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    662 research outputs found

    Green Nanomaterials: Processing, Characterization and Applications

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    This chapter presents an introduction to green nanomaterials, synthesized by green approach. Brief methods of green nanomaterials processing, advantages of green processing and their limitations are discussed. The different types of green nanomaterials with their processing methods are explored. This chapter also provides an information on how the green nanomaterials are characterized and advanced methods of characterizing equipments are reviewed. Furthermore, various applications of green nanomaterials are detailed

    Nanomaterials Based Polymer Composites: Mechanical Properties

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    The advancements of nanomaterials and polymer nanocomposites have been an area of hot issues in most recent times. This is due to the unique mechanical features possessed by nanomaterials and polymer nanocomposites. The unique mechanical performance of those materials includes but is not limited to tensile strength, abrasion resistance, bending resistance (stiffness), toughness, superior flexibility, compactness and high resistance against harsh environments. Nanomaterials also show special possibilities to form a matrix with polymers to form polymer nanocomposites which further creates an advantage to get the desired properties for unique applications. This chapter aims to review the mechanics of nanomaterials and polymer nanocomposites and the basic results obtained in this aspect. First, the main concept of nanomaterials and polymer nanocomposites will be presented. Furthermore, the basics of nanomaterials and polymer nanocomposites will be discussed. Finally, detailed mechanics of both nanomaterials and polymer nanocomposites will be highlighted. The review result indicated that nanomaterials and polymer nanocomposites are emerged as promising materials to be applied in different applications fields

    LAVA: Log Authentication and Verification Algorithm

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    Log files provide essential information regarding the actions of processes in critical computer systems. If an attacker modifies log entries, then critical digital evidence is lost. Therefore, many algorithms for secure logging have been devised, each achieving different security goals under different assumptions. We analyze these algorithms and identify their essential security features. Within a common system and attacker model, we integrate these algorithms into a single (parameterizable) “meta” algorithm called LAVA that possesses the union of the security features and can be parameterized to yield the security features of former algorithms. We present a security and efficiency analysis and provide a Python module that can be used to provide secure logging for forensics and incident response

    Update on Toxicological and Safety Pharmacological Profiling of the Anti-Infective and Anti-Inflammatory Peptide Pep19-2.5

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    Aspidasept (Pep19-2.5) and its derivative Pep19-4LF (“Aspidasept II”) are anti-infective and an-ti-inflammatory synthetic polypeptides currently in development for application against a variety of moderate to severe bacterial infections. Such severe infections could lead to systemic inflam-mation, as in the case of severe sepsis and septic shock. In addition, development as application against non-systemic diseases in the case of skin and soft tissue infections (SSTI) is ongoing. In the present study, Aspidasept and Aspidasept II and their part structures were analysed with respect to their toxic behavior in different established models against a variety of relevant cells, and in electrophysiological experiments targeting the hERG channel according to ICH S7B. Furthermore, the effects in mouse models of neurobiological behavior and the local lymph node according to OECD test guideline 429 were investigated, as well as a rat model of repeated dose toxicology according to ICH M3. The data provide conclusive information about potential toxic effects, thus specifying a therapeutic window for the application of the peptides. Therefore, these data allow us to define Aspidasept concentrations for their use in clinical studies as parenteral application

    Aseptische Herstellung steriler Arzneimittel

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    Wenn eine terminale Sterilisation nicht möglich ist, werden sterile Arzneimittel unter aseptischen Bedingungen hergestellt. Hierbei werden zum Schutz des Produkts vielfältige Maßnahmen zur Kontaminationskontrolle kombiniert. Den äußerst hohen Maßstäben an die Produktionsräume, -anlagen und -prozesse wird mit weitreichenden qualitätssichernden Instrumenten begegnet. Dabei ist es besonders wichtig, die Gefahr, die vom größten Kontaminationsfaktor – dem Personal – ausgeht, zu minimieren

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