Institutional Digital Repository (Indian Institute of Technology Kharagpu)

Hazra, Rima

Understanding Dependencies in Bibliographic and Software Systems

Biswas, Ishita

Multiport Converter Topologies for DC Microgrid-Analysis, Design and Control

Kumar, Abhay

Implication of Filled Elastomer Network on Elasticity, Viscoelasticity and Plasticity

Patidar, Sonu Kumar

Combustion, Performance and Emission Characteristics of a Direct Injection Diesel Engine Fueled With Preheated Nano-Oxide Added Straight Vegetable Oil

Sahoo, Rajkumar

Abstract 
   
Thesis Title: Synthetic Studies towards naturally occurring terpenes Volvalerenol-A 
Hypocoprins A-C & Longifolene 
Abstract: Natural products have played a significant role in human disease therapy and prevention. With 
more than 23,000 known compounds, terpenoids are the largest class of natural products. Terpenoids have 
a wide range of biological activities, including anti-cancer, anti-malaria, anti-inflammation, and anti-
infectious disease properties (viral and bacterial). In 2002, the global sales of terpene-based medications 
were estimated to be around $12 billion. TaxolR, an anticancer medicine, and Artemisinin, an antimalarial 
treatment, are two of the most well-known terpene-based pharmaceuticals. Due to the broad spectrum of 
bioactivity and the architecturally complex structure of these molecules synthetic organic chemist 
community have targeted these molecules for total synthesis and biosynthetic study. 
The thesis briefly describes synthetic studies toward the total synthesis of triterpene Volvalerenol A, 
sesquiterpenes Hypocoprins A-C, and Longifolene. For the synthesis of the said natural products, we have 
adopted PLE-mediated enzymatic asymmetric desymmetrization reaction to construct quaternary 
stereocenter, Keck allylation reaction, Reductive cyclopropane ring-opening reaction, Peterson 
olefination, Olefin ring closing-metathesis, HWE olefination, asymmetric alkyne addition reaction, 
Noyori reduction, asymmetric Simmons-Smith Cyclopropanation reaction, Schwartz reaction, NHK 
reaction, Johnson's orthoester rearrangement etc. 
 
Key Words: Terpenes and terpenoids, Asymmetric synthesis, Synthetic methods, Total synthesis, Ring-
closing metathesis (RCM), Natural products etc. 
The thesis entitled “Synthetic Studies towards naturally occurring terpenes Volvalerenol-A Hypocoprins 
A-C & Longifolene” consists of four parts. Chapter 1 provides a General introduction and synthetic 
background on Terpene and Terpenoid, Chapter 2 involves Synthetic studies towards Volvalerenol-A, 
a Unique Tricyclic Triterpenoid through exploitation of Pseudo C2-Symmetry. Chapter 3 contains 
Synthetic studies towards Hypocoprins A-C. Whereas Chapter 4 provides Synthetic studies towards 
Longifolene. 


Synthetic Studies towards Naturally Occurring Terpenes Volvalerenol-A, Hypocoprins A-C and Longifolene

Rani, Poonam

Dynamic Modeling and Experimental Analysis of Transfer Phenomena in a Solar Dryer Integrated with Finned Collector for Processing Pineapple Slices

Sharma, Narayan

Stochastic Dynamic Aeroelastic Analysis of Smart Delaminated Variable Angle Tow Composite Structures

Ghosh, Sanhita

Radiative Perturbation and Health Impact Due to Black Carbon Aerosols over the Indian Subcontinent

Guru, Soumya Ranjan

On the Surface Micro-Mechanical Properties of Polymers

Das, Souvik

Data-Driven Modeling of Cognitive Workload Using Eye Tracking Metrics

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