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長野県における凍り豆腐消費動向の地域差
No full text正誤表有(2018年11月9日 公開)Article信州大学経法論集 4:51-111(2018)departmental bulletin pape
Parameters of hydrothermal gelation of chitin nanofibers determined using a severity factor
No full textFirst Online: 28 September 2018The hydrothermal gelation of α- and β-chitin nanofibers (α- and β-ChNFs) prepared at neutral and acidic pH was conducted by heating them to 120, 160, 180, and 200 °C in a sealed reactor. The optical transmittance and mechanical strength of β-ChNFs gelated at the acidic pH were determined for the first time using a severity factor defined as a function of the integrated heating time and temperature. The width of β-ChNFs increased after the hydrothermal treatment, indicating that these fibers strongly adhered to each other to form a network structure during gelation. Furthermore, the hydrothermal gelation of α- and β-ChNFs with different degrees of disintegration prepared at the neutral and acidic pH was conducted. It was found that the hydrothermal treatment of α-chitin must be performed at the acidic pH to obtain a self-sustaining hydrogel of well-disintegrated NFs. The disintegration of β-chitin into NFs occurred more easily at the acidic pH than under the neutral conditions; however, in the latter case, the same disintegration degree of β-ChNFs could be achieved by increasing the number of disintegration steps. At the same disintegration degree, the strength of the self-sustaining hydrogel obtained at the neutral conditions was greater than that of the gel prepared at the acidic pH, indicating that the electrostatic repulsion caused by acid addition negatively affected the formation of the hydrogel network structure. To maximize the efficiency of the hydrothermal gelation process, ChNFs should be as thin as possible and electrostatic repulsion forces must be controlled.ArticleCELLULOSE. 25(12):6873-6885 (2018)journal articl
俵万智の短歌を扱った授業実践における省察 : 「知識・技能」と「思考力・判断力・表現力」を繋ぐ指導を目指して
No full textArticle信大国語教育 28 : 16-24(2018)journal articl
A multicenter,randomized controlled trial of individualized occupational therapy for patients with schizophrenia in Japan（統合失調症患者に対する個別作業療法：多施設共同ランダム化比較試験）
No full text信州大学(Shinshu university)博士（保健学）雑誌に発表。PLOS ONE. 13(4):e0193869 (2018); doi:10.1371/journal.pone.0193869.Thesis島田 岳. A multicenter,randomized controlled trial of individualized occupational therapy for patients with schizophrenia in Japan（統合失調症患者に対する個別作業療法：多施設共同ランダム化比較試験）. 信州大学, 2018, 博士論文.doctoral thesi
Osteoarthritis Progression of the Shoulder: A Long-Term Follow-Up After Mini-Open Rotator Cuff Repair（ミニオープン法による腱板修復術後長期経過例における肩関節症性変化の特徴）
No full text信州大学(Shinshu university)博士（医学）雑誌に発表。JOURNAL OF ORTHOPAEDIC SURGERY. 26(2):(2018); doi:10.1177/2309499018768106.Thesis松葉 友幸. Osteoarthritis Progression of the Shoulder: A Long-Term Follow-Up After Mini-Open Rotator Cuff Repair（ミニオープン法による腱板修復術後長期経過例における肩関節症性変化の特徴）. 信州大学, 2018, 博士論文.doctoral thesi
Effects of hypertension and antihypertensive treatments on sulfatide levels in serum and its metabolism（高血圧や降圧治療は血清スルファチドレベルとその代謝に影響する）
No full text信州大学(Shinshu university)博士（医学）雑誌に発表。HYPERTENSION RESEARCH. 42(5):598-609 (2019); doi:10.1038/s41440-018-0160-z.Thesis郭 然. Effects of hypertension and antihypertensive treatments on sulfatide levels in serum and its metabolism（高血圧や降圧治療は血清スルファチドレベルとその代謝に影響する）. 信州大学, 2018, 博士論文.doctoral thesi
KIR2DL2 combined with HLA-C1 confers risk of hepatitis C virus-related hepatocellular carcinoma in younger patients（KIR2DL2とHLA-C1の組み合わせはC型肝炎ウイルス関連肝細胞癌の若年発症リスクと関連する）
No full text信州大学(Shinshu university)博士（医学）雑誌に発表。ONCOTARGET. 9(28):19650-19661 (2018); doi:10.18632/oncotarget.24752.Thesis齊藤 博美. KIR2DL2 combined with HLA-C1 confers risk of hepatitis C virus-related hepatocellular carcinoma in younger patients（KIR2DL2とHLA-C1の組み合わせはC型肝炎ウイルス関連肝細胞癌の若年発症リスクと関連する）. 信州大学, 2018, 博士論文.doctoral thesi
Lower number of 5-hydroxymethylcytosine-expressing cells in plasma cell myeloma than in reactive plasma cell hyperplasia: A useful immunohistochemical approach for identification of neoplastic plasma cells（多発性骨髄腫では反応性形質細胞過形成と比較して 5-ヒドロキシメチルシトシン発現細胞の減少が見られる：腫瘍性形質細胞の同定に有用な免疫組織化学的手法）
No full text信州大学(Shinshu university)博士（医学）雑誌に発表。PATHOLOGY. 51(1):81-85 (2019); doi:10.1016/j.pathol.2018.10.006.Thesis大谷 真紀. Lower number of 5-hydroxymethylcytosine-expressing cells in plasma cell myeloma than in reactive plasma cell hyperplasia: A useful immunohistochemical approach for identification of neoplastic plasma cells（多発性骨髄腫では反応性形質細胞過形成と比較して 5-ヒドロキシメチルシトシン発現細胞の減少が見られる：腫瘍性形質細胞の同定に有用な免疫組織化学的手法）. 信州大学, 2018, 博士論文.doctoral thesi
LOX-1 Plays an Important Role in Ischemia-Induced Angiogenesis of Limbs
No full textLOX-1, lectin-like oxidized low-density lipoprotein (LDL) receptor-1, is a single transmembrane receptor mainly expressed on endothelial cells. LOX-1 mediates the uptake of oxidized LDL, an early step in atherosclerosis; however, little is known about whether LOX-1 is involved in angiogenesis during tissue ischemia. Therefore, we examined the role of LOX-1 in ischemia-induced angiogenesis in the hindlimbs of LOX-1 knockout (KO) mice. Angiogenesis was evaluated in a surgically induced hindlimb ischemia model using laser Doppler blood flowmetry (LDBF) and histological capillary density (CD) and arteriole density (AD). After right hindlimb ischemia, the ischemic/nonischemic hindlimb blood flow ratio was persistently lower in LOX-1 KO mice than in wild-type (WT) mice. CD and AD were significantly smaller in LOX-1 KO mice than in WT mice on postoperative day 14. Immunohistochemical analysis revealed that the number of macrophages infiltrating ischemic tissues was significantly smaller in LOX-1 KO mice than in WT mice. The number of infiltrated macrophages expressing VEGF was also significantly smaller in LOX-1 KO mice than in WT mice. Western blot analysis and ROS production assay revealed that LOX- KO mice show significant decrease in Nox2 expression, ROS production and HIF-1α expression, the phosphorylation of p38 MAPK and NF-κB p65 subunit as well as expression of redox-sensitive vascular cell adhesion molecule-1 (VCAM-1) and LOX-1 itself in ischemic muscles, which is supposed to be required for macrophage infiltration expressing angiogenic factor VEGF. Reduction of VEGF expression successively suppressed the phosphorylation of Akt and eNOS, which accelerated angiogenesis, in the ischemic leg of LOX-1 KO mice. Our findings indicate that LOX-1 plays an important role in ischemia-induced angiogenesis by 1) Nox2-ROS-NF-κB activation, 2) upregulated expression of adhesion molecules: VCAM-1 and LOX-1 and 3) promoting macrophage infiltration, which expresses angiogenic factor VEGF.ArticlePLOS ONE.9(12):e114542(2014)journal articl