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Guide to the Winston F. Bolton Papers
Get PDFThe core of this collection comprises the literary works of Winston F. Bolton, encompassing poetry and short stories crafted over a span of six decades. Additionally, Bolton\u27s repertoire extends to the creation of short scripts for skits, plays, and screenplays. Intertwined within this collection are letters exchanged between Bolton and his longtime companion, Faye George, including a jointly authored letter addressed to President Ronald Reagan. An equally substantial component of this series comprises Bolton\u27s ideological essays, delving into significant social, Finding Aid: Winston F. Bolton Papers (MSS-056) 3 Maxwell Library Bridgewater State University / 10 Shaw Road / Bridgewater MA 02325 [email protected] / 508-531-1389 cultural, and philosophical themes that deeply resonated with him. Moreover, the collection offers insight into Bolton\u27s personal narrative through thirty years\u27 worth of journal entries
Probing the Interactions of Anticancer Drug Doxorubicin to DNA Using Optical Tweezers
Get PDFDoxorubicin (Doxo) is a historically significant anti-cancer drug that has been used to treat multiple types of cancers for half a century. The drug targets DNA of cancer cells through a binding mode called intercalation, acting as roadblock during DNA replication to stop tumor formation. While Doxo has been extensively studied through traditional methods, only a handful of research has utilized single molecule methods, which can provide new insights at the molecular level. In this study, we used dual beam optical tweezers to isolate single DNA molecules and mechanically manipulate the DNA in the presence of Doxo. We conducted two types of experiments: slow stretching experiments and constant force experiments. In the slow stretching experiments, we allowed time for Doxo to reach binding equilibrium by pausing after each step while stretching the DNA. In the constant force experiments, we held the DNA at constant tension and measured the extension as a function of time. The equilibrium extensions of the DNA upon binding to Doxo were used, along with a one-dimensional binding model, to find how strongly the drug binds to DNA (the binding affinity) at various forces. Although we performed only one set of constant force experiments at 20pN, we validated that the equilibrium extensions upon binding to Doxo and the binding affinity from both experiments matched within uncertainty. Quantifying the results provided us with an equilibrium extension of DNA upon an intercalation event to be 0.20±0.03 nm. The optical tweezers experiment revealed a nano molar binding affinity of 57±12 nM in contrast to micromolar affinitiesreported in the literature. These results could be very beneficial to not only reduce the dosage and the side effects of Doxo but also to the development of better anti-cancer drugs in the future
Computing an Image of Objects Hiding Behind a Black Hole
Get PDFGravitational lensing is the bending of light rays around a black hole. The goal of this project was to produce a computer code that would model light rays coming from a grid of objects set behind a rotating black hole. Using these light rays, we produced an image illustrating how this background of objects would appear to an observer on Earth. This was done by creating a MATLAB code to model the paths of multiple light rays at a time. This code was then used to help check and correct a C++ code that produced an image. Over the semester, we have worked to successfully increase the accuracy of the final image by fine-tuning our C++ code
The Effectiveness of the Chinese Communist Party’s Guerrilla Warfare during the Second Sino Japanese War, 1937-1945
Get PDFDuring the Second Sino-Japanese War, the Chinese Communist Party prioritized preserving widespread support while inflicting significant damage on Japanese forces despite facing formidable opposition, leading to the development of specific strategies to meet these goals. Ultimately, the Communists’ adoption of guerrilla warfare became the hallmark of their strategy, influencing the post-war perception of Communist success versus Nationalist failure. Extensive research has revealed that the Communists’ guerrilla warfare was overall highly successful, soundly developed, and instrumental in achieving China’s victory over Japan, due to strategies that had proven to have little recourse in combat
Student Attitude about School Resource Officers
Get PDFMaintaining safety is a goal that has remained steady in the United States education system\u27s history (Kober, 2020). Throughout changes in society, such as the increase of drug and alcohol crimes, school shootings, and the COVID-19 pandemic, the safety of youth has become a main priority and changes to the education system have adapted to such changes to ensure safety. The topic of student perception on school safety and the role of school security measures is also important. While students are directly impacted by security measures put into place, they are the best source of data to receive feedback about their effectiveness
Social Media’s Impact on Journalism and News: NBCUniversal\u27s Strategies and Utilization
Get PDFAs NBCUniversal has traditional roots in the broadcasting industry, it must evolve and adapt to stay relevant and popular among newer generations. To do so, NBCU must utilize social media. The purpose of this case study is to analyze NBCU’s social media methods to identify what strategies are effective for themselves and others in the journalism industry