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Pyrroloindoline/Pyridoindoline Synthesis via C3-Dearomative Arylation/Cyclization of Tryptamine/Homotryptamine Derivatives Using Palladium–Dihydroxyterphenylphosphine Catalyst
Get PDFapplication/pdfA palladium–dihydroxyterphenylphosphine (DHTP) catalyst was successfully applied to the dearomative C3-arylation of tryptamine derivatives with aryl nonaflates. The intramolecular cyclization of the resulting 3,3-disubstituted indolenines afforded C3a-arylated pyrroloindolines in one pot. We postulate that the formation of complexes between the lithium salts of DHTP and the tryptamine derivative is the key to promoting selective arylation at the C3-position of the indole ring. Furthermore, reactions using homotryptamine derivatives successfully provided C4a-arylated pyridoindolines.journal articl
ヒト肝キメラマウスおよび生理学的薬物速度論モデル解析を用いたヒト不均衡性代謝物の定性的かつ定量的予測
Get PDF静岡県立大学博士（薬学）2023application/pdfdoctoral thesi
脂質代謝を制御する核内受容体群、PPARs・RXRdを対象とした2つの創薬アプローチ：アゴニストの分子機序解明とリガンドスクリーニング系の開発
Get PDF静岡県立大学博士（食品栄養科学）2022application/pdfdoctoral thesi
認知症高齢者に対するコミュニケーションスキルに関する研究―訪問看護師のコミュニケーションスキルの評価とその学習効果の検証―
Get PDF静岡県立大学博士（学術）2022application/pdfdoctoral thesi