University of Toledo Open Journal System
Not a member yet
895 research outputs found
Sort by
Developmental pyrethroid exposure disrupts molecular pathways for circadian rhythms and synaptic plasticity in mouse brain.
Get PDF
Evaluating Attitudes and Educational Gaps in Transgender Healthcare Among Healthcare Professionals at a University Medical Center
Get PDFRare Case of Metronidazole-Induced Encephalopathy in a Multiple Transplant Recipient: Clinical and Radiological Insights
Get PDF
Unraveling the Gut: A Case of Adult-Onset Avoidant Restrictive Food Intake Disorder Related To Chronic GI Issues
Get PDFPathway enrichment and FDA-approved drug repurposing analysis for the treatment of CTNNB1 Syndrome modeled in an SH-SY5Y cell line
Get PDF
World-Centred Peace Education: Toward a Framework for Socio-Eco Peace in Times of Systemic Crisis
Get PDFThis article develops a novel framework for world-centred peace education in response to today’s interconnected social and ecological crises. It critiques anthropocentric models and the War System, arguing for a paradigm shift that centres relationality and the interdependence of people and planet. The framework is grounded in the concept of socio-eco peace—a vision of mutual flourishing—and integrates a guiding purpose, a relational worldview, theoretical influences, and five interrelated domains: inner, outer, context, pluralism, and process. These domains support peace education that is holistic, inclusive, and responsive to place, time, and community. The article explores how the framework can inform the design, facilitation, and evaluation of peace education across diverse settings, and concludes with implications for theory, policy, practice, and future research
Tracking Neural Deterioration in proNGF-Overexpressing Mice: Hippocampal Serotonergic Dysfunction and Synaptic Loss Drive Neurodegeneration
Get PDFProNGF, the precursor protein of mature nerve growth factor (NGF), plays a complex role in neural signaling and has been implicated in neurodegeneration through its apoptotic signaling with the p75NTR receptor. For example, in Alzheimer's disease increased levels of proNGF are associated with cholinergic neuron loss and excitatory/inhibitory imbalance. This study deploys cutting edge a bioinformatic analyses of RNAseq data from TgproNGF#3 mice models that express furin-resistant proNGF. The TgproNGF#3 mouse mimics the pathological accumulation of the precursor NGF protein observed in these diseased brains. Our analysis revealed that proNGF accumulation in the hippocampus and entorhinal regions leads to early downregulation of genes critical for neuronal communication, such as pion and KCNAB2, and later to the upregulation of stress-related and signaling genes, including Neurod1, Neurod2, and Gnai1. These shifts in gene regulation suggest that while the brain attempts to counteract the excess in proNGF, its delay and inefficacy may contribute to early-stage Alzheimer's disease processes