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Analyzing the Inhibition Of Chemical Compounds On Collagenase in P. aeruginosa
Get PDFPseudomonas aeruginosa is an opportunistic pathogen that poses significant challenges in clinical treatment due to its production of collagenase. This bacterium can cause several infections including pneumonia, meningitis, septicemia, and a host of other diseases. Collagenase acts as a key virulence factor by breaking down collagen in the host’s extracellular matrix, allowing bacteria to invade tissues. This study hypothesized that the effects of cell secreted collagenase would be inhibited by metronidazole, vanillin, and silver nanoparticles to reduce the pathogenicity of Ps. aeruginosa related infections.https://ouscholars.oakwood.edu/student-posters/1109/thumbnail.jp
Analysis of Cys294Arg Mutation in CS1 Associated with Periodontal Ehlers-Danlos Syndrome & Collagen Degradation
Get PDFC1s enzyme plays a crucial role in the immune system so that the body can fight infection and repair damaged tissues. However, if it is not working properly, it will do more harm than good. This is shown in the case of periodontal Ehlers-Danlos syndrome (pEDS), a rare genetic disorder whereby C1s breaks down collagen I, a protein that gives structure and strength to connective tissues. Severe gum disease, loose teeth and premature teeth is a result of this. The purpose of this study is to identify and analyze the pathogenicity of C1s mutations and association in pEDS.https://ouscholars.oakwood.edu/student-posters/1103/thumbnail.jp
Analysis of CD36 variants associated with Heart Disease
Get PDFCardiovascular/Heart Disease (CVD) is commonly characterized when coronary arteries struggle to supply the heart with enough blood, oxygen, and nutrients. Some symptoms include chest pain, shortness of breath, pain in the neck, numbness, weakness, or coldness in the arms or legs, dizziness or fainting, and fatigue or exhaustion. Cardiovascular disease affects an estimated 47-54% of Black adults in America (Cleveland Clinic). The purpose of this study is to identify and assess the pathogenicity of the CD36 variants associated with cardiovascular disease.https://ouscholars.oakwood.edu/student-posters/1097/thumbnail.jp
Analysis of KCNJ2 Variants Associated with Wolff-Parkinson-White Syndrome
Get PDFWolff-Parkinson-White (WPW) syndrome is a cardiac disorder characterized by an accessory electrical pathway, leading to tachycardia and arrhythmias. It is diagnosed via electrocardiogram (ECG), showing a shortened PR interval and delta wave. WPW is typically managed with medications, catheter ablation, or surgery. Although primarily caused by anatomical anomalies, emerging research suggests genetic factors, including ion channel mutations, may contribute to the condition. The KCNJ2 gene encodes an inward-rectifier potassium channel critical for cardiac excitability. Mutations in KCNJ2 are linked to Andersen-Tawil syndrome, a disorder featuring arrhythmias and muscle weakness, raising questions about its role in WPW. This study investigates whether KCNJ2 variants influence WPW syndrome, potentially affecting its severity.https://ouscholars.oakwood.edu/student-posters/1096/thumbnail.jp
Genetic Insights into Glaucoma: The Impact of TKB1 Mutations on Glaucoma
Get PDFGlaucoma is a chronic eye disease that can lead to blindness by damaging the optic nerve. It impairs the eye’s ability to drain fluid, resulting in increased eye pressure, which subsequently causes damage to the optic nerve in the back of the eye. The purpose of this study is to identify and evaluate the pathogenicity of TBK1 diversity associated with Glaucoma.https://ouscholars.oakwood.edu/student-posters/1094/thumbnail.jp
An Analysis of FTL variants associated with Cataracts Disease
Get PDFCataract is an eye disease that clouds the eye\u27s natural lens, which is used to focus light on the retina. This eye disease causes symptoms such as blurry vision, double vision, sensitivity to light, and difficulty seeing at night. Cataracts are tied to the gene called Ferritin Light Chain (FLT), which is found in both prokaryotes and eukaryotes and plays a role in encoding the light subunits of the ferritin protein. The purpose of this research study was to identify the Ferritin Light Chain mutations that cause cataracts.https://ouscholars.oakwood.edu/student-posters/1091/thumbnail.jp
An Analysis of SIM1 Variants Associated with Diabetes
Get PDFDiabetes is a chronic condition that affects the body\u27s use of glucose. This is due to insufficient production of insulin or the inability to effectively utilize insulin. There are two types of chronic diabetes, type 1 and type 2. These types are irreversible but can be managed with the right treatments. Prediabetes and gestational diabetes can be reversible. Whether they go away on their own or can be prevented from transitioning to something more serious. The purpose of this research study is to analyze the pathogenicity of the mutation SIM1 gene and its association with diabetes.https://ouscholars.oakwood.edu/student-posters/1105/thumbnail.jp
Bioinformatics Analysis of the MBL2 Missense Variants Associated with Cystic fibrosis
Get PDFCystic fibrosis (CF) is an autosomal recessive disease commonly recognized by thick mucus and loud coughs. The manifestation of these symptoms is due to the inability of chloride ions to diffuse out of the cell. Thus, preventing osmosis resulting in a thick mucus on the lung’s surface. Those who suffer from this disease have difficulty breathing and require a modulator with a vest to increase gas exchange in the lungs. Moreover, the disease can result in much pain due to coughs, which destroys ciliated epithelial cells. Patients who have cystic fibrosis can suffer from pneumonia and other bronchial infections. They also experience difficulties with secretions out of exocrine glands. The low-frequency gene, Mannose Binding Lectin-2 (MBL2) associated with cystic fibrosis was analyzed for this study. This gene encodes for a protein that plays an integral role in the innate immune system. It binds to the mannose and N-acetylglucosamine found on the surface of pathogens. It then removes the pathogen by signaling the lectin complement system and phagocytic cells. The purpose of this study was to observe the missense mutations within this gene. Computational tools were used to view the mutated variants, the 3-D modelling, and conserved domains. The simple ClinVar database identified variants within this gene. Polyhen2 was used to analyze the pathogenicity of Gly54Asp and Pro101Leu. The computational tool predicted Gly54Asp as probably damaging” with a 1.00 sensitivity score. The Pro101Leu swap was deemed to be “benign” with a sensitivity score of 0.043. Upon further analysis, the SIFT tool predicted the substitution to affect the protein. The second variant, Pro101Leu was predicted to be tolerated . The SWISS modelling further identified the physical changes in the protein structure. Analysis of mutations within this gene can prevent other infections; ultimately, preventing the exhibition of cystic fibrosis.https://ouscholars.oakwood.edu/student-posters/1075/thumbnail.jp
Study of MYL3 Mutation Variants and Their Association with Cardiac Amyloidosis
Get PDFCardiac Amyloidosis is a rare serious, pathological, clinical progressive disease that is caused by the buildup of amyloid fibrils deposited at the cardiac level. The excess amyloid fibrils deposited in the myocardium leads to this critical condition. Cardiac amyloidosis is best treated when diagnosed in its initial stages. The purpose of this study was to identify and assess the clinical significance and pathogenicity of the Myosin light chain 3 (MYL3) its variants, and the potential link to cardiac amyloidosis. For this study, Simple ClinVar was utilized to identify MYL3 as one of the genes correlated with Cardiac Amyloidosis and variants. The three MYL3 missense variants identified were the Met149Val, which is suggested potentially pathogenic variant, the Arg94His, which is a suggested possibly pathogenic/likely pathogenic variant, and Arg31His, which is a suggested uncertain/unconflicting variant. According to ClinVar, MYL3 is expressed only in the heart. PolyPhen-2 and SIFT were used to further evaluate the pathogenicity of the three variants.https://ouscholars.oakwood.edu/student-posters/1069/thumbnail.jp
Improving Biocompatibility and Structural Integrity of Decellularized Biomaterials
Get PDFTissue engineering is a revolutionary approach to regenerative medicine. Within the field of tissue engineering, biomaterials such as the great saphenous vein or synthetic materials such as PET, are used in tissue generation for grafts and wound healing in many other uses. This is promising and has the potential to save many lives, but many glaring issues prevent the use of these scaffolds in a clinical setting. Some of these include body rejection, lack of hemocompatibility, and weak structural integrity.https://ouscholars.oakwood.edu/student-posters/1061/thumbnail.jp