Open Research Oklahoma (Oklahoma State Univ.)
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Basic guide to understanding the agricultural cooperative system in the U.S. and Oklahoma
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Marketing institutions for fruits and vegetables a bibliography of selected current literature
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UV-treatment of contaminants of emerging concern in wastewater
No full textEvaluation of UV and UV/H2O2 Advanced Oxidation Processes for the Degradation of Macrolide Antibiotics in Wastewater.
Antibiotic contamination in wastewater is a critical environmental and public health concern due to its role in promoting antimicrobial resistance (AMR). Macrolide antibiotics, including azithromycin and gamithromycin, are widely used in human medicine and animal agriculture but persist in aquatic environments because conventional treatment processes often fail to fully degrade them. This study evaluated the effectiveness of ultraviolet (UV) irradiation and UV/H2O2 advanced oxidation processes (AOPs) for the degradation of these compounds.
Experiments were conducted using a 254 nm UV reactor, with degradation quantified through liquid chromatography–tandem mass spectrometry (LC–MS/MS). Initial results for azithromycin demonstrated that direct photolysis was insufficient; at a UV fluence of 96660 mj/cm2, less than 10% degradation was observed with a direct photodegradation rate constant (k) of 2.87E-05 S-1. This indicates that UV alone is ineffective for macrolide removal.
However, the addition of H2O2 at concentrations of 1 and 2 mM significantly enhanced degradation through the production of hydroxyl radicals (.OH). The study specifically examined the impact of water chemistry by testing three pH levels (4, 7, and 10). The pseudo-first-order rate constant (kobs) increased from 2.73E-4 to 4.55E-4 S-1 as H2O2 concentration increased from 0.3mM to 2mM. Notably, the degradation was most efficient at pH 10, where the rate constant reached 4.55E-4 S-1.
Ongoing research is applying these optimized conditions to gamithromycin, a potent antibiotic used extensively in veterinary medicine, to assess its comparative degradability and behavior in agricultural runoff. This research provides a scalable, kinetically-defined treatment strategy to mitigate the spread of antibiotics and improve environmental outcomes in both municipal and agricultural sectors.Robert E. McNair Post-Baccalaureate Achievement ProgramNiblack Research Scholars ProgramCherokee Nation Volunteer ScholarshipPresidential Leadership CouncilBiosystems Engineerin
