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    Editorial Committee

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    電荷反転型脂質ナノ粒子のタンパク質製剤への応用

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    静岡県立大学博士 (生命薬科学)2024application/pdfdoctoral thesi

    編集委員会

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    奥付

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    目次

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    Seismicity Before and After the 2023 M7.7 and M7.5 Turkey Quakes

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    application/pdfA magnitude (M) 7.7 quake struck on 6 February 2023 in Turkey. Nine hours later, a M7.5 quake occurred near the initial M7.7 quake. We studied seismicity before and after these doublet quakes, integrating physics-based and statistical approaches. We first used the statistical Epidemic-Type Aftershock Sequence (ETAS) and the Bayesian Gutenberg–Richter b-value models to confirm previously reported seismicity transients (seismic activation and low b values) prior to the future M7.7 quake. We then showed that the low b-value area coincided with a high-slip area on the strand segment from which the M7.7 rupture started, a similar result to that obtained for the 2011 Tohoku megaquake case in Japan. We next used the physics-based Coulomb and statistical b-value models to find that the locations of the largest and second-largest events in the post-doublet-quake sequence were in relatively high-stress regions and became closer to failure as a result of the doublet quakes. We further used the ETAS model to show that this sequence is currently active but is decaying with time. The duration of the sequence was estimated at 2.7–5.5 years, which is longer than previously proposed (1–2.5 years). Our result was stable because it was based on quake data from about 600 days, six times longer than the study period used in a previous study.journal articl

    Effects of skipping breakfast, lunch or dinner on subsequent postprandial blood glucose levels among healthy young adults

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    application/pdfMeal skipping has become increasingly common in modern society due to changes in lifestyle. While the adverse effects of skipping breakfast on postprandial glucose levels have been well established, less is known about the impact of skipping lunch or dinner on these levels. The aim of this study is to determine the effect of skipping breakfast, lunch, and dinner consecutively on postprandial glucose levels in healthy subjects. Thirteen healthy young adults were enrolled and instructed to consume meals freely at designated times while maintaining detailed food intake records. Participants then followed a controlled protocol in which one of the three meals was skipped for two consecutive days in a specified order, with interstitial glucose continuously monitored. Skipping lunch on both days significantly increased postprandial glucose levels at the subsequent dinner by 1.6 mmol/L compared to when lunch was consumed and breakfast was skipped (p < 0.001). In contrast, skipping dinner or breakfast did not result in significant changes in postprandial glucose levels at the following meal. We thus observed skipping each of these three meals to have different effects on subsequent postprandial blood glucose levels in the healthy subjects. Most notably, skipping lunch leads to increased postprandial blood glucose levels at dinner.journal articl

    奥付

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    Pd触媒によるクロロアレーンとビフェニル-2-オールを用いるC‒Hアリール化及びトリベンゾオキセピンの一段階合成法の開発

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    静岡県立大学博士 (薬学)2024application/pdfdoctoral thesi

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