SCTIMST DSpace (Sree Chitra Tirunal Institute for Medical Sciences and Technology)
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Factors associated with treatment adherence among pulmonary tuberculosis patients in new delhi
No full textBiofabrication of skin tissue constructs using alginate, gelatin and diethylaminoethyl cellulose bioink.
No full textIntroduction: Biofabrication of skin tissue equivalents using 3D bioprinting technology has gained much attention in recent times due to the simplicity, the versatility of the technology and its ability in bioengineering biomimetic tissue histology. The key component being the bioink, several groups are actively working on the development of various bioink formulations for optimal skin tissue construction. Methods: Here, we present alginate (ALG), gelatin (GEL) and diethylaminoethyl cellulose (DCEL) based bioink formulation and its application in bioprinting and biofabrication of skin tissue equivalents. Briefly, DEAE cellulose powder was dispersed in alginate solution with constant stirring at 60 °C to obtain a uniform distribution of cellulose fibers; this was then mixed with GEL solution to prepare the bioink. The formulation was systematically characterized for its morphological, physical, chemical, rheological, biodegradation and biocompatibility properties. The printability, shape fidelity and cell-laden printing were assessed using the CellInk bioprinter. Results: The bioink proved to be a good printable, non-cytotoxic and stable hydrogel formulation. The primary human fibroblast and keratinocyte-loaded 3D bioprinted constructs showed excellent cell viability, collagen synthesis, skin-specific marker and biomimetic tissue histology. Conclusion: The results demonstrated the successful formulation of ALG-GEL-DCEL bioink and its application in the development of human skin tissue equivalents with distinct epidermal-dermal histological features
Role of immunoglobulin and antibodies in disease management
No full textThe immune system is a highly advanced and coordinated mechanism that allows a living organism to distinguish between "self" and "non-self". The host uses both innate and adaptive immune response mechanisms to identify and eliminate pathogenic microorganisms. Human immunoglobulin is the prominently used blood product in the clinical practice. Immunoglobulin applications have improved rapidly due to the exploration of its immunomodulatory and anti-inflammatory properties. This made this blood product into a precious and advanced tool in the treatment of numerous disease conditions which are linked with humoral immune deficiency or that cause immune system dysfunction. Human immunoglobulin (Ig) is used for Ig replacement therapy in both primary and secondary immunodeficiency conditions, for prevention and treatment of certain infections. It also acts as an immunomodulatory agent for autoimmune and inflammatory disorders. Therapeutic antibodies have been successfully used for the treatment of diverse pathological conditions. Drug development programs exclusively select highly specific antibodies that recognize a single disease-associated target. Hopefully this review will give an insight towards the immune system, the involvement of the specialized immune cells, their products and involvement in various immune disorders and pathological conditions
Role of india hypertension control initiative (ihci) on the structure and functions of health system : a study in Thrissur district, Kerala
No full textBiocompatibility of strontium incorporated ceramic coated titanium oxide implant indented for orthopaedic applications
No full textTitanium and its alloys are the most commonly used materials for manufacturing orthopaedicimplants. Various surface modifications are done in titanium alloys to improve osseointegration as well as for long term success of endosseous implants. In the present study preclinical safety evaluation of two nanoporous mixed metal oxide bone implant materials, TiO2-Nb2O5 (TN) and Sr-HAP modified TN (TNS) were assessed by in vitro and in vivo methods. The surface morphological analysis of fabricated materials was done by XRD, IR and SEM. The biocompatibility evaluations performed were In vitro cytotoxicity tests using L929 cells, Assessment of hemolytic properties of materials and Test for local effects after implantation in bone as per international standards. The results of the study conclude that the materials, TN and TNS are non-cytotoxic, non-hemolytic and biocompatible and can be used safely for orthopaedic applications
Functional connectivity within language regions in stroke patients with expressive aphasia during real-time functional magnetic resonance-based neurofeedback training
No full textBurden of multi-morbidity in primary care in Kerala: a cross sectional study in family health centres, Malappuram dist., Kerala
No full textValidation of the Malayalam version of the Montreal Cognitive Assessment (MoCA) scale and a prospective evaluation of mild cognitive impairment in Parkinson’s disease using the Malayalam version (“MoCA-M”). (Ref No: 5/4-5/106/Neuro/2013-NCD-1)
No full textBiomedical applications of transition metal dichalcogenides (TMDCs)
No full textTransition metal dichalcogenides (TMDCs) are an emerging class of 2D materials with fascinating properties suitable for various applications that span from material science, electronics, opto-electronics to even biomedical technology. Structurally, TMDCs comprises of a transition metal atom belonging to group 4–7 (Ti, V, Cr, Tc, Hf, Ta, W, Mn, Zr, Nb, Mo, and Re) covalently modified to chalcogens (S, Se, and Te) in a trigonal prismatic orientation. Easiness of exfoliation and possible surface modifications marks the efficacy of these materials for various applications. Even though they are potent candidate materials in electronics and opto-electronics, the recently upgraded biomedical applications sound fascinating with unlimited access. A relatively high photothermal coefficient makes them suitable for dual model cancer therapy. The massive surface area to volume ratio of TMDC nanosheets suggests the suitability for enhanced drug loading and targeted sustainable drug release. Bone regeneration scaffolds made of TMDC compounds showed enhanced mechanical strength, which holds them as promising materials for tissue engineering scaffold designing and 3D printing. Various imaging guided therapies such as PET, SPECT, MRI, CT, and PA imaging are possible without invasive ionizing radiations using TMDC materials. All these existing vast possibilities always left behind the signs of mandatory toxicity profiling. Therefore, with proper safety evaluation and biocompatibility assessment, TMDCs can be suggested as promising materials for various futuristic biomedical applications