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Improving the Writing Process and Making it Accessible to All
Get PDFWe live in a time where writing is ever-present in our world. Communication often happens in the form of writing and the majority of jobs require the skill of writing. The problem at hand is that not everyone has equal access to formal writing. In the history of education, writing has been taught as a corrective process, in which some students are “called out” for writing and speaking improperly. Most often these students are those who speak a stereotyped language, such as African American Vernacular. The corrective method creates further roadblocks for students to grow in their writing. The solution to this problem is the teaching of code-switching, in which students learn to “flip” from the informal to the formal
Midostaurin in Advanced Systemic Mastocytosis: A Systematic Review and Meta-analysis
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Cardioprotective Effects of Paraoxanase 3 in a Dahl Salt-Sensitive Rat Model of Chronic Kidney Disease
Get PDFObjective: Paraoxanases (Pon) are hydrolytic enzymes with three distinct isoforms. Decreased circulating Pon activity is associated with increased oxidant stress and adverse clinical outcomes in the setting of chronic kidney disease (CKD), yet the mechanism of action is unknown. We tested the hypothesis that Pon-3 is cardioprotective in a Dahl salt-sensitive model of hypertensive renal disease.
Methods: Ten week old, age-matched, Dahl salt-sensitive wildtype and Pon3 mutant male and female rats were maintained on eight percent high salt diets for eight weeks to initiate the salt-sensitive hypertensive renal disease characteristic of this model. After eight weeks, animals were euthanized and hearts were processed for histology. Echocardiography was performed to measure left ventricular function.
Results: By 8 weeks, mortality was observed in 18.2% of male SS-Pon3 KO rats on high salt; no mortality was observed in male SS male rats on high salt. In female rats, by 8 weeks 100% mortality was observed in SS-Pon3 KO rats on high salt diet while no mortality was observed in SS rats on high salt. High salt fed SS-Pon3 KO male rats that survived the echocardiography study demonstrated significantly decreased left ventricular end-systolic diameter and end-diastolic diameter, as well as significant increases in left ventricular relative wall thickness compared to age matched SS rats. Furthermore, SS-Pon3 KO rats demonstrated significantly increased heart-weight-to-body-weight ratio compared to age matched SS rats.
Conclusion: These findings suggest a cardioprotective role for PON-3 in the setting of salt-sensitive hypertensive renal disease
Harmful Algal Bloom Toxin Microcystin-LR Induces Macrophage Inflammation of Lung Tissues
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Exposure to Nanoplastics Induces an Inflammatory Response in Healthy and Type 2 Diabetic Primary Human Proximal Tubular Epithelial Cells
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Cyanotoxin Degrading Lake Bacteria Significantly Alleviate Microcystin-LR Induced Hepatotoxicity in Both In Vitro and In Vivo Models
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Severe Transaminitis in Allopurinol-Induced DILI presenting as DRESS Syndrome
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Analysis of Demographic and Staging Characteristics in Patients with Colorectal Cancer Using the SEER Registry
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Bilateral Accessory (Aberrant) Renal Arteries Associated With Uncontrolled Hypertension—Role of Renin-Angiotensin-Aldosterone Antagonist Drugs for Treatment Goal: : A Case Report
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Lithium-Induced Nephrogenic Diabetes Insipidus Self-Treated With Beer Potomania and Masquerading as Shock: : A Case Report
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