Institutional Digital Repository (Indian Institute of Technology Kharagpu)

Das, Prasenjit

Theoretical Studies on the Electronic Structure of Molecules and Clusters Having Unusual Bonding Characteristics

H N, Latha

Restoration of a Space-Variantly Blurred Image Using Non-Local Priors

Maharana, Abhishek

Sonocrystallization of Pyrazinamide∶ Multi-Dimensional Population Balance Modelling and Monte-Carlo Simulation

Mondal, Haripriyo

Thesis Abstract 
 
The thesis entitled as, “Design and synthesis of nucleophilic catalysts for 
halofunctionalization based on alpha effect” has been divided into three chapters.  
Keywords: Catalyst design, organo-catalysis, Hydrazide catalyst, alkoxyamide, halogenation, 
alpha effect, nucleophilicity, late-stage chlorination, bromination, dearomative 
bromocyclization, iodination, multihalogenation, peptides, drugs. 
Chapter I portrays a brief outline about the areas which are of relevance in this thesis work, 
such as various modes of halogen activation by nucleophilic catalysis.  
Chapter II describes the development of alkoxyamide catalyst for the activation of N-
bromosuccinimide to perform bromocyclization and bromination of a wide range of substrates 
in a lipophilic solvent. The key feature of the active site is the alkoxy group attached to the 
sulfonamide moiety, which facilitates the acceptance as well as the delivery of bromonium 
species from the bromine source to the substrates.  
Chapter III presents the study of a novel hydrazide based catalyst for late-stage halogenation 
of peptides, drugs and aromatics characterised by high efficiency and selectivity. DFT studies 
indicate that the reaction likely proceeds via a cationic transition state. Also, multihalogenated 
compound could be readily accessed in short times. The protocol shows high functional group 
tolerance and provides a facile route for late-stage functionalization and intermediate for 
further derivatization.  
 


Design and Synthesis of Nucleophilic Catalysts for Halofunctionalization Based on Alpha Effect

Jana, Subhajit

Studies on Two-Dimensional Nanomaterials for Broadband Photodetection with Extended Spectral Coverage

Parveen T, Naseeba

Occurrence, Formation, Human Health Risks, and Phytotoxicity of Disinfection By-Products

B, Abinaya

Purification and Characterisation of Non-Digestible Oligosaccharides Derived from Extracellular Polysaccharide of Antarctic Fungus Thelebolus sp. IITKGP-BT12

Harishma, Boyapally

Design and Analysis of Secured Protocols using Hardware Intrinsic Primitives

Basak, Shreyashi

Adaptive Inference Procedures for Directional Distributions

Bera, Sutanu

Learning Deep Feature Representation of Low Dose Computed Tomography Images for Restoration and Enhancement

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