Open Access Publications (Univ. de Genève)
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New chemistry in unusual bacteria displays drug-like activity
No full textGenetics revealed a rare soil bacteria may produce bioactive molecules. We discovered two new dimer molecules produced by this organism: one of which had an unusual heterodimer structure. Our assays showed these dimers had increased bioactivity against cultured cancer cells. The heterodimer’s activity was very strong, suggesting that natural-made heterodimeric molecules can be used as templates for new pharmaceuticals.
Vascular Health: The Power of Implantable Wireless Electronics
No full textThe continuous monitoring of vascular health achievable by implantable electronics can offer improved disease diagnosis and treatments. We developed a wireless nanomembrane system consisting of a smart stent and soft sensors to enable simultaneous monitoring of blood pressure, blood flow, and pulse rate
The RAINmakers: how receptors orchestrate specific cell functions
No full textThe exact interplay between receptors and their downstream signaling influences essentially all physiological functions. But how can a cell discriminate between hundreds of different receptors that share the same downstream signaling transducers? We find receptor-associated independent signaling nanodomains (RAINs) around single receptors which can specifically switch signaling cascades on or off
InSight seismic waveform data reveal more marsquakes
No full textAnalyzing seismic waveforms recorded by the InSight mission seismometer, we discovered and documented 47 marsquakes in the Cerberus Fossae region of Mars. Their repetitive nature at all times of the Martian day tells a story of their likely volcanic origin and of a mobile Martian mantle. Mars harbours a liquid core, and it remains to be understood why the Martian geodynamic field ceased to exist
Can dark matter interact with itself?
No full textDark matter, the “glue” that holds our Universe bound, remains a mystery. A key question to understand its nature is whether dark matter particles can interact with each other in more ways than only through gravity. Using X-ray data of galaxy clusters, scientists revealed whether self-interacting dark matter could be the answer to one of the unsolved problems in cosmology
Edible Microparticles: A Revolutionary Solution to Global Vitamin A Deficiency
No full textVitamin A deficiency impacts millions globally. Directly adding it to foods is problematic due to its sensitivity to light and heat. We\u27ve created an edible microparticle ensuring safe vitamin A delivery. These microparticles are stable and offer high absorption rates, presenting a groundbreaking solution to combat vitamin A deficiency and degradation globally
The fate of a century-old partnership between humans and dolphins
No full textAligning human interests and wildlife protection requires a deep understanding of human-wildlife interactions. Behavioral tracking and demographic surveys show that foraging synchrony is key to generate short- and long-term benefits for human fishers and wild dolphins. We used simulations to describe the conditions under which this cooperation can turn into another human-wildlife conflict
OER as a certain solution for uncertain times: A reflection on the initiatives undertaken in Morocco during the covid-19 period
Get PDFThe COVID-19 pandemic has generated a high degree of uncertainty about the state of education. During this critical period, the entire educational landscape was in need of relevant educational resources that could be shared between and within educational networks. In this regard, open educational resources (OER) and open educational practices (OEP) have played an important role in ensuring educational continuity. Research has shown that open approaches will help make the higher education ecosystem more resilient to future crises and the sustainability of this ecosystem can be fueled by the widespread use of OER and OEP. However, additional work is still needed in this area either at the personal, organizational, or institutional level. In this paper, we discuss the potential of OER and OEP, as certain solutions, to improve quality and widen access in uncertain times such as the COVID-19 crisis, we also present an analysis from an OER perspective of the initiatives undertaken at the Cadi Ayyad University (UCA) in Morocco as example in order to assess the extent to which they can be considered as OER. On the other hand, we highlight the benefits of this experience, as well as identify the barriers that hinder the adoption of open solutions in order to propose some recommendations and guidelines to foster the implementation of these solutions
Ressources Educatives Libres et éducation ouverte : l’écosystème RELIEFH pour l’égalité femme-homme
Get PDFIn our modern and globalized society, open educational resources (OER) are taking advantage of the digital revolution and networking to become one of the main propellants to free knowledge access movement that is covering a wide range of domains through multiple services and products. As parts of a worldwide educational ecosystem, OER and open education can provide wide access to information and education resources despite the extreme inequalities reported in digital empowerment and significant technological barriers to digital participation mainly in developing countries. In this article, we argue that while technological barriers must certainly be removed, the potential of OER and open education in the “Quality education” (the fourth of UN Sustainable Development Goals), can only be fully optimized when societal and economic inducements would also be guaranteed to girls and women to elevate their intellectual and professional status. We therefore focus on OER as a catalyst for gender equality and quality education in the Francophone context. Our main objective is to present a French-speaking OER editorial policy led by the Institut de la Francophonie pour l\u27Ingénierie de la Connaissance et la Formation à distance (IFEF) around its OER portal RELIEFH. Although OER in the French-speaking countries are recent and their tools and products are limited, IFEF is proposing a prominent educational service based on an open and collaborative editorial OER policy.Va être ajout
Trouver de l’argent et de l’or pour Masaharta: Un ostracon de la Vallée des rois de la 21e dynastie
Get PDFThis paper presents a hieroglyphic transcription and annotated translation of a hieratic text inscribed on an ostracon recently found in the Valley of the Kings by an Egyptian mission (O. VoK 2022.13). The text consists of a prayer to Amun-Ra in which the Scribe of the Tomb, probably a grandson of Butehamun (i), asks the god to help him locate silver and gold that he can bring to the High Priest of Amun Masaharta, thus attesting to the official plundering of the Valley of the Kings during the early 21st Dynasty. The text is dated to Year 24, adding six years to the attested period of Masaharta’s pontificate.Dans cette contribution, je propose une transcription hiéroglyphique ainsi qu’une traduction commentée d’un texte hiératique écrit sur un ostracon récemment découvert dans la Vallée des Rois par une mission égyptienne (O. VoK 2022.13). Il s’agit d’une prière à Amon-Rê dans laquelle le scribe de la Tombe, probablement un petit-fils de Boutéhamon (i), demande au dieu de l’aider à trouver un lieu rempli d’argent et d’or qu’il puisse apporter au Grand Prêtre d’Amon Masaharta, attestant d’un pillage d’État de la Vallée des Rois au début de la 21e dynastie. Le texte est daté d’un an 24, ce qui ajoute six années sûres au pontificat de Masaharta, jusqu’ici documenté jusqu’en l’an 18