SCTIMST DSpace (Sree Chitra Tirunal Institute for Medical Sciences and Technology)
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Toxicology: Interaction of brain astrocytes with Zinc oxide nanoparticles (ZnO NPs) and related inflammatory, immuno and neurotoxicological response using rat model
No full text2D materials for next generation healthcare applications
No full text2 dimensional (2D) materials are budding new class of materials with exciting potential in optical, electrical, chemical and biomedical applications. Inspired by the attractive properties of graphene attributing to its 2D structure has stimulated researchers to hunt for new 2D materials. Unique characteristics like high surface-volume ratio, shape, surface charge, anisotropic nature and tunable functionalities of 2D structures opens up its application scope further. 2D materials have marked their impact on a wide range of area notably material science, optoelectronics, engineering and biomedical science. Currently, researchers are focusing on developing new 2D materials and functionalizing 2D materials to achieve desired properties. This review underlines the recent renovations done to 2D materials so as improve its functionality and biocompatibility. Growing trend towards exploring the potential of 2D materials for biomedical applications including targeted drug delivery, imaging, photothermal therapy, tissue engineering and regenerative medicine emphasize the need to consider its biosafety. Large surface area of 2D materials increases chances of exposure of these materials towards cells which in turn shoots up the possibility for cellular interactions augmenting chances of potential toxicity. The present review concludes that the 2D materials are promising choice for next generation biomedical device development
Strontium Hydroxyapatite scaffolds engineered with stem cells aid osteointegration and osteogenesis in osteoporotic sheep model.
No full textOsteoporotic fracture healing is an orthopaedic challenge due to excessive bone resorption and impaired
osteogenesis. Majority of currenttreatment strategies focus on regulating bone resorption and the potential
application of Mesenchymal Stem Cells (MSCs) in promoting osteogenesis has not been explored
much. Furthermore, the present study has put forth a novel approach, wherein the synergistic action of
Strontium (Sr) and MSCs in a single implant may facilitate osteoporotic bone healing.
Strontium Hydroxyapatite (SrHA) synthesized by wet precipitation was fabricated into tissue engineered
Strontium incorporated Hydroxyapatite (cSrHA) using sheep adipose tissue derived MSCs
(ADMSCs). Porosity, radiopacity and cytocompatibility of SrHA scaffolds were found appropriate for
orthopaedic applications. cSrHA scaffolds exhibited an in vitro Alkaline Phosphatase activity of 20 mol
pnp/30 min comparable to that of Hydroxyapatite (HA) – control scaffold, proving its osteogenic efficacy.
Implantation studies in sheep osteoporotic model depicted enhanced osteogenic ability with mature
lamellar bone formation in cSrHA implanted group, compared to bare HA, SrHA and tissue engineered HA
implanted groups. Histomorphometry data substantiated improved osteogenesis on par with material
resorption, as cSrHA implanted group exhibited highest regeneration ratio of 0.38 ± 0.05. Density histograms
from micro CT further signified the enhanced osteointegrative ability of cSrHA implants. Results
of the study depicted the therapeutic potential of cSrHA in osteoporotic bone healing and proposes the
use of allogenic ADMSCs for fabricating “Off the Shelf Tissue Engineered Products
A Retrospective Study of Angiogram Negative Subarachnoid Haemorrhage: Assessment of Clinical Profile, Bleeding Pattern and Long-Term Outcomes
No full textCultural adaptation of a peer-led lifestyle intervention program for diabetes prevention in India: the Kerala diabetes prevention program (K-DPP)
No full textBackground: Type 2 diabetes mellitus (T2DM) is now one of the leading causes of disease-related deaths globally.
India has the world’s second largest number of individuals living with diabetes. Lifestyle change has been proven
to be an effective means by which to reduce risk of T2DM and a number of “real world” diabetes prevention trials
have been undertaken in high income countries. However, systematic efforts to adapt such interventions for T2DM
prevention in low- and middle-income countries have been very limited to date. This research-to-action gap is now
widely recognised as a major challenge to the prevention and control of diabetes. Reducing the gap is associated
with reductions in morbidity and mortality and reduced health care costs. The aim of this article is to describe the
adaptation, development and refinement of diabetes prevention programs from the USA, Finland and Australia to
the State of Kerala, India.
Methods: The Kerala Diabetes Prevention Program (K-DPP) was adapted to Kerala, India from evidence-based
lifestyle interventions implemented in high income countries, namely, Finland, United States and Australia. The
adaptation process was undertaken in five phases: 1) needs assessment; 2) formulation of program objectives; 3)
program adaptation and development; 4) piloting of the program and its delivery; and 5) program refinement and
active implementation.
Results: The resulting program, K-DPP, includes four key components: 1) a group-based peer support program for
participants; 2) a peer-leader training and support program for lay people to lead the groups; 3) resource materials;
and 4) strategies to stimulate broader community engagement. The systematic approach to adaptation was
underpinned by evidence-based behavior change techniques.
Conclusion: K-DPP is the first well evaluated community-based, peer-led diabetes prevention program in India. Future
refinement and utilization of this approach will promote translation of K-DPP to other contexts and population groups
within India as well as other low- and middle-income countries. This same approach could also be applied
more broadly to enable the translation of effective non-communicable disease prevention programs developed in
high-income settings to create context-specific evidence in rapidly developing low- and middle-income countries.
Trial registration: Australia and New Zealand Clinical Trials Registry: ACTRN12611000262909. Registered 10 March 201
PROGRESSION OF AORTIC REGURGITATION IN PATIENTS WITH SUB-AORTIC AND SUBPULMONARY VENTRICULAR SEPTAL DEFECT AND AORTIC REGURGITATION AFTER SURGICAL CLOSURE: LONG TERM FOLLOW UP
No full textA PROSPECTIVE STUDY TO PREDICT APPROPRIATE UNCUFFED ENDOTRACHEAL TUBE SIZE BY ULTRASONOGRAPHY IN PEDIATRIC PATIENTS UNDERGOING CARDIAC SURGERY UNDER GENERAL ANAESTHESIA
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