SCTIMST DSpace (Sree Chitra Tirunal Institute for Medical Sciences and Technology)
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Outcome of medically managed uncomplicated acute type b aortic dissection- a single center retrospective analysis
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Evaluation of transcranial doppler spectral (tcd) signatures and assessment of cerebral oxygenation using near-infrared spectroscopy (nirs) in patients undergoing neurosurgical procedures as a novel marker for clinical outcome and prognostication - an observational study
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Assessment of Inflammatory Response on Pyrogenic Induction by In vitro and In vivo Methods
No full textAutologous versus allogeneic blood transfusion: a comparative study of the peri-operative outcomes in a tertiary care hospital in South India
No full textEvaluating the role of synthetic magnetic resonance imaging (mri) in differentiating active and chronic multiple sclerosis (ms) plaques on the basis of quantitative parameters namely t1 relaxation rate (r1), t2 relaxation rate (r2), proton density (pd) and myelin water fraction (mwf)
No full textA study on predictors of outcome and recurrence risk in embolic stroke of undetermined source
No full text. Exploring the Potential of Alginate-Gelatin-Diethylaminoethyl Cellulose Fibrinogen based Bioink for 3D Bioprinting of Skin
No full textDesigning printable bioinks for 3D bioprinting capable of supporting cellular viability with post-printing functionality remains challenging. Native ECM offers several physical, chemical, and biological cues that are difficult to restore using only a single component. Herein, we have optimized a multicomponent-based bioink formulation comprising alginate (ALG), gelatin (GEL), diethylaminoethyl cellulose (DCEL) and fibrinogen (FIB), termed as ALG-GEL-DCEL-FIB bioink for potential application in bioprinting and biofabrication of skin tissue equivalents. The designed formulation was extensively studied for its printability, physico-chemical, rheological, and biocompatibility properties. Excellent printability, shape fidelity and cell-laden tissue equivalent printing were established using the RegenHu 3D Discovery Bioprinter. The human primary fibroblast and keratinocyte-laden bioprinted constructs exhibited good cell viability. Long term culture of 4 weeks comprising 5 days of air-liquid-interphase followed by 21 days of submerged culture produced biomimetic tissue histology in the ALG-GEL-DCEL-FIB bioink printed constructs. Specific epidermal-dermal marker expressions proving functionality were evident in immunohistochemical, biochemical and gene expression analysis. The ALG-GEL-DCEL-FIB bioink may be explored further for potential biofabrication and therapeutic applications