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Reproductive tract complication risks following Chlamydia trachomatis infections: a long-term prospective cohort study from 2008 to 2022
No full textImproving the learning capacity of regional health systems for their transformation towards health and well-being systems: a qualitative study of ten Dutch regions
No full textGenomics Research of Lifetime Depression in the Netherlands: The BIObanks Netherlands Internet Collaboration (BIONIC) Project.
No full textIn this cohort profile article we describe the lifetime major depressive disorder (MDD) database that has been established as part of the BIObanks Netherlands Internet Collaboration (BIONIC). Across the Netherlands we collected data on Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) lifetime MDD diagnosis in 132,850 Dutch individuals. Currently, N = 66,684 of these also have genomewide single nucleotide polymorphism (SNP) data. We initiated this project because the complex genetic basis of MDD requires large population-wide studies with uniform in-depth phenotyping. For standardized phenotyping we developed the LIDAS (LIfetime Depression Assessment Survey), which then was used to measure MDD in 11 Dutch cohorts. Data from these cohorts were combined with diagnostic interview depression data from 5 clinical cohorts to create a dataset of N = 29,650 lifetime MDD cases (22%) meeting DSM-5 criteria and 94,300 screened controls. In addition, genomewide genotype data from the cohorts were assembled into a genomewide association study (GWAS) dataset of N = 66,684 Dutch individuals (25.3% cases). Phenotype data include DSM-5-based MDD diagnoses, sociodemographic variables, information on lifestyle and BMI, characteristics of depressive symptoms and episodes, and psychiatric diagnosis and treatment history. We describe the establishment and harmonization of the BIONIC phenotype and GWAS datasets and provide an overview of the available information and sample characteristics. Our next step is the GWAS of lifetime MDD in the Netherlands, with future plans including fine-grained genetic analyses of depression characteristics, international collaborations and multi-omics studies
To breathe or not to breathe: Inhalational exposure to heavy metals and related health risk
No full textThis study reviewed scientific literature on inhalation exposure to heavy metals (HMs) in various indoor and outdoor environments and related carcinogenic and non-carcinogenic risk. A systematic search in Web of Science, Scopus, PubMed, Embase, and Medline databases yielded 712 results and 43 articles met the requirements of the Population, Exposure, Comparator, and Outcomes (PECO) criteria. Results revealed that HM concentrations in most households exceeded the World Health Organization (WHO) guideline values, indicating moderate pollution and dominant anthropogenic emission sources of HMs. In the analyzed schools, universities, and offices low to moderate levels of air pollution with HMs were revealed, while in commercial environments high levels of air pollution were stated. The non-carcinogenic risk due to inhalation HM exposure exceeded the acceptable level of 1 in households, cafes, hospitals, restaurants, and metros. The carcinogenic risk for As and Cr in households, for Cd, Cr, Ni, As, and Co in educational environments, for Pb, Cd, Cr, and Co in offices and commercial environments, and for Ni in metros exceeded the acceptable level of 1 × 10-4. Carcinogenic risk was revealed to be higher indoors than outdoors. This review advocates for fast and effective actions to reduce HM exposure for safer breathing
Vaccine effectiveness against COVID-19 related hospital admission in the Netherlands by medical risk condition: A test-negative case-control study
No full textOriginal COVID-19 priming regimen impacts the immunogenicity of bivalent BA.1 and BA.5 boosters
No full textEarly COVID-19 vaccine effectiveness of XBB.1.5 vaccine against hospitalisation and admission to intensive care, the Netherlands, 9 October to 5 December 2023
No full textImmunogenicity and reactogenicity of intradermal mRNA-1273 SARS-CoV-2 vaccination: a non-inferiority, randomized-controlled trial.
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