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Using Secreted Biomarkers in the Development of the Detection of Advanced Cancer Screening System
Get PDFAn estimated 20 million people globally develop cancer every year. Furthermore, over 9.7 million people die from cancer. The best prognosis of cancer occurs when detected early. Cancer, in its early stages, usually does not display clinical symptoms and is usually not detectable by symptoms and is diagnosed later. The goal of the D.A.C.S. is to provide a screen that can detect cancer. It is hypothesized that developing a cancer detection system/technology, named D.A.C.S. (Detection of Advanced Cancer Screening) system, can help with early cancer detection, while still being affordable for the general public.https://ouscholars.oakwood.edu/student-posters/1063/thumbnail.jp
Silver Nanoparticles and Natural Compounds can Modulate Proteolytic Activities of Escherichia coli
Get PDFEscherichia coli (E. coli) is a gram-negative, facultative anaerobic bacterium that naturally resides in the human gastrointestinal tract as a commensal microorganism. While non-pathogenic strains contribute to digestion and vitamin production, certain pathogenic strains can cause a wide range of diseases, from mild gastrointestinal discomfort to severe illness. A key factor in its pathogenicity is the production of protease enzymes that break down proteins which play a crucial role in bacterial survival and virulence. This study aimed to investigate the effectiveness of different antibacterial compounds in inhibiting the function of both secreted and cell-associated E. coli protease activity.https://ouscholars.oakwood.edu/student-posters/1059/thumbnail.jp
An analysis of VHL and its relation to Leukemia
Get PDFLeukemia is a special type of cancer caused by the overproduction of abnormal white blood cells. It is the cancer of blood-forming tissues such as the bone marrow, making it difficult to fight against foreign agents. Leukemia is the 10th most common cancer accounting for 3.1% of all new cancer cases and 3.9% of all cancer deaths (National Institute of Health). The purpose of this study is to analyze the potential genetic mutations or variants associated with the leukemia phenotype.https://ouscholars.oakwood.edu/student-posters/1123/thumbnail.jp
Impact of MSX1 and IRF6 Gene Variants on Orofacial Cleft and Facial Development
Get PDFA cleft lip or palate is a congenital anomaly that occurs when a baby\u27s mouth doesn’t form properly during pregnancy. It happens when the tissues that shape the upper lip or roof of the mouth fail to join during development. It is among the most common birth defects associated with genetic conditions or syndromes. Orofacial cleft can be caused by a combination of genes and other factors like the mother\u27s exposure to environmental things, diet, and medications during pregnancy. Examining the genes involved and making connections that provide insight into the improper formations of the maxillary tissues during fetal stages is crucial. This study used Simple Clinvar, Uniprot, Polyphen 2, SIFT, and SWISS Modeling to identify and analyze mutations.https://ouscholars.oakwood.edu/student-posters/1108/thumbnail.jp
An Analysis of Androgen Receptor (AR) Variants in Breast Cancer
Get PDFThe androgen receptor (AR) is a steroid-hormone activated transcription factor that regulates gene expression in response to testosterone and dihydrotestosterone (DHT). While AR has been extensively studied in prostate cancer, emerging research suggests its role in breast cancer, particularly in estrogen receptor-positive (ER-positive) and triple-negative breast cancer (TNBC). This study investigates AR variants associated with breast cancer, assessing their pathogenicity and potential impact on prognosis and treatment.https://ouscholars.oakwood.edu/student-posters/1070/thumbnail.jp
The Analysis of the COMT gene contribution to Schizophrenia
Get PDFSchizophrenia is a disease that is a result of an imbalance of the neurotransmitter dopamine in the brain. Schizophrenia is a polygenic disorder associated with many genes. The cause of schizophrenia is still unknown, but a variety of genes have been linked to the progression of the disease. These neurotransmitters are chemicals that allow the brain to receive and send messages between neurons. The purpose of this study is to be able to identify and analyze the COMT variants pathogenicity potential and the possible association with the schizophrenia phenotype.https://ouscholars.oakwood.edu/student-posters/1101/thumbnail.jp
Silver Nanoparticles and Vanillin Can Inhibit Collagenase Activities of Serratia marcescens
Get PDFSerratia marcescens is a gram-negative, disease-causing agent that belongs to the Enterobacteriaceae family. This rod-shaped microbe causes many infectious diseases such as urinary and respiratory infections, wound infections, and peritonitis, which can result in fatal bacteremia. Protease is a virulence factor of S. marcescens that enhances its pathogenicity by breaking down proteins via cleavage of peptide bonds. The purpose of this research is to identify testing agents that reduce the protease mediated pathogenicity of S. marcescenshttps://ouscholars.oakwood.edu/student-posters/1058/thumbnail.jp
The Duality of the BARD1 Gene
Get PDFBreast cancer is the 2nd most diagnosed cancer in women in the United States (Mayo Clinic). Cancer is the overproduction of cells. In other words, cancer-infected cells continue to grow and may cause large growths called tumors. Although there have been innumerable strides in breast cancer research, the exact cause for breast cancer is not yet known (Mayo Clinic). It is believed that factors such as family history of the disease, early menstruation age, and obesity can increase an individual’s chances of having breast cancer. One of the well-known genes associated with breast cancer is BRCA1. A much less researched gene associated with breast cancer is BARD1 (BRCA1 associated ring domain 1). ClinVar identified the BARD1 gene to be connected to breast cancer, and over 1000 missense variants. Most of the variants had uncertain/conflicting clinical significance. ClinVar also identified the single nucleotide variants Pro7Ser and Cys71Tyr as missense mutations linked to BARD1. Pro7Ser had an uncertain/conflicting clinical significance and Cys71Tyr was classified as pathogenic. SIFT and PolyPhen2, bioinformatics software, determined that the Cys71Tyr mutation is probably damaging, and the Pro7Ser mutation is benign. The BARD1 gene’s FASTA sequence was placed into the SWISS-Model software to create a 3D protein model. These findings further support previous studies on the correlation between familial breast cancer and the BARD1 gene.https://ouscholars.oakwood.edu/student-posters/1078/thumbnail.jp
Mutations in the PMS1 Gene Associating with Ovarian Cancer
Get PDFThe female reproductive system contains two ovaries on each side of the uterus, producing eggs and hormones such as estrogen and progesterone. Ovarian cancer occurs when abnormal cells in the ovaries grow and divide uncontrollably, destroying healthy body tissue. Common symptoms of ovarian cancer include weight loss, fatigue, discomfort in the pelvic area, or changes in bowel habits. The goal of this research is to understand and identify the pathogenicity of the PMS1 gene in ovarian cancer and factors associated specifically with the mutation.https://ouscholars.oakwood.edu/student-posters/1065/thumbnail.jp
An Analysis of DGUOK Variants Associated with Mitochondrial DNA Depletion Syndrome
Get PDFMitochondrial DNA Depletion Syndrome(MDDS) is a clinically heterogeneous group of autosomal recessive mitochondrial disorders that reduces the number of mitochondrial DNA (mtDNA) in the affected cells. This disease is characterized by the disruption of hepatocytes, skeletal muscle, and cerebral function. This study\u27s purpose is to identify and assess the pathogenicity of DGUOK variants associated with MDDS.https://ouscholars.oakwood.edu/student-posters/1084/thumbnail.jp