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Intertrial rest for maximum grip and key pinch strength in Japanese young adults（日本人若者を対象とした最大握力測定および鍵ピンチ力測定の試行間休憩時間）【要旨】
No full text信州大学(Shinshu university)博士（保健学）雑誌に発表。AMERICAN JOURNAL OF OCCUPATIONAL THERAPY. 73(3):inpress (2019).Thesis黒崎 真樹. Intertrial rest for maximum grip and key pinch strength in Japanese young adults（日本人若者を対象とした最大握力測定および鍵ピンチ力測定の試行間休憩時間）【要旨】. 信州大学, 2019, 博士論文.thesi
Histopathological findings of pregnancy-induced hypertension: histopathology of early-onset type reflects two-stage disorder theory（妊娠高血圧症候群の病理組織学的所見は早発型において二段階発症説を反映している）
No full text信州大学(Shinshu university)博士（医学）雑誌に発表。VIRCHOWS ARCHIV. 472(4):635-642 (2018); doi:10.1007/s00428-018-2315-3.Thesis立石 文子. Histopathological findings of pregnancy-induced hypertension: histopathology of early-onset type reflects two-stage disorder theory（妊娠高血圧症候群の病理組織学的所見は早発型において二段階発症説を反映している）. 信州大学, 2019, 博士論文.doctoral thesi
Visualization of multiple organ amyloid involvement in systemic amyloidosis using 11C-PiB PET imaging（11C-PiB PETを用いた全身性アミロイドーシスにおける多臓器アミロイド沈着の評価）
No full text信州大学(Shinshu university)博士（医学）雑誌に発表。EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 45(3):452-461 (2018); doi:10.1007/s00259-017-3814-1.Thesis江澤 直樹. Visualization of multiple organ amyloid involvement in systemic amyloidosis using 11C-PiB PET imaging（11C-PiB PETを用いた全身性アミロイドーシスにおける多臓器アミロイド沈着の評価）. 信州大学, 2019, 博士論文.doctoral thesi
Annexin A1 expression is correlated with malignant potential of renal cell carcinoma（腎細胞癌におけるアネキシンA1の発現は、悪性度と相関する）
No full text信州大学(Shinshu university)博士（医学）雑誌に発表。INTERNATIONAL JOURNAL OF UROLOGY. 26(2):284-290 (2019); doi:10.1111/iju.13869.Thesis山ノ井 万里子. Annexin A1 expression is correlated with malignant potential of renal cell carcinoma（腎細胞癌におけるアネキシンA1の発現は、悪性度と相関する）. 信州大学, 2019, 博士論文.doctoral thesi
Watertight Robust Osteoconductive Barrier For Complex Skull Base Reconstruction: An Expanded-Endoscopic Endonasal Experimental Study.（WROバリヤー：広範頭蓋底腫瘍に対する経鼻内視鏡手術における新たな頭蓋底再建法）
No full text信州大学(Shinshu university)博士（医学）雑誌に発表。NEUROLOGIA MEDICO-CHIRURGICA. 59(3):79-88 (2019); doi:10.2176/nmc.oa.2018-0262.ThesisNAGM ALHUSAIN. Watertight Robust Osteoconductive Barrier For Complex Skull Base Reconstruction: An Expanded-Endoscopic Endonasal Experimental Study.（WROバリヤー：広範頭蓋底腫瘍に対する経鼻内視鏡手術における新たな頭蓋底再建法）. 信州大学, 2019, 博士論文.doctoral thesi
Development of electrospun functional nanofibers for antibacterial and coloration performances （エレクトロスピニングによる抗菌性・着色性機能ナノファイバーの開発に関する研究）
No full text信州大学(Shinshu university)博士（工学）この博士論文は、次の学術雑誌論文を一部に使用しています。JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS. 106(3):1121-1128 (2018); doi:10.1002/jbm.b.33925. © 2017 Wiley Periodicals, Inc.CARBOHYDRATE POLYMERS. 207:640-649 (2019); doi:10.1016/j.carbpol.2018.12.029. © 2018 Elsevier Ltd.APPLIED NANOSCIENCE. 9(8):1661-1670 (2019); doi:10.1007/s13204-019-00952-3. © King Abdulaziz City for Science and Technology 2019.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS. 98:1179-1195 (2019); doi:10.1016/j.msec.2019.01.017. © 2019 Elsevier B.V.ULTRASONICS SONOCHEMISTRY. 39:34-38 (2017); doi:10.1016/j.ultsonch.2017.04.010. © 2017 Elsevier B.V.APPLIED NANOSCIENCE. 8(6):1505-1514 (2018); doi:10.1007/s13204-018-0823-8. © Springer-Verlag GmbH Germany, part of Springer Nature 2018.ULTRASONICS SONOCHEMISTRY. 51:399-405 (2019); doi:10.1016/j.ultsonch.2018.07.035. © 2018 Elsevier B.V.ThesisJATOI ABDUL WAHAB. Development of electrospun functional nanofibers for antibacterial and coloration performances （エレクトロスピニングによる抗菌性・着色性機能ナノファイバーの開発に関する研究）. 信州大学, 2019, 博士論文. 博士（工学）, 甲第699号, 平成31年03月20日授与.doctoral thesi
コクサッキーウイルスB2感染症により血球貪食性リンパ組織球症様の所見を呈した新生児の１例
No full textArticle信州医学雑誌 67(4): 253-258(2019)journal articl
Deafness in occludin-deficient mice with dislocation of tricellulin and progressive apoptosis of the hair cells
No full textOccludin is the first identified protein in the tight junction (TJ), but its function has remained for the most part obscure. TJs have been demonstrated to play important roles in the inner ear function, and occludin is expressed in all the epithelial TJs in the inner ear. Thus, we examined the inner ears of occludin-deficient (Occ(-/-)) mice. Although inner ears initially developed normally in Occ(-/-) mice, apoptosis occurs in hair cells in the organ of Corti around day 12 after birth, and deafness develops. Since hair cell degeneration was not observed in cochlear explant cultures of Occ(-/-) mice, environmental changes were considered to be the trigger of cell death. As for the vestibular system, both the morphologies and functions are normal in Occ(-/-) mice. These phenotypes of Occ(-/-) mice are very similar with those of claudin-14 or claudin-9 deficient mice, leading us to speculate on the existence of imbalance induced by TJ abnormalities, such as localized ionic components. Moreover, the occludin deficiency led to dislocalization of tricellulin, a gene responsible for human deafness DFNB49. The deafness in Occ(-/-) mice may be due to this dislocalization of tricellulin.ArticleBIOLOGY OPEN.3(8):759-766(2014)journal articl
Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target
No full textAggressive natural killer-cell (NK-cell) leukemia (ANKL) is an extremely aggressive malignancy with dismal prognosis and lack of targeted therapies. Here, we elucidate the molecular pathogenesis of ANKL using a combination of genomic and drug sensitivity profiling. We study 14 ANKL patients using whole-exome sequencing (WES) and identify mutations in STAT3 (21%) and RAS-MAPK pathway genes (21%) as well as in DDX3X (29%) and epigenetic modifiers (50%). Additional alterations include JAK-STAT copy gains and tyrosine phosphatase mutations, which we show recurrent also in extranodal NK/T-cell lymphoma, nasal type (NKTCL) through integration of public genomic data. Drug sensitivity profiling further demonstrates the role of the JAK-STAT pathway in the pathogenesis of NK-cell malignancies, identifying NK cells to be highly sensitive to JAK and BCL2 inhibition compared to other hematopoietic cell lineages. Our results provide insight into ANKL genetics and a framework for application of targeted therapies in NK-cell malignancies.ArticleNATURE COMMUNICATIONS.9:1567(2018)journal articl
特定健診データ市町村別集計結果の活用方法の提案
No full text要旨：特定健康診査に係る健診データのうち、県健康福祉部、長野県国民健康保険団体連合会、全国健康保険協会長野県支部の三者の共同により作成されたデータにはリスク因子の市町村別標準化該当比が示されている。今回、既存の市町村別集計結果を保健事業への活用する方法を検討するため、リスク因子の市町村別標準化該当比を目的変数とし、標準的な質問票の該当者割合を説明変数とした重回帰分析を行った。市町村別標準化該当比には身体活動や食習慣の関連がみられたが、現在提供されている質問票データだけでは年齢や職業等の違いにより影響を受ける可能性があり、今後、保健事業の重点施策の検討に活用するためには、健康課題の要因分析を前提とした年齢調整値や職業別集計結果等のデータが必要と考えられた。Article信州公衆衛生雑誌 14(1): 32-33(2019)journal articl