Repository of Shinshu
Not a member yet
23655 research outputs found
Sort by
自家骨髄幹細胞・脂肪組織由来幹細胞を利用した細胞シートを用いた下部尿路再生療法
No full text研究種目：基盤研究(C)研究期間：2014～2016課題番号：26462441研究代表者：石塚 修研究者番号：20184541Other2014～2016年度科学研究費助成事業（基盤研究(C)）研究成果報告書 課題番号：26462441 研究代表者：石塚 修research repor
ＣＮＴを応用した高機能生体材料創製のためのＣＮＴ・生体界面技術の構築と安全性評価
No full text研究種目：基盤研究(A)研究期間：2012～2016課題番号：24241045研究代表者：齋藤 直人研究者番号：80283258Other2012～2016年度科学研究費助成事業（基盤研究(A)）研究成果報告書 課題番号：24241045 研究代表者：齋藤 直人research repor
Phase II study of the immune-checkpoint inhibitor ipilimumab plus dacarbazine in Japanese patients with previously untreated, unresectable or metastatic melanoma
No full textPurposeIpilimumab (IPI), a monoclonal antibody against immune-checkpoint receptor cytotoxic T lymphocyte antigen-4, is designed to enhance antitumor T cell function. IPI 10 mg/kg plus dacarbazine (DTIC) significantly improved overall survival in a phase 3 study involving predominantly Caucasian patients, with an adverse event (AE) profile similar to that of IPI monotherapy. We conducted a single-arm, phase 2 study to evaluate the safety and efficacy of IPI plus DTIC in Japanese patients.MethodsPreviously untreated patients with unresectable stage III or IV melanoma received IPI 10 mg/kg plus DTIC 850 mg/m2 every 3 weeks for four doses (q3w × 4), followed by DTIC q3w × 4 and then IPI every 12 weeks until disease progression or intolerable toxicity.ResultsAll 15 treated patients reported drug-related AEs, the most common of which were increases in alanine aminotransferase (n = 12, 80 %) and aspartate aminotransferase (n = 11, 73 %). Treatment-related serious AEs were reported in 11 (73 %) patients. Nine patients (60 %) discontinued treatment due to drug-related toxicities. Immune-related AEs (irAEs) were reported in 14 patients (93 %). The most frequent irAEs were liver (n = 12, 80 %) and skin (n = 10, 67 %) toxicities. Five deaths were reported; all were caused by progressive disease. Efficacy evaluation showed one complete response, one partial response and four patients with stable disease. Best overall response rate was 13 % (2/15), and the disease control rate was 40 % (6/15). The study was terminated early due to frequent, high-grade liver toxicities.ConclusionsIPI 10 mg/kg plus DTIC 850 mg/m2 was not considered tolerable in the Japanese patient population.ArticleCANCER CHEMOTHERAPY AND PHARMACOLOGY.76(5):969-975(2015)journal articl
Potential Roles of ASC, a Proapoptotic Protein, for Determining the Cisplatin Susceptibility of Lung Cancer Cells（アポトーシス促進性蛋白質であるASCは肺癌細胞のシスプラチン感受性を決定する役割を担う）
No full text信州大学(Shinshu university)博士（医学）雑誌に発表。TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE. 244(2):133-144 (2018); doi:10.1620/tjem.244.133.Thesis境澤 隆夫. Potential Roles of ASC, a Proapoptotic Protein, for Determining the Cisplatin Susceptibility of Lung Cancer Cells（アポトーシス促進性蛋白質であるASCは肺癌細胞のシスプラチン感受性を決定する役割を担う）. 信州大学, 2018, 博士論文.doctoral thesi
Impact of a negative D-dimer result on the initial assessment of acute aortic dissection（急性大動脈解離の初期評価におけるD-dimer陰性の影響）
No full text信州大学(Shinshu university)博士（医学）雑誌に発表。INTERNATIONAL JOURNAL OF CARDIOLOGY. 258:232-236 (2018); doi:10.1016/j.ijcard.2018.01.104.Thesis新田 憲市. Impact of a negative D-dimer result on the initial assessment of acute aortic dissection（急性大動脈解離の初期評価におけるD-dimer陰性の影響）. 信州大学, 2018, 博士論文.doctoral thesi
Radiographic measurements of C-2 in patients with atlas assimilation（環椎癒合症例における軸椎椎弓根と椎弓の放射線学的検討）
No full text信州大学(Shinshu university)博士（医学）雑誌に発表。JOURNAL OF NEUROSURGERY-SPINE. 21(5):732-735 (2014); doi:10.3171/2014.7.SPINE131087.Thesis青山 達郎. Radiographic measurements of C-2 in patients with atlas assimilation（環椎癒合症例における軸椎椎弓根と椎弓の放射線学的検討）. 信州大学, 2018, 博士論文.doctoral thesi
リンパ循環学から視た皮膚の美しさと健康
No full textLymph formation and propulsion are determined by the interplay of multiple factors, both passive and active, that control how lymphatic vessels behave as pumps and/or conduits. Passive factors influencing lymph propulsion include hydrostatic pressure gradients across and along lymphatic vessels, tissue compression , respiratory movements, and gravitational forces. Active lymph propulsion is achieved by the spontaneous, rhythmic contractions of collecting lymphatic vessels , which serve as an essential pump mechanism to propel lymph up hill against a hydrostatic pressure gradient from peripheral lymphatics through lymph nodes into the thoracic duct. The lymphatic pump exhibits cardiac-like behavior in several respects such that pump performance can be analyzed using cardiac indicts. Other aspects of lymphatic vessel behavior resemble those of blood vessels. Like arterioles, lymphatics have a certain degree of basal tone, and respond to imposed, intraluminal flow gradients. The lymphatic system is also concerned with the immune system. Lymph nodes are the organs where innate immune responses lead to acquired immunity, where some of our most devastating pathogens evade immunity, and where auto -reactive lymphocyte first encounter tissue-specific self-antigens and are either tolerated or activated.Article日本香粧品学会誌. 34(4):292-296 (2010)journal articl
感性計測による着衣快適感のメカニズム解明と評価に関する研究
No full text研究種目：基盤研究（Ｂ）研究期間：2013～2015課題番号：25280099研究代表者：上條 正義研究者番号：70224665Other2013～2015年度科学研究費助成事業（基盤研究（Ｂ））研究成果報告書 課題番号：25280099 研究代表者：上條 正義research repor
Effect of Footrest Angle on Decrement of Leg Swelling while Sitting
No full textSitting in the comfort of chairs is an important factor of daily life, but leg swelling results in languor of lower legs and decreases sitting comfort. Many studies have examined the mechanism of increased leg swelling; however, few have investigated the mechanism of decrease leg swelling. We studied the effect of the footrest angle on decreases in leg swelling by measuring leg swelling with bioelectrical impedance method (BI method) and blood flow with near-infrared spectroscopy (NIRS). We performed the sitting experiment with six volunteers. It comprised three parts; (1) lying supine for 20 minutes to alleviate leg swelling, (2) sitting on a high stool for 30 minutes to increase leg swelling, (3) sitting on a trial chair with a footrest for 30 minutes to decrease leg swelling in order to research the differences among three footrest angles (0°, 15°, and 30°). By the results of the BI method, leg swelling increased by sitting on the high stool and decreased by sitting on the trial chair with a 30° footrest. By the results of NIRS, the quantity of deoxygenated hemoglobin (deOXY-Hb) increased by sitting on the high stool and the quantity of oxygenated hemoglobin (OXY-Hb) increased by sitting on the trial chair. In comparison of leg swelling and blood flow, it is considered that increases in deOXY-Hb influences gains in leg swelling, and increases in OXY-Hb influences reductions in leg swelling.ArticleInternational Journal of Affective Engineering.13(3):197-203(2014)journal articl