BIOREpository (Faculty of Biology, University of Belgrade)
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A Comprehensive Overview of Antibacterial Agents for Combating Multidrug-Resistant Bacteria: The Current Landscape, Development, Future Opportunities, and Challenges
No full textBackground/Objectives: Antimicrobial resistance poses a major public health challenge. The World Health Organization has identified 15 priority pathogens that require prompt development of new antibiotics. This review systematically evaluates the antibacterial resistance of the most significant bacterial pathogens, currently available treatment options, as well as complementary approaches for the management of infections caused by the most challenging multidrug-resistant (MDR) bacteria. For carbapenem-resistant Gram-negative bacteria, treatment options include combinations of beta-lactam antibiotics and beta-lactamase inhibitors, a novel siderophore cephalosporin, known as cefiderocol, as well as older antibiotics like polymixins and tigecycline. Treatment options for Gram-positive bacteria are vancomycin, daptomycin, linezolid, etc. Although the development of new antibiotics has stagnated, various agents with antibacterial properties are currently in clinical and preclinical trials. Non-antibiotic strategies encompass antibiotic potentiators, bacteriophage therapy, antivirulence therapeutics, antimicrobial peptides, antibacterial nanomaterials, host-directed therapy, vaccines, antibodies, plant-based products, repurposed drugs, as well as their combinations, including those used alongside antibiotics. Significant challenges exist in developing new antimicrobials, particularly related to scientific and technical issues, along with policy and economic factors. Currently, most of the alternative options are not part of routine treatment protocols. Conclusions and Future Directions: There is an urgent need to expedite the development of new strategies for treating infections caused by MDR bacteria. This requires a multidisciplinary approach that involves collaboration across research, healthcare, and regulatory bodies. Suggested approaches are crucial for addressing this challenge and should be backed by rational antibiotic use, enhanced infection control practices, and improved surveillance systems for emerging pathogens.M214.322114
Green solution for lead pollution: phytoremediation with Festuca rubra and brushite-aluminosilicate geopolymer material
No full textM221.611
Rare earth elements and health risk assessment of road dust from the vicinity of coal fired thermal power plants
No full textAs emerging pollutants, rare earth elements (REEs) have been explored in different environmental samples. This is the first study to use road dust samples to monitor REEs form the vicinity of thermal power plant (TPPs). Road dust samples were collected from 17 locations (main and side roads) in a 15 km radius surrounding two coal-fired TPP (TPP Kostolac A & B, Serbia). Concentrations of nine REEs (Sc, La, Ce, Nd, Sm, Eu, Tb, Dy, Yb) were measured in the road dust samples (f < 63 μm, easily resuspended fraction size) using instrumental neutron activation analysis (INAA). We have found that the concentrations of REEs do not depend on the distance of the sampling location from TPP. There were no statistically significant differences between the main road and side road samples suggest that traffic is not the main source of REE in the studied area. Principal component analysis, hierarchical cluster analysis as well as geo-accumulation index (Igeo) and enrichment factors (EF) point to an enrichment with Dy of road dust samples collected in September. The road dust samples do not pose any harm to human health in the tested area, as shown by a hazard index of less than 0.1. Despite the low REE risk, it is important to consider the possibility of negative health consequences, mainly because these samples may contain numerous other organic and inorganic pollutants.M218.114432937
COMPARATIVE MORPHOLOGY OF THE VULVAE IN THE FAMILY ANTHROLEUCOSOMATIDAE (DIPLOPODA: CHORDEUMATIDA)
No full textStr.90M3
Soil-dwelling Bacillus velezensis SS-38.4 efficiently colonizes sugar beet phyllosphere and controls phytopathogenic Pseudomonas syringae
No full textBeneficial plant-associated Bacillus species are widely explored and appreciated as eco- and environmental-friendly plant growth-promoting and biocontrol agents but often fall short of achieving the desired effect in plants. In terms of crop protection, Bacillus spp. have been repeatedly scrutinized for their secondary metabolites involved in direct antimicrobial activity towards phytopathogens or inducing systemic resistance in host plants. However, integral aspects of successful implementation of a biocontrol agent, the pronounced colonization capacity and adaptability to variations in abiotic and biotic parameters of a new environment, have been underestimated and underexplored. Here, we demonstrate that the soil-dwelling Bacillus velezensis SS-38.4 can successfully colonize the sugar beet phyllosphere, establish a stable and persistent population owing to its superior motility, ability of surfactin and biofilm production, supported by findings of genome analysis, achieving efficient suppression of the bacterial leaf spot disease. In the phyllosphere, B. velezensis SS-38.4 appears to employ an offensive strategy initiated by a swift invasion of a nonnative niche, reinforced by iron depletion and a wide arsenal of antimicrobials directed towards the phytopathogen. By displaying competitive behavior beyond its original ecological niche, B. velezensis SS-38.4 has exhibited its resilience and versatility in a challenging environment, reflecting its suitability for implementation as a biocontrol agent for efficient and comprehensive crop protection.M213.97
New records and noteworthy data of plants, algae and fungi in SE Europe and adjacent regions, 23
No full textThis paper presents new records and noteworthy data on the following taxa in SE Europe and adjacent regions: green alga Cosmarium crenulatum, fungi Calvatia fragilis, Hypoxylon fuscum, Myriostoma coliforme and Zeus olympius, mosses Antitrichia curtipendula, Buxbaumia viridis, Homalothecium meridionale, Physcomitrium arenicola, Sphagnum inundatum and Syntrichia calcicola, monocots Anacamptis × nicodemi nothosubsp. nicodemi, Ornithogalum montanum and Parapholis incurva and dicots Cardamine waldsteinii and Suaeda salsa.M2230932749
Preliminary data on lampenflora and associated organisms in Gornja Baraćeva Cave (Rakovica, Croatia)
No full textM3
Metal exclusion and physiological plasticity shape orchid success across diverse geologies
No full textBook of Abstracts, Belgrade, Serbia, p.100M3