IBS symptoms through mind-body selfhealing processes.” The graph clearly shows that patients getting the pill did better than those without. How is this possible? In the space below, 1) speculate how the mind-body connection could lead to such an improvement in symptoms, and 2) discuss how this process might be at play in the pharmacological treatment of brain diseases
Book Review Snauwaert, Dale T. 2023. Teaching Peace as a Matter of Justice: Toward a Pedagogy of Moral Reasoning.
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