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    “adapt a large part of the institution to the Navy’s special needs”: The Navy Japanese Language

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    The onset of World War II drove the American government to seek support from universities across the nation to educate officers in the service in the language and customs of Japan. The University of Colorado Boulder played a significant role in hosting the U.S. Navy Japanese Language School from 1942 to 1946, and in training officers in the Japanese language. Many of the school’s graduates contributed significantly to the war efforts. This article explores the origins and evolution of the Japanese Language School at CU Boulder, providing a historical overview of the factors behind the school’s formation and the actions of its organizer Commander Albert E. Hindmarsh. Rooted in primary and secondary sources, including those from the University of Colorado Boulder libraries archives, the article traces the school’s establishment in the context of the strained relations between the U.S. and Japan, and discusses the invaluable role of its graduates to the war effort. In addition to teaching the Japanese language, the school and its teachers played a critical role in fostering positive relationships with the locals and addressing stereotypes. Graduates, both men and women, forged careers in diverse fields, becoming ambassadors for Japanese culture and language. The legacy of the Boulder school lives on in the various Japanese language programs existing across the country and in the personal transformations of those involved

    The Myth Behind the Mask: Blue Crew Secret Spirit Society at The University of Toledo - Recollections of a Founder

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    This article traces the history of the origins and evolution of Blue Crew, a secret spirit society at The University of Toledo (UToledo), through the recollections of one of the organization’s co-founders. Secret societies have existed on U.S. college campuses since 1750; however, Blue Crew’s unique characteristics and dedication to enhancing school spirit set it apart from other institutions’ secret societies. Founded in 2000, Blue Crew consists of 10 student members whose identities are hidden behind masks, wigs, and overalls. This secret society is devoted to building community and improving the campus culture by promoting university traditions. This article provides a rare glimpse at the organization’s beginnings and its positive influence on campus. The co-founder’s firsthand account pairs with archival resources to detail the creation, development, and unique characteristics of Blue Crew, including its purpose, name origins, hidden identities, distinct uniforms, “demasking” process, and challenges experienced throughout the years. Today, Blue Crew is a thriving society with over 130 total initiated members, an alumni association, and an endowment fund that financially supports its members and activities

    The Use of Ibrutinib in Extranodal Marginal Zone Lymphoma of the Ocular Adnexa with Multifocal Disease that is Refractory to Rituximab

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    Tumors of the ocular adnexa been well documented. The most common ocular adnexal lymphoma is extranodalmarginal zone B-cell lymphoma (EMZL), with about a quarter of those occurring in the conjunctiva. We present acase with a patient suspected ocular EMZL, confirmed with biopsy. Positron emission tomography (PET) scan wasperformed to evaluate for distal lesions and the patient was found to have multiple hypermetabolic lesionsthroughout the body. Treatment with rituximab was initiated, and after four weekly treatments, subsequent PETscan showed that the original hypermetabolic lesions remained and new lesions appeared. Rituximab was stoppedand ibrutinib started. After eight months of ibrutinib treatment, PET scan showed that the original hypermetaboliclesions had disappeared. 19 months from initiation of treatment, a new hilar lesion was found. This progressedinto bilateral hilar and mediastinal lymphadenopathy, which was seen on PET scan performed 29 months intotreatment. These findings remained stable 35 months post-initiation of treatment. The use of ibrutinib in thispatient that initially presented with a lesion in the conjunctiva resulted in an initial resolution of the originalsystemic hypermetabolic regions on PET scan. While more studies are needed on ibrutinib in the treatment ofocular EMZL, physicians should be aware of the presentation of this disease and the range of treatment modalities

    Probiotic Protects Kidneys Exposed to Microcystin-LR

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    Cyanobacterial Harmful Algal Blooms (CyanoHABs) occur when colonies of photosynthetic bacteria called cyanobacteria grow out of control, usually in warm, nutrient-rich, slow-moving waters. They are becoming increasingly prevalent around the world and release harmful toxins called cyanotoxins into bodies of water, which negatively affect human and ecological health. One such cyanotoxin is microcystin, with microcystin-leucine arginine (MC-LR) being the most widespread. Exposure to MC-LR inhibits serine and threonine protein phosphatase 1 and 2A in humans, causing a myriad of health problems. Fortunately, certain naturally occurring bacteria may be able to degrade MC-LR and reverse its effects. Mice were separated into five experimental groups based on three types of pre-treatments (control drinking water/vehicle, probiotic-supplemented drinking water, and heat-inactivated probiotic-supplemented drinking water) as well as two types of exposures (microcystin-LR and water/vehicle). RNA was extracted from kidneys for sequencing because MC-LR exacerbates kidney disease. Gene expression data were analyzed with 3 Pod Reports, an R package that produces a three-part report consisting of Gene Set Enrichment Analysis (GSEA), EnrichR, and integrative LINCS (iLINCS). MC-LR exposure was associated with upregulated cellular respiration and metabolism pathways and downregulated transcription pathways. Probiotic pre-treatment combined with MC-LR exposure was associated with upregulated lipoprotein particle pathways and downregulated respiration and ribosome pathways. Overall, the probiotic mixture corrected the transcriptional profile resulting from MC-LR exposure. Future high yield pathways that could be targeted for therapeutic benefit include VEGFR inhibitors and increased expression of renal kidney indicator genes such as EGFR

    Teaching Reasoning within Mathematics to Students with Severe to Profound Needs

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    Teaching reasoning within mathematics to students, specifically students with severe to profound special needs; requires student adaptive pedagogy, the use of discourse, and a focus on increasing motivation. This manuscript will explore some methods to promote and encourage discourse within mathematics, with a focus on how to do so in a practical and meaningful way for students with severe to profound special needs. All of this must be done by considering the individual needs of each student to increase intrinsic motivation which will help promote both generalization and maintenance of the skills learned.

    "In Great Degree of Spirit": Higher Education Studies at the University of Toledo

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    The University of Toledo’s Higher Education program and its Russel Center for the Study of Higher Education host the SHHE Journal. This first article provides a historical account of their origins and growth. The beginnings of higher education studies at the University of Toledo marks a significant milestone in the institution’s history. Introduced in 1960 at the doctoral level, the Higher Education program was amongst the pioneers of doctoral education at the municipal Toledo University. Its faculty awarded some of the first doctoral degrees at the university and established the first interdisciplinary research center on higher education studies in the state of Ohio. Drawing on archival resources and secondary research, this article examines the broader context of doctoral education in the United States and Ohio, the visionary leadership of the education faculty who championed the cause of graduate education, and the expansion of the program through its own department and research center. Despite many challenges, the Higher Education program and its research center thrived and evolved over the decades. Today, the program boasts more than 650 graduates while its alumni serve institutions of higher education nationwide

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