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A tale of three domes: the un-realized cupola of St Ignatius of Loyola in Roma
Get PDFThe church of St Ignatius of Loyola in Rome, together with the Church of the Gesù, represents the most significant artistic contribution of the Jesuits in the Eternal City. Incorporated in the broader context of the Roman College, and built between 1626 and 1650 following a project by Padre (Father) Orazio Grassi S.J., it is the only one of the great Roman churches without a dome. The projects for the helioscopic dome by Orazio Grassi, the Cortonesque dome by Armando Brasini and the perspective dome by Andrea Pozzo represent the difficult attempt to create a perfectly rational layout for Rome, an ideal scientific and theological city. These projects tell the story of three different ways of conceiving architectural space affecting the city: political manifesto, imaginative introspection and colossal scenography. This paper describes the history of an “impossible” dome, analysing the historical evolution of the project and its three potential authors, three magnificent and idealist designers
Why are some inhibitory tasks easy for preschool children when most are difficult? Testing two hypotheses.
No full textUnderstanding the processes that create inhibitory demands is central to understanding the role of inhibitory control in all aspects of development. The processes that create inhibitory demands on most developmental tasks seem clear and well understood. However, there is one inhibitory task that appears substantially easier than the others: the Reverse Categorization task, in which children are asked to "reverse sort" items (e.g., put large items in a small box and put small items in a large box). This finding is both surprising and problematic because it cannot be explained by any existing account of inhibitory development. Four experiments with 3- and 4-year-olds sought to explain why the Reverse Categorization task is easy. Two experiments (N = 64) investigated the hypothesis that children conceptualize the task in a way that reduces its inhibitory demands; and two experiments (N = 56) tested the hypothesis that the task is easier because children sort items slowly. The data indicate that children spontaneously respond more slowly on the Reverse Categorization task than on other inhibitory tasks and that this slowing reduces the task's cognitive demands. The way in which slowed responding works, and its relation to other inhibition-reducing interventions, is discussed. [Abstract copyright: Crown Copyright © 2022. Published by Elsevier Inc. All rights reserved.
Interventions for mental health, cognition, and psychological wellbeing in long COVID: a systematic review of registered trials.
Get PDFBackground
Among patients diagnosed with COVID-19, a substantial proportion are experiencing ongoing symptoms for months after infection, known as ‘long COVID’. Long COVID is associated with a wide range of physical and neuropsychological symptoms, including impacts on mental health, cognition, and psychological wellbeing. However, intervention research is only beginning to emerge. This systematic review synthesizes currently registered trials examining interventions for mental health, cognition, and psychological wellbeing in patients with long COVID.
Methods
Standard systematic review guidelines were followed. Trials registered in two large trial registries in 2020 to May 2022 were reviewed. Included studies were narratively synthesized by type of intervention and a risk-of-bias assessment was conducted.
Results
Forty-two registered trials were included, with a total target sample size of 5814 participants. These include 11 psychological interventions, five pharmacological and other medical interventions, and five evaluating herbal, nutritional, or natural supplement interventions. An additional nine trials are examining cognitive and neurorehabilitation interventions and 12 are examining physiotherapy or physical rehabilitation. Most trials are randomized, but many are feasibility trials; trials are evaluating a wide spectrum of outcomes.
Conclusions
While there is a newly emerging body of research testing interventions for mental health, cognition, and psychological wellbeing in long COVID, the breadth and scope of the research remains limited. It is urgently incumbent on researchers to expand upon the intervention research currently under way, in order to generate high-quality evidence on a wide range of candidate interventions for diverse long COVID patient populations
HIV and Schistosoma co-exposure leads to exacerbated pulmonary endothelial remodeling and dysfunction associated with altered Cytokine Landscape
Get PDFHIV and Schistosoma infections have been individually associated with pulmonary vascular disease. Co-infection with these pathogens is very common in tropical areas, with an estimate of six million people co-infected worldwide. However, the effects of HIV and Schistosoma co-exposure on the pulmonary vasculature and its impact on the development of pulmonary vascular disease are largely unknown. Here, we have approached these questions by using a non-infectious animal model based on lung embolization of eggs in HIV-1 transgenic (HIV) mice. Schistosome-exposed HIV mice but not wild-type (Wt) counterparts showed augmented pulmonary arterial pressure associated with markedly suppressed endothelial-dependent vasodilation, increased endothelial remodeling and vessel obliterations, formation of plexiform-like lesions and a higher degree of perivascular fibrosis. In contrast, medial wall muscularization was similarly increased in both types of mice. Moreover, HIV mice displayed an impaired immune response to parasite eggs in the lung, as suggested by decreased pulmonary leukocyte infiltration, small-sized granulomas, and augmented residual egg burden. Notably, vascular changes in co-exposed mice were associated with increased expression of proinflammatory and profibrotic cytokines, including IFN-γ and IL-17A in CD4 and γδ T cells and IL-13 in myeloid cells. Collectively, our study shows for the first time that combined pulmonary persistence of HIV proteins and Schistosoma eggs, as it may occur in co-infected people, alters the cytokine landscape and targets the vascular endothelium for aggravated pulmonary vascular pathology. Furthermore, it provides an experimental model for the understanding of pulmonary vascular disease associated with HIV and Schistosoma co-morbidity
Psychometric evaluation of the Thai version of the Self-Care of Coronary Heart Disease Inventory Version 3
Get PDFAbstract Aims Engaging in self-care is an important aspect of the prevention and management of coronary heart disease (CHD), the leading cause of premature death in Thailand. As no validated tool exists to measure self-care in Thai people with CHD, we translated and examined the psychometric properties of the Self-Care of Coronary Heart Disease Inventory Version 3 (SC-CHDI-V3) in a Thai population. Methods and results The SC-CHDI-V3 was translated into Thai using the standard forward and backward translation procedure for self-care instruments. A cross-sectional design was used to examine the psychometric properties of the Thai version of the SC-CHDI-V3 in 250 patients with confirmed CHD in a tertiary hospital in southern Thailand. Cronbach’s alpha and McDonald’s omega coefficients were used to assess internal consistency, and confirmatory factor analysis was performed to assess construct validity. The Thai version of the SC-CHDI-V3 demonstrated acceptable internal consistency (Cronbach’s alpha and McDonald’s omega coefficients of each scale ranged from 0.821 to 0.910). Reliability estimates were adequate for each scale (range 0.863–0.906). Confirmatory factor analysis supported the original factor structure of the instrument, with good fit indices for all three scales (comparative fit index = 0.996–1.000; root mean square error of approximation = <0.001–0.040). Conclusions The Thai version of the SC-CHDI-V3 appears to be a valid and reliable instrument for measuring engagement in self-care maintenance, self-care monitoring, and self-care management among Thai people with CHD
Reconfiguring the biomedical dominance of pain: time for alternative perspectives from health promotion?
No full textPersistent pain is a major health care challenge. Most approaches to tackle pain involve medical treatments to relieve pain once it has become a problem. There has been little research into the role of activities that promote health and wellbeing on pain. We argue that there needs to be more research on how people living with persistent pain can continue to flourish and function with good health. We suggest that there needs to be more attention given to health promotion and community-based approaches to tackle persistent pain and that more research is needed on cultural, environmental, economic, and social factors that influence pain
An eHealth intervention (ManGuard) to reduce cardiovascular disease risk in male taxi drivers: protocol for a feasibility randomised controlled trial
Get PDFAbstract: Background: Men are at higher risk then women of developing cardiovascular disease (CVD), and male taxi drivers are a particularly high-risk group because of their typically unhealthy behaviours, such as poor eating habits, smoking and sedentary lifestyle. However, only two studies of behavioural interventions targeting taxi drivers have been identified, one of which reported a high attrition rate. Therefore, an eHealth intervention co-designed by taxi drivers may prove more acceptable and effective. The aim of this study is to assess the feasibility an eHealth intervention (ManGuard) to reduce CVD risk in male taxi drivers. Methods: A randomised wait-list controlled trial will be conducted with a sample of 30 male taxi drivers to establish feasibility, including recruitment, engagement, and retention rates. Program usability and participant satisfaction will be assessed by a survey completed by all participants at 3 months after allocation. Additionally, an in-depth qualitative process evaluation to explore acceptability of the intervention will be conducted with a subset of participants by semi-structured telephone interviews. Preliminary efficacy of ManGuard for improving key CVD-related outcomes will be assessed, including biomarkers (total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, and total/HDL cholesterol ratio), blood pressure, anthropometry (body mass index, body fat percentage, and waist circumference), physical activity (accelerometery, and self-report) and psychosocial status (health-related quality of life, self-efficacy, and social support). Outcomes will be assessed at baseline, 7 weeks, and 3 months after group allocation. The wait-list control group will be offered access to the intervention at the completion of data collection. Discussion: eHealth interventions show potential for promoting behaviour change and reducing CVD risk in men, yet there remains a paucity of robust evidence pertaining to male taxi drivers, classified as a high-risk group. This study uses a randomised controlled trial to assess the feasibility of ManGuard for reducing CVD risk in male taxi drivers. It is envisaged that this study will inform a fully powered trial that will determine the effectiveness of eHealth interventions for this high risk and underserved population. Trial registration: This trial has been registered prospectively on the ISRCTN registry on 5 January 2022, registration number ISRCTN2969394
‘My story’: using a life story approach to build friendships between younger and older people to alleviate loneliness and social isolation.
No full textLoneliness and social isolation for older people remain a problem. Intergenerational befriending may be one solution that could help with loneliness and social isolation. ‘My Story’ is based on a life story approach aimed at facilitating friendship by providing a format for older and younger people to interact. An original pilot was undertaken to test the approach by bringing together older people identified as lonely by a voluntary sector provider and pairing these with a student volunteer. The students visited the older person over six weeks to discuss their life story and create an artefact based on the story of the older person. Three pairings were studied to explore the experiences of the older and younger person using ‘My Story’. The focus of the case studies was if a therapeutic alliance emerged which could lead to friendship. The research found that in the two of the pairings, ‘My Story’ helped to create mutual benefit and a therapeutic bond that could lead to friendship. As this was an exploratory and small pilot, more cases and further research is required to fully assess if ‘My Story’ is an effective approach to intergenerational befriendin
