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Liver Stiffness-Spleen Size-to-Platelet Ratio Risk Score Identifies Esophageal Varices in Japanese Patients with Chronic Hepatitis C（日本人のC型慢性肝炎患者においてLSPSは食道静脈瘤を判別する）
No full text信州大学(Shinshu university)博士（医学）雑誌に発表。HEPATOLOGY RESEARCH. 46(9):884-889 (2016); doi:10.1111/hepr.12631.Thesis柴田 壮一郎. Liver Stiffness-Spleen Size-to-Platelet Ratio Risk Score Identifies Esophageal Varices in Japanese Patients with Chronic Hepatitis C（日本人のC型慢性肝炎患者においてLSPSは食道静脈瘤を判別する）. 信州大学, 2019, 博士論文.doctoral thesi
長野県中野市におけるチョウゲンボウの餌場環境の評価
No full textCommon kestrel mainly forage voles in grasslands and farmland.Nakano city in Nagano prefecture is characterized by fruit cultivation. From the spring to summer, foraging habitat evaluation of Common kestrels was investigated by radio-tracking in Nakano City.We recorded the locations and the habitat use by transferring the information onto a 1:3000 map.In 2017 and 2018,the home-range size for one juvenile male,one adult male and one immature female was calculated using the 95% and 50% kernel method. The area of the juvenile male home-range was 12.2ha, the adult male was 1982.4ha and the immature female was 17.3ha by 95% kernel method. The area of the juvenile male home-range was 0.9ha,the adult male was 389.1ha and the immature female was 13.4ha by 50% kernel method.Kestrels actively selected rice fields than fruits garden,and preyed on voles and insects.In the spring,when the rice field was not cultivated,kestrels foraged voles by the center part of the rice field. In the summer,the grasslands sides of the rice fields managed by grass cutting were used by foraging of kestrels. We evaluated rice fields as the most important foraging habitat of Common kestrel in Nakano city.Article志賀自然教育研究施設研究業績(56) : 1-6(2019)departmental bulletin pape
Submanifolds of statisticalmanifolds admitting almost complex structures
No full textThe 42-th Symposium on Finsler Geometry. Nov. 1-4, 2007. Nagasaki, Japan.ArticleTAKANO KAZUHIKO. "Submanifolds of statisticalmanifolds admitting almost complex structures". Proceedings of the 42-th Symposium on Finsler Geometry. Nagasaki, 2007-11-01/04. Society of Finsler Geometry, 2008, p. 38-41.conference pape
Relationship between Sympathetic Nerve Activity Evaluated by Pulse Rate Variability and Blood Pressure Early in the Morning in Sleep Disordered Breathing
No full textArticle信州医学雑誌 67(4): 241-251(2019)journal articl
A new cyano-substituted fluorescamine superior to its original form as a fluorescent probe for amino acid detection
No full textAvailable online 7 February 2018.Synthesis and spectral study of two new cyano-substituted fluorescamine as the fluorescent probes for amino acid detection have been carried out comparing with the original fluorescamine. Of the three compounds, the derivative with a cyano group at the meta-position on the 4-phenyl group was found to be superior to the original one in the reactivity toward some amino acids as well as the fluorescence intensity of the adducts. The fluorescent amino acid adducts were also applied to the peroxyoxalate chemiluminescence system as the fluorophores, in which the derivative described above was found to be more effective also in chemiluminescence than the original one. (C) 2018 Elsevier Ltd. All rights reserved.ArticleTETRAHEDRON LETTERS. 59(12):1104-1107 (2018)journal articl
Biofabricated Structures Reconstruct Functional Urinary Bladders in Radiation-Injured Rat Bladders
No full textThe ability to repair damaged urinary bladders through the application of bone marrow-derived cells is in the earliest stages of development. We investigated the application of bone marrow-derived cells to repair radiation-injured bladders. We used a three-dimensional bioprinting robot system to biofabricate bone marrow-derived cell structures. We then determined if the biofabricated structures could restore the tissues and functions of radiation-injured bladders. The bladders of female 10-week-old Sprague-Dawley (SD) rats were irradiated with 2-Gy once a week for 5 weeks. Adherent and proliferating bone marrow-derived cells harvested from the femurs of male 17-week-old green fluorescence protein-transfected Tg-SD rats were cultured in collagen-coated flasks. Bone marrow-derived cell spheroids were formed in 96-well plates. Three layers of spheroids were assembled by the bioprinter onto a 9x9 microneedle array. The assembled spheroids were perfusion cultured for 7 days, and then the microneedle array was removed. Two weeks after the last radiation treatment, the biofabricated structures were transplanted into an incision on the anterior wall of the bladders (n=10). Control rats received the same surgery but without the biofabricated structures (sham-structure, n=12). At 2 and 4 weeks after surgery, the sham-structure control bladder tissues exhibited disorganized smooth muscle layers, decreased nerve cells, and significant fibrosis with increased presence of fibrosis-marker P4HB-positive cells and hypoxia-marker hypoxia-induced factor 1 (HIF1)-positive cells. The transplanted structures survived within the recipient tissues, and blood vessels extended within them from the recipient tissues. The bone marrow-derived cells in the structures differentiated into smooth muscle cells and formed smooth muscle clusters. The recipient tissues near the transplanted structures had distinct smooth muscle layers and reconstructed nerve cells, and only minimal fibrosis with decreased presence of P4HB- and HIF1-positive cells. At 4 weeks after surgery, the sham-structure control rats exhibited significant urinary frequency symptoms with irregular and short voiding intervals, and low micturition volumes. In contrast, the structure-transplanted rats had regular micturition with longer voiding intervals and higher micturition volumes compared with the control rats. Furthermore, the residual volume of the structure-transplanted rats was lower than for the controls. Therefore, transplantation of biofabricated bone marrow-derived cell structures reconstructed functional bladders.ArticleTISSUE ENGINEERING PART A.24(21-22):1574-1587(2018)journal articl
妊娠期からの切れ目ない支援についての多職種連携母子保健システムの地域介入研究－須坂トライアル－
No full text要旨：周産期メンタルヘルスケアを多職種で連携して行う有効な地域母子保健の介入プログラムの開発と効果検証を目的とした。このプログラムを平成26 年度長野県須坂市の母子保健事業として実施し（以下「須坂トライアル」という。）、事業開始前の平成25 年度と比較して、介入プログラムの効果を検証した。事業開始後に妊娠届出をした妊婦210 人と、事業開始前に妊娠届出をした妊婦139 人について、産後の3 〜4 か月児健診時のエジンバラ産後うつ病質問票の合計点および母子保健サービスの受療状況を比較した。須坂トライアルが地域全体の母親のメンタルヘルスを向上することが示された。また、須坂トライアルが親子と保健センターとのつながりをより深くし母子保健サービスの受療率を向上する効果があることが示された。Article信州公衆衛生雑誌 14(1): 52-53(2019)journal articl
挙動による欺罔行為について : いわゆる「作為と不作為の区別」論からの検討
No full textArticle信州大学経法論集 7:1-32(2019)departmental bulletin pape
