University of the Sunshine Coast
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Topical application of temperature-sensitive caerin 1.1 and 1.9 gel inhibits TC-1 tumor growth in mice
No full textGenital warts, which are one of the most common sexually transmitted diseases (STDs), result from persistent infection with human papillomavirus (HPV), especially subtypes 6 or 11. Topical application of 5% imiquimod cream is currently recommended as a first-line treatment choice for genital warts, but the clearance and patient compliance rates remain less than sufficient. In the current study, we developed a temperature-sensitive gel that contains the host-defense peptides caerin 1.1 and 1.9, which were originally isolated from Australian tree frogs of the genus Litoria. Growth of HPV16 E6/E7-transformed TC-1 cells was inhibited in vitro and in vivo following injection of the tumor with the caerin gel in a TC-1 tumor mouse model. Furthermore, when the caerin gel was topically applied, the inhibitory effect remained, and T, NK cells were attracted to the tumor site. In addition, the gel maintained a similar level of bioactivity after incubation at room temperature for 30 days. Our results suggest that this caerin gel, following further optimization, may provide an alternative method for the management of genital warts
Past behaviours and future intentions: An examination of perceptual deterrence and alcohol consumption upon a range of drink driving events
No full textIntroduction:
The threat of application of legal sanctions remains the prominent approach to reduce the prevalence of drink driving in a vast array of motoring jurisdictions. However, ongoing questions remain regarding: (a) the extent that such mechanisms impact upon offending behaviours, (b) the deleterious effect alcohol consumption has on decisions to drink and drive and (c) how best to operationalise (and measure) the concept of drink driving to enhance the accurate measurement of the dependent variable.
Method:
This paper reports on an examination of 773 Queensland motorists' (across nine local government areas) perceptions of both legal and non-legal drink driving sanctions (as well as alcohol consumption) in order to gauge the deterrent impact upon a range of measures of drink driving: the driver thinking they are over the limit, the driver knowing they are over the limit, attempts to evade random breath testing, and intentions to re-offend. The sample completed an online or paper version of the questionnaire.
Results:
The majority of participants reported “never” engaging in “possible” (74.5 %) or “acknowledged” (83.4 %) drink driving events, although a considerable proportion of the sample reported engaging in “possible” (25.5 %) or “acknowledged” (16.6 %) drink driving and attempting to evade RBT (18 %) events, as well as possible intentions to drink and drive in the future (22 %). Males were more likely to report such events. Perceptions of both legal sanctions (certainty, severity and swiftness) as well as non-legal sanctions (fear of social, internal or physical harm) were relatively high and consistent with previous research. Interestingly, non-legal sanctions were reported as stronger deterrents than legal sanctions. However, multivariate analysis revealed that legal deterrents had limited utility predicting offending behaviours, but rather, demographic characteristics (e.g., younger motorists, males) as well as risky drinking behaviour were better predictors. In regards to intentions to offend, a past conviction for drink driving was also a predictor of re-offending.
Practical applications:
These results highlight the ongoing challenges of addressing the problem of drink driving and that some motorists: (a) have entrenched behaviour and/or (b) make the decision to drink and drive before they are under the influence of alcohol
Community engagement is .. : revisiting Boyer's model of scholarship
No full textCriticisms have been levelled at academics at a time when funding of universities is increasingly tied to private and corporate purposes and when academics are held accountable through a hierarchy of functions. Claims are also made that academics work within narrow specializations and are removed from real-world experience and problems. Boyer's model of scholarship offers four categories of scholarship that remain relevant to understanding and guiding the work of academics, including how they engage with communities. To explore the nature of academics' work, we draw on data provided by a group of academics who participated in a research project using both sociological elicitation and visual arts-based research methodologies. The participants were asked to explore what various aspects of current academic work mean for them by providing an image and text, akin to creating a postcard. In this article, we focus on responses they provided to the prompt 'Community engagement is horizontal ellipsis ' The postcards show how community engagement can be interpreted in diverse ways and that, along with teaching and research, community engagement are all integrated, mutually reinforcing drivers and outcomes of academic work
Generalized joint hypermobility in siblings with anteriorcruciate ligament injuries and matched unrelated healthy siblings
No full textBackground and Purpose:
Anterior cruciate ligament (ACL) ruptures are common knee injuries, and siblings of individuals with an ACL injury may be at higher risk of ACL injury. Generalized hypermobility may be a familial factor predisposing siblings to ACL injury and may also relate to faulty lower limb alignment. There is a need to determine whether the interaction between hypermobility, family history, and faulty alignment makes siblings with hypermobility at higher risk for ACL injury so that appropriate preventative measures can be taken. This study therefore aimed to (a) compare the prevalence of generalized hypermobility and faulty limb alignment in siblings with and without injury and (b) assess the relationship between generalized hypermobility and lower limb alignment.
Methods:
In this case‐controlled study, 24 siblings with ACL injuries from 10 families were matched with 24 healthy uninjured siblings from 10 unrelated families. Generalized hypermobility was assessed using Beighton's criteria. Chi‐square analyses compared generalized hypermobility and lower limb alignment between siblings and sibling pairs with and without injuries. Spearman's rho was used to assess correlations between generalized hypermobility and lower limb alignment.
Results:
There were significant differences between the number of injured and uninjured siblings demonstrating generalized hypermobility when tallied individually (p = .003) and in same‐family sibling pairs (p = .019). Significant (or close) differences were found between siblings for knee hyperextension (p < .001), knee valgus (p = .01), and foot pronation (p = .002) and for sibling pairs sharing knee hyperextension (p < .001), knee valgus (p = .06), and foot pronation (p = .06). Generalized hypermobility correlated with knee hyperextension (rs = .722; p < .001), knee valgus (rs = .385; p = .007), and foot pronation (rs = .328; p = .023).
Conclusions:
Generalized hypermobility and faulty limb alignment occur significantly more frequently in injured than uninjured families. Screening for both features would assist in identifying at‐risk siblings. Prevention programmes reduce ACL injuries by 50–70% and should target hypermobile siblings of the ACL injured
Perceived health benefits of higher education for ageing Australian baby boomers
No full textAustralia, as with many other countries, is experiencing a demographic change to an older population structure. It has been forecast that ageing baby boomers will have a substantial impact on long-term health and care costs. The primary aims of this research project were to explore baby boomers' perceived health benefits, motivators and cost of later life university engagement as well as barriers to such engagement, to determine how baby boomers define healthy ageing and quality of life; and to assess if later life university engagement could have a beneficial impact for future health promoting initiatives for this influential cohort and, as a consequence, potential savings on health expenditure.Submitted in the fulfilment of the requirements of the degree of Doctor of Philosophy, University of the Sunshine Coast, 2020
Measurements of subnanometric shifts in lattice parameters due to residual stress in self-piercing riveting (SPR) joint
No full textNo abstract available
Expanding the molecular computing tool-kit: iteration, smart biosensing, small molecule detection, and in vivo therapeutics
No full textNo abstract available
Hybrid grouper in Vietnamese aquaculture: production approaches and profitability of a promising new crop
No full textGrouper aquaculture is a rapidly growing and dynamic industry within Vietnamese aquaculture and an important source of local employment and income generation. Information on the state of current production practices and profitability for specific crops across different geographic locations and stages of production is difficult to obtain. This research contributes to wider efforts to address this knowledge gap by providing indicative findings on current market characteristics, production practice, and profitability of a ‘new’ aquaculture crop in Vietnam: Hybrid grouper (E. lanceolatus X E. fuscoguttatus). Participants in the study identified Hybrid grouper as the most important crop for grow out farms and the second most important crop for nursery farms due to strong market demand and sales prices, fast growth rate, and higher survival compared to other grouper crops. Research utilised a survey of 12 grouper farms in the Northern (Hai Phong) and Central (Khanh Hoa) provinces of Vietnam in mid-2018 to determine indicative financial production characteristics and gross margins (annual net sales revenue minus cost of goods sold) of nursery, cage, and pond enterprises that currently culture Hybrid grouper. Farmers indicated that the Hybrid grouper industry was segmented into three distinct phases of production: spawning, larval rearing and grow out. Few grouper farmers specialise in more than one area. Farmers in both study regions reported that Hybrid grouper were desirable due to the strong market demand and high sale prices, fast growth rate, and higher survival compared to other grouper crops. Farms had different economic characteristics between region and type, major differences were seen in the species cultured, number of people employed and age of farms. All farms interviewed generated annual net sales revenue exceeded the cost of goods sold. Earthen pond farms in Central Vietnam generated a median gross margin of US 8059, and Northern Sea cage farms US 7.7–9.6/kg (adjusted to 2019 US 9–15/kg. The findings indicate that the most significant constraints to the growth and diversification of the grouper aquaculture industry in Vietnam are the limited availability of Hybrid fingerlings due to difficulties in larval rearing, and increases in feed costs due to a lack of domestic feed suppliers. Notwithstanding these constraints, the higher gross margins of Hybrid grouper relative to other financially viable grouper crops suggests continued, albeit moderated, growth of grouper aquaculture in Vietnam
Transient Cerebral Blood Flow Responses During Microgravity
No full textPurpose: A number of studies has well described central cardiovascular changes caused by changing gravity levels as they occur e.g. during parabolic flight. limited data exists describing the effect of microgravity on the cerebrovascular system and brain perfusion. Methods: In this study middle cerebral artery velocity (MCAv) of 16 participants was continuously monitored on a second-by-second basis during 15 consecutive parabolas (1G, 1,8G, 0G, 1,8G) using doppler ultrasound. Simultaneously central cardiovascular parameters (heart rate, mean arterial blood pressure, cardiac output) were assessed. Results: Results revealed an immediate reaction of central cardiovascular parameters to changed gravity levels. In contrast, changes in MCAv only initially were in accordance with a normal cerebral autoregulation. Whereas all of the measured central cardiovascular parameters seemed to have reached a steady state after approximately 8 seconds of microgravity, MCAv, after an initial decrease with the onset of microgravity, increased again during the second half of the microgravity phase. Conclusion: It is concluded that this increase in MCAv during the second half of the microgravity period reflects a decrease of cerebrovascular resistance caused by a pressure driven increased venous outflow and/or a contraction of precapillary sphincters in order to avoid hyperperfusion of the brain