SCTIMST DSpace (Sree Chitra Tirunal Institute for Medical Sciences and Technology)
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Poly-L-Lysine modified Iron oxide nanoparticles : Synthesis, characterization and antimicrobial properties
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Design and fabrication of fluorescent probes for biomedical applications: potential tool for in vitro and in vivo bioimaging, sensing and sirna delivery for cancer therapy
No full textVaccine and vaccination as a part of human life: In view of COVID-19
No full textBackground: Vaccination created a great breakthrough toward the improvement to the global health. The development of vaccines and their use made a substantial decrease and control in infectious diseases. The abundance and emergence of new vaccines has facilitated targeting populations to alleviate and eliminate contagious pathogens from their innate reservoir. However, along with the infections like malaria and HIV, effective immunization remains obscure and imparts a great challenge to science.
Purpose and scope: The novel Corona virus SARS-CoV-2 is the reason for the 2019 COVID-19 pandemic in the human global population, in the first half of 2019. The need for establishing a protected and compelling COVID-19 immunization is a global prerequisite to end this pandemic.
Summary and conclusion: The different vaccine technologies like inactivation, attenuation, nucleic acid, viral vector, subunit, and viral particle based techniques are employed to develop a safe and highly efficient vaccine. The progress in vaccine development for SARS-CoV2 is much faster in the history of science. Even though there exist of lot of limitations, continuous efforts has put forward so as to develop highly competent and effective vaccine for many human and animal linked diseases due to its unlimited prospective. This review article focuses on the historical outlook and the development of the vaccine as it is a crucial area of research where the life of the human is saved from various potential diseases
Ultrasound Guided Bilateral Pecto-intercostal Fascial Block: Role as a Preemptive Analgesic Adjunct in Fast-tracking for Mitigating Postoperative Sternotomy Pain
No full textExtracellular matrix-based combination scaffold for guided regeneration of large-area full-thickness rabbit burn wounds upon a single application
No full textRegeneration of large acute and chronic wounds is a concern worldwide. The present study evaluates wound healing competence of a completely human-origin, extracellular matrix (ECM)-based skin substitute/graft. It comprises cell-less amniotic membrane (AM), clinical-grade fibrin (FIB), and hyaluronic acid (HA) termed as AMFIBHA. The use of large-area third-degree rabbit burn wounds evaluated the product efficiency. The AMFIBHA induces hemostasis and permits suture-less positioning on the wound bed. In wet wounds, the AMFIBHA degrades and release biologically active molecules and guide cell migration, proliferation, and regeneration. The study demonstrated the effectiveness of this wound care product in terms of epithelial-dermal regeneration with angiogenesis. The study assessed injury-associated inflammation and different wound healing markers after 28 days of experiment and compared with both positive and negative controls-treated wounds. The regeneration of mature epidermis and dermis with rete pegs and hair follicle-like structure was evident upon a single application. The active involvement of host cells resulted in supple tissue formation. The ECM organization of AMFIBHA-treated tissue resulted in re-gain of mechanical properties comparable to native skin after 56 days. These guided regenerative outcomes reveal a promising translational value of the novel AMFIBHA skin substitute as an off-the-shelf product for clinical use
Electro-clinical and radiological predictors of outcome in super refractory status epilepticus
No full textFactors associated with stroke recurrence, the facilitators and barriers to medication adherence and risk factor control among stroke survivors
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