SCTIMST DSpace (Sree Chitra Tirunal Institute for Medical Sciences and Technology)
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Bio-Engineering of a Tracheal Construct-Identification of Appropriate Biomaterial Scaffolds and Conditions
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Solvothermal exfoliation assisted synthesis of transition metal dichalcogenide based tungsten disulphide quantum dots (WS2 QDs) and cellular QD-bio interaction in LN-229 human glioblastoma cells
No full textWS2 is a typical TMDC candidate which marked a great sensation due to its similar characteristics with that of graphene. In the present study, highly cyan green emissive and excellent water dispersive WS2 QDs were prepared via top down strategy by solvothermal liquid exfoliation method using NMP solvent. The optical and physico-chemical characteristics of WS2 QDs was investigated systematically. The resultant WS2 QDs exhibit stable fluorescence (λmax = 500 nm), spherical morphology with a uniform thickness of ∼4nm. Moreover, the synthesised QDs exhibit a size-dependant photoluminescence in the wide visible region. Under 365 nm longer wavelength UV illumination, bright cyan green fluorescence was visualised due to excellent quantum confinement effect. XRD analysis revealed the efficient exfoliation potential of the material via this synthesis route. The as synthesised WS2 QDs exhibits excellent properties such as stable aqueous dispersion, extreme low cytotoxicity as well as photoluminescent properties, which makes them suitable candidates for optoelectronic and biological applications. Cellular interaction mediated cytotoxic response was evaluated by MTT assay in LN-229 human glioblastoma cells with a wide ranging concentrations and confirmed the non-destructive status of these QDs in biological subjects. The results from the study also confirm the potential of WS2 QDs to be used as probes for real-time optical cellular imaging and further in vivo trajectory imaging studies
“Effect of haemoglobin levels on near infrared spectroscopic (nirs) monitoring in cyanotic congenital heart disease patients” -a prospective observational study
No full textA study on post effects of Acute Encephalitis Syndrome (AES) among 1- 15-year old children in Muzaffarpur district.
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Risk factors of non-communicable diseases among the transgender population in Kerala: a cross-sectional study
No full textDevelopment and Evaluation of Expandable Brain Retractor with Tunable Expansion Ratio
No full textThe brain tumor treatment is challenging and requires highly skilled neurosurgeon. These tumors are surgically excised by isolating them from normal tissue using surgical retractors. The retractors provide maximal and safe exposure of the surgical field to the surgeon, which is evolved from the handheld retraction system. The majority of brain surgeries use Leyla and Greenberg retract. This traditional retractor induced ischemia, edema and parenchymal trauma are well known, which result in brain tissue injury in up to 29% of cases. The authors conceptualized a single unit circumferential 360-degree expansion mechanism to reduce brain injuries. Further, the surface area is optimized to keep brain tissue retraction pressure within the limit of Leyla retractor. The design equations are derived for smooth manufacturing and a simple locking mechanism maintains retractor to certain deployed diameter in a stable and steady manner. The device is prototyped, and the concept is verified against analytical models. It is conceived as a cost-effective, efficient, and easily manufacturable concept using design equations. The findings demonstrate the advantage of the proposed retractor over existing retractors. The retractor aims to provide optimal retraction pressure, facile handling, universal size, and workspace between the retractor flanges. Its applications may also extend to other surgical specialities and visceral organ sites
Optically Clear Silk Fibroin Films with Tunable Properties for Potential Corneal Tissue Engineering Applications: A Process–Property–Function Relationship Study
No full textOwing to the shortage of donor corneas and issues associated with conventional corneal transplantation, corneal tissue engineering has emerged as a promising therapeutic alternative. Biocompatibility and other attractive features make silk fibroin a biomaterial of choice for corneal tissue engineering applications. The current study presents three modes of silk fibroin film fabrication by solvent casting with popular solvents, viz. aqueous (aq), formic acid (FA), and hexafluoroisopropanol (HFIP), followed by three standard modes of postfabrication annealing with water vapor, methanol vapor, and steam, and systematic characterization studies including corneal cell culture in vitro. The results indicated that silk fibroin films made from aq, FA, and HFIP solvents had surface roughness (Rq) of 1.39, 0.32, and 0.13, contact angles of 73°, 85°, and 89°, water uptake% of 58, 29, and 27%, swelling ratios of 1.58, 1.3, and 1.28, and water vapor transmission% of 39, 26, and 22%, respectively. The degradation rate was in the order of aq > HF > FA, whereas the tensile strength was in the order of aq 90% transmission in the visible range, irrespective of fabrication and postfabrication processing conditions. The films were noncytotoxic against L929 cells and were cytocompatible with rabbit cornea-derived SIRC cells in vitro. The study demonstrated the potential of fine-tuning various properties of silk fibroin films by varying the fabrication and postfabrication processing conditions
