Repositorio académico de acceso abierto (Univ. Autonóma de Chile)
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Effectiveness and Safety of Different Treatment Modalities for Patients Older Than 60 Years with Distal Radius Fracture: A Network Meta-Analysis of Clinical Trials
No full textThe aim of this study was to compare the clinical effectiveness and complications of different treatment modalities for elderly patients with distal radius fracture (DRF). METHODS: We performed a network meta-analysis (NMA) of randomized clinical trials (RCTs). Eight databases were searched. The eligibility criteria for selecting studies were RCTs that compared different treatment modalities (surgical or nonoperative) in patients older than 60 years with displaced or unstable intra-articular and/or extra-articular DRFs. RESULTS: Twenty-three RCTs met the eligibility criteria (2020 patients). For indirect comparisons, the main findings of the NMA were in volar locking plate (VLP) versus cast immobilization, with the mean differences for the patient-rated wrist evaluation (PRWE) questionnaire at -4.45 points (p < 0.05) and grip strength at 6.11% (p < 0.05). Additionally, VLP showed a lower risk ratio (RR) of minor complications than dorsal plate fixation (RR: 0.02) and bridging external fixation (RR: 0.25). Conversely, VLP and dorsal plate fixation showed higher rates of major complications. CONCLUSIONS: Compared with other treatment modalities, VLP showed statistically significant differences for some functional outcomes; however, most differences were not clinically relevant. For complications, although most differences were not statistically significant, VLP was the treatment modality that reported the lowest rate of minor and overall complications but also showed one of the highest rates of major complications in these patients. PROSPERO Registration: CRD42022315562.Universidad Autónoma de Chil
Statistical Considerations for Analyzing Data Derived from Long Longitudinal Cohort Studies
No full textModern science is frequently based on the exploitation of large volumes of information storage in datasets and involving complex computational architectures. The statistical analyses of these datasets have to cope with specific challenges and frequently involve making informed but arbitrary decisions. Epidemiological papers have to be concise and focused on the underlying clinical or epidemiological results, not reporting the details behind relevant methodological decisions. In this work, we used an analysis of the cardiovascular-related measures tracked in 4–8-year-old children, using data from the INMA-Asturias cohort for illustrating how the decision-making process was performed and its potential impact on the obtained results. We focused on two particular aspects of the problem: how to deal with missing data and which regression model to use to evaluate tracking when there are no defined thresholds to categorize variables into risk groups. As a spoiler, we analyzed the impact on our results of using multiple imputation and the advantage of using quantile regression models in this context. © 2023 by the authors.CIBERESP; Fundación Bancaria Caja de Ahorros de Asturias; Federación Española de Enfermedades Raras, FEDER; Instituto de Salud Carlos III, ISCIII, (PI04/2018, PI09/02311, PI13/02429, PI18/00909); Universidad de OviedoUniversidad Autónoma de Chil
Learning Models for Higher Education in Engineering: Motivation, Self-Determination, and the Role of Information and Communication Technologies
No full textIn the last decade, great strides have been made to increase access to education and enrollment rates at all levels (primary, secondary, and higher education). Actions such as promoting equal access to education, preventing school dropout, and establishing free education, among other actions proposed by organizations such as UNESCO, seek to guarantee the universality of education. This is undoubtedly a great challenge, and to address it, it is necessary to characterize how students face the learning process, considering factors such as autonomy, competencies, and their own basic psychological needs, looking for effective learning models based on students’ needs in a changing world, where ICTs play a relevant role. This research analyzes learning models, motivation, self-determination, and technologies used for learning achievement in higher engineering education. The study will highlight relevant initiatives and the most commonly used technological tools. It will also identify learning models that seek to link emotional intelligence, self-determination, cognitive skills, and ICT. The PRISMA protocol guided the study, finding 132 relevant articles to be analyzed and proposing best practices in using learning models, strategies, and ICT to foster students’ intrinsic motivation. © 2023 by the authors.Universidad de La Frontera, UFRO, (IF21-0006, PEG23-0007)Universidad Autónoma de Chil
Protocolo de Lesión Térmica, para Estudio de Cicatrización, en Modelo Animal Cobayo (Cavia porcellus)
No full textExperimental healing studies in humans are complex and difficult to replicate in vitro. Hence, animal models are needed to study the different stages involved. The guinea pig (Cavia porcellus) is a model close to human physiology, including the lack of vitamin C synthesis, a precursor of collagen fibers for healing. The thermal injury in this animal makes it possible to study all the stages of healing, taking few days to show tissue repair in the processes with and without localized infection. The aim of this work was to systematize an experimental guinea pig (Cavia porcellus) animal model protocol for studies on healing with and without localized infection. © 2023, Universidad de la Frontera. All rights reserved.Universidad Autónoma de Chil
Prevalencia del haplotipo de riesgo GA de los polimorfismos rs1554483 y rs4864548 del gen CLOCK asociados a la obesidad y el sobrepeso en 26 poblaciones
No full textIntroduction: the GA haplotype of polymorphisms rs1554483 and rs4864548 has been associated with components of the metabolic syndrome such as high blood pressure and triglyceride levels; its carriers have a risk of obesity, 1.5 times higher than the rest of the population. Methodology: SNP rs1554483 and rs4864548 were obtained from 2504 individuals from the “1000genomes phase 3” database. Data were grouped into five macro populations (Africa, East Asia, South Asia, Europe and Latin America) covering a total of 26 populations. Differences in haplotype frequency between macro populations and populations were analyzed, for which Fisher’s F statistic was used. Results: the macro population of Africa presented the lowest frequency (17.9 %) and that of East Asia the highest (57.4 %). Within the populations there is a relative homogeneity in the frequencies, except in the case of those that make up the macro population of Latin America where the Peruvian population of Lima and the Puerto Rican population present much higher frequencies than the rest. Conclusions: the GA haplotype presents heterogeneity between macro populations, which suggests highly differentiated micro evolutionary pro-cesses between continents. We propose to study the association of the GA haplotype with other polymorphisms such as rs3749474, rs11932595 and rs6859524 that have also been associated with risk of obesity and factors associated with metabolic syndrome. © Copyright 2023 SENPE y©Arán Ediciones S.L.Universidad Autónoma de Chil
Physical Activity in Immersive Virtual Reality: A Scoping Review
No full textPhysical activity has benefits for health, but many adolescents are inactive. However, video games such as Immersive Virtual Reality (IVR) have grown in popularity as a leisure activity among young people, allowing them to manipulate objects in virtual environments increasing the practice of physical activity. The evidence indicates that the interest in physical activity through IVR is greater than in traditional methods, and different experiences have been reported. However, few studies indicate the sample evaluated, the effects found, or the IVR instruments used. Due to this, is the aim of this study is to identify the publications referring to IVR and physical activity, characterize them, and present the obtained main findings. For this, the guidelines described in the PRISMA-ScR for scoping reviews were applied. After the use of the inclusion and exclusion criteria, eight articles were included. Results show evidence regarding physiological outcomes, perceptual variables, interest and enjoyment, and psychological effects regarding physical activity through IVR. Additionally, the use of different devices and their prescriptions are explored. It is concluded that there is interest from the scientific community for the practice of physical activity through IVR, as well as for its application for the maintenance of active habits. This is important as it positions IVR as a method that can be a more experiential and effective way to develop and maintain a healthy lifestyle. © 2023 by the authors.Universidad Autónoma de Chil
Antioxidant activity and enzymatic of lichen substances: A study based on cyclic voltammetry and theoretical
No full textThe antioxidant activity of nine lichen substances, including methylatrarate (1), methyl haematommate (2), lobaric acid (3), fumarprotocetraric acid (4), sphaerophorin (5), subsphaeric acid (6), diffractaic acid (7), barbatolic acid (8) and salazinic acid (9) has been determined through cyclic voltammetry. The compounds 1–4 presented slopes close to the Nernst constant of 0.059 V, indicating a 2H+/2e− relation between protons and electrons, as long as the compounds 5, 6, 7, 8, and 9 present slopes between 0.037 V and 0.032 V, indicating a 1H+/2e− relation between protons and electrons. These results show a high free radical scavenging activity by means of the release of H+, suggesting an important antioxidant capacity of these molecules. Theoretical calculations of hydrogen bond dissociation enthalpies (BDE), proton affinities (PA), and Proton Transfer (PT) mechanisms, at M06-2x/6-311+G(d,p) level complement the experimental results. Computations support that the best antioxidant activity is obtained for the molecules (3, 4, 5, 6, 7 and 8), that have a carboxylic acid group close to a phenolic hydroxyl group, through hydrogen atomic transfer (HAT) and sequential proton loss electron transfer (SPLET) mechanisms. Additional computations were performed for modelling binding affinity of the lichen substances with CYPs enzymes, mainly CYP1A2, CYP51, and CYP2C9*2 isoforms, showing strong affinity for all the compounds described in this study.Universidad Autónoma de ChileInstituto de Ciencias Biomédica
Irregular migrants' experiences of health disparities while living in informal settlements during the COVID-19 pandemic
No full textAims: The objective of this study was to describe and understand irregular migrants' (IMs') experiences of health disparities while living in informal settlements (ISs) during the COVID-19 pandemic. Design: Qualitative descriptive study. Methods: Thirty-four IMs originating from different African countries living in ISs took part in this study. Data were collected between January and March 2022 through three focus groups and 17 in-depth interviews. Thematic analysis was used to analyse qualitative data with ATLAS.ti computer software. Results: Three main themes emerged: (1) Extreme vulnerability: ISs and abuse; (2) Inequality in health treatment has increased during COVID-19; and (3) The impact of COVID-19 on the health of IMs: help from non-governmental organizations and nurses. Conclusion: Irregular migrants are at a higher risk of exposure to COVID-19 due to their precarious living conditions, administrative situation and access to the health system. It is recommended that specific programmes be strengthened to improve health care for this population. Impact: What problem did the study address? This study examines IMs' experiences of health disparities during the COVID-19 pandemic. What were the main findings? IMs are at higher risk of exposure to COVID-19 due to social, health, housing and work inequalities. Community health nurses alongside non-governmental organizations have facilitated the implementation of measures to protect this population against COVID-19. Where and on whom will the research have an impact? With the aim of improving care for IMs, strategies have been suggested for health institutions to address problems relating to accessing the health system, and to promote networking between non-governmental organizations and community health nurses. © 2023 The Authors. Journal of Advanced Nursing published by John Wiley & Sons Ltd.General Nursing Council of Spain, (PNI_CGE88); UAL‐FEDER, (UAL2020‐CTS‐D2031)Universidad Autónoma de Chil
Towards the Integration of Security Practices in Agile Software Development: A Systematic Mapping Review
No full textSoftware development must be based on more than just the experience and capabilities of your programmers and your team. The importance of obtaining a quality product lies in the risks that can be exploited by software vulnerabilities, which can jeopardize organizational assets, consumer confidence, operations, and a broad spectrum of applications. Several methods, techniques, and models have been suggested and developed to address software security. However, only a few have solid evidence for creating secure software applications. The main objective of this paper is to survey the literature for methods or models suitable for considering the integration of security in all or some of the phases of the software development life cycle and which ones are most considered or neglected. This study represents the beginning of research to generate a methodology that integrates security practices in agile software development, allowing inexperienced developers to create more secure applications. © 2023 by the authors.Fondecyt de Iniciación en investigación; Universidad de La Frontera, UFRO, (11230141, DI22-0043); Agencia Nacional de Investigación y Desarrollo, ANIDUniversidad Autónoma de Chil
Valorization of Wheat Crop Waste in Araucanía, Chile: Development of Prototype of Thermal Insulation Material for Blowing Technique and Geographical Analysis
No full textHouses in the operational stage consume around 40% of the world’s energy, and most of it is consumed by air conditioning. This generates several problems, especially in cities, where biomass combustion is the most widely used form of heating. For this reason, environmental regulation works in parallel with energy efficiency, where efficient and low-impact thermal insulating materials are key to reduce the energy demand and fuel consumption to generate comfort in dwellings. This work considers the valorization of wheat straw from the Araucanía region of Chile, to develop a prototype for a thermal insulating material applied through the blowing technique. The results show the insulation potential of the fiber, which, in post-chopping conditions and at an average density of 80 [kg/m3], has thermal conductivity of 0.034 [W/mK]. This value is much better than that of glass wool and other inorganic materials sold in the Chilean market. In addition, the developed material can be incorporated into partitions using the blowing technique, improving the execution time for the thermal insulation section. Finally, it is indicated that a good option to install a processing plant is in the central valley of the region, specifically in the communes of Victoria and Perquenco. © 2023 by the authors.Universidad Autónoma de Chil