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Benzophenone Glucosides and B-Type Proanthocyanidin Dimers from Zambian Cassia abbreviata and Their Trypanocidal Activities
Full text linkTwo benzophenone glucosides (1 and 2), five flavan-3-ol dimers (5–9), and 17 known compounds (3, 4, and 10–24) were identified from the bark extract of Cassia abbreviata. The chemical structures display two points of interest. First, as an unusual characteristic feature of the 1H NMR spectra of 1 and 2, the signals for the protons on glucosidic carbons C-2 are shielded as compared to those generally observed for glucosyl moieties. The geometrically optimized 3D structures derived from conformational analysis and density functional theory (DFT) calculations revealed that this shielding effect originates from intramolecular hydrogen bonds in 1 and 2. Additionally, 3–15 were identified as dimeric B-type proanthocyanidins, which have 2R,3S-absolute-configured C-rings and C-4–C-8″ linkages, as evidenced by X-ray crystallography and by NMR and ECD spectroscopy. These results suggest the structure-determining procedures for some reported dimers need to be reconsidered. The trypanocidal activities of the isolated compounds against Trypanosoma brucei brucei, T. b. gambiense, T. b. rhodesiense, T. congolense, and T. evansi were evaluated, and the active compounds were identified.journal articl
Biofilm 形成Staphylococcus aureus に対するin vitro rifampicin 併用療法の殺菌および耐性に関する研究
Full text link東北医科薬科大学博士（薬学）令和2年度doctoral thesi
卵巣摘出マウスにおける新規選択的エストロゲン受容体モジュレーターBE360 の抗うつ作用およびその作用機序解明に関する研究
Full text link東北医科薬科大学博士（薬学）令和2年度doctoral thesi
Biological activity evaluations of chemical constituents derived from Mongolian medicinal forage plants and their applications in combating infectious diseases and addressing health problems in humans and livestock
Full text linkMongolian nomadic people possess traditional knowledge of wild plants that grow in their areas of habitation. Many of these are forage plants in nature and are consumed by livestock. However, these plants are known to have medicinal and/or toxic properties. To establish a scientific understanding of the plants, and in turn, offer sound knowledge on their applications and effective use, it is essential to collect data pertaining to the chemical constituents of each plant. Therefore, the first objective of this study was to identify and determine the structural constituents of the forage plants that were available to our research group. Furthermore, in an attempt to demonstrate the biological activities of the isolated chemical compounds, we focused on solving some of the social issues affecting Mongolian communities, including protozoan diseases affecting livestock, vectors of infectious diseases, and the general health of humans and their livestock. The results of the chemical constituents derived from Mongolian medicinal plants and their biological activities that were studied in the recent decade are also described herein.journal articl
Isolation and evaluation of virucidal activities of flavanone glycosides and rosmarinic acid derivatives from Dracocephalum spp. against feline calicivirus
Full text linkFeline calicivirus is one of the surrogate viruses of human norovirus. This study aimed to identify virucidal compounds, chemical constituents of plants from the genus Dracocephalum, which are rich in flavonoids and phenylpropanoid oligomers. Four undescribed compounds, including a flavanone glucoside, two stilbenoid glycosides, and a phenylpropanoid amide glycoside, as well as 17 known compounds, were isolated from the Mongolian plants Dracocephalum fruticulosum Stephan ex Willd., and D. nutans L. belonging to the family Lamiaceae. The structures of the compounds were determined based on NMR, MS, and electronic CD spectroscopic data. In addition to these 21 compounds, 15 previously reported compounds from D. foetidum Bunge in C.F. von Ledebour were included, and a total of 36 compounds were evaluated for their virucidal activities against feline calicivirus. Some of the flavanone glycosides and phenylpropanoid oligomers showed virucidal activities, and their structural features are discussed. The findings suggest that isosakuranetin glycosides and phenylpropanoid oligomers may have the potential for norovirus inactivation.journal articl