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信州大学学生相談センターにおける20018年度の活動報告 : 「修学」を主訴とする相談の様相
No full textArticle信州大学総合人間科学研究 14 : 78-88(2020)departmental bulletin pape
Suppressing the effect of lithium dendritic growth by the addition of magnesium bis(trifluoromethanesulfonyl)amide
No full textPractical applications of Li-S and Li-air batteries require the morphology of the Li metal negative electrode during charge/discharge (i.e., Li-deposition/dissolution) cycling to be precisely controlled. Herein, we used magnesium bis(trifluoromethanesulfonyl)amide [Mg(TFSA)(2)] as an electrolyte additive to suppress the growth of Li dendrites, utilizing the occurrence of an alloying reaction between the initially substrate-deposited Mg and the subsequently deposited Li. Notably, no metallic Mg formation and no change in Li deposition morphology were observed at an electrolyte composition of 0.1 M Mg(TFSA)(2) + 0.9 M LiTFSA/triglyme, irrespective of the applied potential. In contrast, increasing the Mg salt concentration to 0.5 M resulted in the deposition of interconnected granules, reflecting a dramatic morphology improvement. X-ray diffraction analysis revealed the occurrence of the abovementioned alloying, which finally afforded a deposit composition of Li0.9Mg0.1 via the formation of an intermediate Li0.14Mg0.86 phase. Importantly, the deposits obtained under various applied potentials were relatively smooth, with no needle-like morphology observed.ArticlePHYSICAL CHEMISTRY CHEMICAL PHYSICS.20(2):1127-1133(2018)journal articl
『増鏡』 : 生々しい「王」の姿を求めて
No full textBook chapter渡辺匡一. "『増鏡』 : 生々しい「王」の姿を求めて". 「新しい作品論」へ、「新しい教材論」へ : 文学研究と国語教育研究の交差. 前田雅之, 小嶋菜温子, 田中実, 須貝千里編. 右文書院, 2003, p. 279-297, (古典編, 1).boo
eALPS を活用した文化人類学の授業実践報告 : 世界の指導者
No full textArticle信州大学教育学部附属次世代型学び研究開発センター紀要 教育実践研究 18: 41-48(2019)departmental bulletin pape
野口雨情と石井鶴三 : 信州大学蔵石井鶴三関連資料から
No full textArticle信州大学附属図書館研究. 9 : 137-144(2020)departmental bulletin pape
Efficient generation of an oxidopyrylium ylide using a Pd catalyst and its [5+2] cycloadditions with several dipolarophiles
No full textAn efficient method for the generation of an oxidopyrylium ylide from 6-acetoxy-6-acetoxymethyl-2H-pyran-3(6H)-one using a Pd catalyst and [5+2] cycloadditions of the resulting ylide are described. Among substituted styrene derivatives as dipolarophiles, electron-rich styrenes showed higher yield (up to 80%). The [5+2] cycloaddition reactions can also be applied to exo-methylene cyclic compounds, and an improved method for the synthesis of polygalolide intermediate has been demonstrated.ArticleCHEMICAL COMMUNICATIONS.54(9):1109-1112(2018)journal articl
Targeted mutagenesis in chicken using CRISPR/Cas9 system
No full textThe CRISPR/Cas9 system is a simple and powerful tool for genome editing in various organisms including livestock animals. However, the system has not been applied to poultry because of the difficulty in accessing their zygotes. Here we report the implementation of CRISPR/Cas9-mediated gene targeting in chickens. Two egg white genes, ovalbumin and ovomucoid, were efficiently (> 90%) mutagenized in cultured chicken primordial germ cells (PGCs) by transfection of circular plasmids encoding Cas9, a single guide RNA, and a gene encoding drug resistance, followed by transient antibiotic selection. We transplanted CRISPR-induced mutant-ovomucoid PGCs into recipient chicken embryos and established three germline chimeric roosters (G0). All of the roosters had donor-derived mutant-ovomucoid spermatozoa, and the two with a high transmission rate of donor-derived gametes produced heterozygous mutant ovomucoid chickens as about half of their donor-derived offspring in the next generation (G1). Furthermore, we generated ovomucoid homozygous mutant offspring (G2) by crossing the G1 mutant chickens. Taken together, these results demonstrate that the CRISPR/Cas9 system is a simple and effective gene-targeting method in chickens.ArticleSCIENTIFIC REPORTS.6:23980(2016)journal articl