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Cooperation in intercultural crisis and conflict environments research
No full textThis research investigates (RQ#1) how cooperation can emerge in intercultural crisis and conflict environments. It develops and applies the ECOOPx, a six-dimensional framework to analyze cooperation dynamics across diverse crisis stages. Through a mixed-methods approach and multi-scenario case studies in international politics, business, education, and society, the study identifies both readiness and resistance patterns shaping cooperation outcomes.
Key findings highlight the decisive role of relational dimensions in sustaining long-term cooperation, the strengthening effect of early conflict resolution, the importance of collective memory and early crisis detection, and the positive contribution of cultural diversity, which enhances creativity and problem-solving despite generating leadership tensions.
This is an ongoing and open-ended research project that engages with increasingly complex realities, continuously deepening and expanding its conclusions while examining the transformational changes that define our times
Reflexions entorn de la productivitat de l'economia
No full textEn aquest text pretenc reflexionar sobre diversos aspectes que afecten el concepte de productivitat i a la seva mesura. Utilitzaré un to de prescripció de política econòmica, remetent al lector a la bibliografia extensa disponible sobre el tema
Històries d'èxit de la ciència oberta: Blanca Arias
No full textLa professora Blanca Arias comparteix les seves experiències, reflexions i recomanacions sobre ciència oberta. Aquest vídeo forma part de la sèrie de vídeos curts Històries d'èxit de la ciència oberta dirigits a promocionar la ciència oberta a la universita
The relationship between confidence and gaze-at-nothing oculomotor dynamics during decision-making
No full textHow does confidence relate to oculomotor dynamics during decision-making? Do oculomotor dynamics reflect deliberation and the buildup of confidence in the absence of visual stimuli? Here we examine the hypothesis that working memory, deliberation, and confidence warp oculomotor dynamics, both in the presence and absence of visual stimuli. We analyzed oculomotor dynamics in a decision-making task in which participants were provided with an abstract context in which to make the decision, and two similar option images which became eventually invisible. We show that fixations between the empty locations in which the images were formerly shown continued after the options disappeared, consistently with a sustained deliberative process facilitated by oculomotor dynamics. Both, oculomotor dynamics and decision patterns remained unchanged regardless of whether the stimuli were visible. Furthermore, our analyses show that the number of alternating fixations between stimuli correlated negatively with the confidence reported after each decision, while the observation time of the selected target correlated positively. Given that decisions in our experimental paradigm are reported in the absence of the stimuli, this suggests a relationship between evidence retrieval from working memory, confidence gathering and oculomotor dynamics. Finally, we performed a model comparison based on predictions from drift-diffusion models to assess the relationship between sequential fixations between images, deliberation and confidence gathering, and the ensuing choice. These analyses supported confidence as a contributing cognitive process encompassing serial evidence-gathering and parallel option consideration during decision-making
The FLARE score and circulating neutrophils in patients with cancer and COVID-19 disease
No full textPurpose: Inflammation and neutrophils play a central role in both COVID-19 disease and cancer. We aimed to assess the impact of pre-existing tumor-related inflammation on COVID-19 outcomes in patients with cancer and to elucidate the role of circulating neutrophil subpopulations. Methods: We conducted a multicenter retrospective analysis of 524 patients with cancer and SARS-CoV-2 infection, assessing the relationship between clinical outcomes and circulating inflammatory biomarkers collected before and during COVID-19 infection. Additionally, a single-center prospective cohort study provided data for an exploratory analysis, assessing the immunophenotype of circulating neutrophils and inflammatory cytokines. The primary endpoints were 30-day mortality and the severity of COVID-19 disease. Results: Prior to COVID-19, 25% of patients with cancer exhibited elevated dNLR, which increased to 55% at the time of COVID-19 diagnosis. We developed the FLARE score, incorporating both tumor- and infection-induced inflammation, which categorized patients into four prognostic groups. The poor prognostic group had a 30-day mortality rate of 68%, significantly higher than the 23% in the favorable group (p < 0.0001). This score proved to be an independent predictor of early mortality. This prospective analysis revealed a shift towards immature forms of neutrophils and higher IL-6 levels in patients with cancer and severe COVID-19 infection. Conclusions: A pre-existing tumor-induced pro-inflammatory state significantly impacts COVID-19 outcomes in patients with cancer. The FLARE score, derived from circulating inflammatory markers, emerges as an easy-to-use, globally accessible, effective tool for clinicians to identify patients with cancer at heightened risk of severe COVID-19 complications and early mortality who might benefit most from immediate and intensive treatment strategies. Furthermore, our findings underscore the significance of immature neutrophils in the progression of COVID-19 in patients with cancer, advocating for further investigation into how these cells contribute to both cancer and COVID-19 disease.E.S. was supported by the Contracte Clínic Recerca “Emili Letang i Josep Font” 2022 and I Predoctoral Grant in Precision Oncology, 2022 (Cátedra UB IOP). L.M. received funding from the Beca SEOM retorno 2019; ESMO fellowship 2019–2021; Contrato Juan Rodes 2020 (ISCIII, Ministry of Health; JR20/00019); Ayuda Juan Rodés SEOM 2020; Ayuda de la Acción Estratégica en Salud—ISCIII FIS 2021 (PI21/01653); Beca SEOM para Proyectos de Investigación en Immunoncología 2021; Beca SEOM-ASTRAZENECA para Proyectos de Investigación para Grupo Emergente 2022; RADONORM, funded by the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement No. 900009; Grupo Español de Tumores Huérfanos e infrecuentes (GETHI), Convocatoria Inés de Pablo Llorens 2023; and Becas Gilead a la Investigación Biomédica 2023. A.P. received funding from the Fundación CRIS contra el cáncer PR_EX_2021–14, Agència de Gestó d’Ajuts Universitaris i de Recerca 2021 SGR 01156, Fundación Fero BECA ONCOXXI21, Instituto de Salud Carlos III PI22/01017, Asociación Cáncer de Mama Metastásico IV Premios M. Chiara Giorgetti, Breast Cancer Research Foundation BCRF-23–198, and RESCUER, funded by the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement No. 847912. Any views, opinions, findings, conclusions, or recommendations expressed in this material are those solely of the authors and do not necessarily reflect those of funding entities. The preliminary results of this study were presented at ESMO Congress 2020 [38] and ASCO 2022 [39] as poster communications. During the preparation of this work, the author(s) used ChatGPT4 in the writing process. After using this tool, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the publication
Ucraïna, mon amour de Carles Torner o la (auto)traducció com un acte d'amor
No full textThis article aims to analyze Ucraïna, mon amour (Torner, 2023), a novel featuring the Catalan translator of I. B. Singer as a paradigmatic example of the so-called «transfiction». Singer’s presence, also portrayed as a character within the fiction, allows for a profound reflection on the intimate link between writing and translation, concurrently connecting the various 20th-century exiles with the current war in Ukraine. The
analysis focuses on the multiple meanings and metaphors associated with translation, such as cultural bridge, journey, exile, survival, resistance, and, above all, love. Through the literary motif of translation, the intertextual dialogues with the works of the writer in Yiddish and other authors, including Carles Torner, will be explored. The article also examines different translation scenes that unfold throughout the novel
Interpretando a la femme fatale bajo la censura: la performance y star image de las actrices que encarnaron el arquetipo en el cine español del franquismo (1950-1975)
No full textEn la década de los 50 se inicia en España la producción de un cine criminal hecho a imitación del film noir hollywoodiense. Uno de los elementos que se incorpora de dicha cinematografía es el arquetipo de la femme fatale, interpretado por actrices como Katia Loritz o Emma Penella. En los 60, esta corriente cinematográfica deriva en otros géneros como la comedia criminal, donde hace su aparición la femme fatale paródica. En esta tesis doctoral, inscrita en el marco metodológico de los star studies, se analizará la performance y la star image de las actrices que encarnaron el arquetipo en el cine y comedia criminal españoles entre 1950 y 1975. Esto nos permitirá entender cómo las actrices encarnaron el arquetipo en la cinematografía española y qué suponía para la época el ser asociadas a un tipo de feminidad desaconsejable y denostada por el régimen franquista.In Spanish cinema of the 1950s, the criminal film genre started imitating Hollywood’s film noir. The femme fatale archetype is one of the elements adopted from this cinematography, portrayed by actresses such as Katia Loritz and Emma Penella. In the 1960s, criminal cinema evolved into other genres, including criminal comedy, in which the parodic femme fatale makes its appearance. This doctoral thesis, situated within the methodological framework of star studies, analyzes the performance and star image of the actresses who embodied this archetype in Spanish crime and criminal comedy films between 1950 and 1975. It will study how these actresses represented the archetype in Spanish cinema and what it meant at the time to be associated with a form of femininity that was deemed undesirable by the Francoist regime.Programa de Doctorat en Comunicaci
OKRs en la gestión estratégica: un enfoque evolutivo y un modelo integrado para su implementación
No full textTreball de Fi de Grau en Administració i Direcció d'Empreses. Curs 2024-2025Tutora: Enrica Mercè Bornao BarcelóEste estudio analiza los factores clave que determinan la efectividad de los Objetivos y Resultados Clave (Objectives and Key Results, Os y KRs; en adelante, OKRs), en la gestión estratégica. A través de una revisión sistemática de literatura, combinada con un enfoque progresivo de estructuración evolutiva y un proceso de síntesis y generación de nuevo conocimiento, se han identificado los elementos esenciales para su
implementación. Se presentan hallazgos sobre la alineación organizativa, la influencia de la cultura empresarial y la diferenciación entre modelos clásicos y modernos de OKRs. Como contribución, se desarrolla el Modelo Integrado Mintzberg y OKRs (MIMO), proporcionando un marco analítico para optimizar la gestión por objetivos en entornos dinámicos. Se concluye que los OKRs potencian la planificación estratégica al combinar flexibilidad, índices de cumplimiento estratégico y adaptación organizativa
The role of the γ-TuRC subunit GCP8 in microtubule regulation and cytoskeleton organization
No full textMicrotubules (MTs) are part of the cytoskeleton in eukaryotic cells and are nucleated by the γ-tubulin ring complex (γTuRC), at the centrosome, which is also called the MTOC (microtubule organizing centers). The subunit Mozart2/GCP8 is not required for γTuRC assembly/stability and has no obvious role in mitotic spindle assembly. As part of my PhD thesis project I tried to shed light on the role of GCP8 and it’s interphase function in cytoskeleton organization.
I was able to further characterise GCP8 as a subunit and it’s γTuRC independent role. I provided a deeper insight into non-centrosomal/non-mitotic γTuRC functions and the organization/regulation of the interphase microtubule network. Further more I might implicate an additional function of GCP8 in cell attachment/migration and cancer cell migration.Los Microtúbulos (MTs) son parte del citoesqueleto en las células eucariotas y son nucleados por el complejo de la γ-tubulina (γTuRC) en el centrosoma, el cual es conocido como MTOC (centro organizador de microtúbulos). La subunidad Mozart2/GCP8 no se necesita para la formación/estabilidad del γTuRC y no parece jugar un papel evidente durante la formación del uso mitótico. Como parte de mi proyecto de tesis he caracterizado el papel de la GCP8 en la organización del citoesqueleto en interfase. También, he descrito la función de GCP8 tanto asociada al γTuRC como independiente del complejo. Así como las funciones no centrosomales/no mitóticas del γTuRC y la organización/regulación de la red del citoesqueleto durante la interfase. Además demostré que GCP8 esta relacionada con la función de adhesión y migración celular, incluida la migración celular en cáncer.Programa de doctorat en Biomedicin
Development of prognostic models for resected distal cholangiocarcinoma
No full textDistal cholangiocarcinoma is a biliary malignancy associated with poor oncological outcomes with a 5-year survival rate after surgery from 16% to 39.5%.
There’s an urgent need to develop a valid prognostic model that assesses the clinical implications of combination of prognostic indicators for resected distal cholangiocarcinoma, identifying high-risk patients for recurrence.
This doctoral thesis is based on two published articles.
For the first study, we have developed a nomogram integrating independent prognostic factors to create a prognostic model for recurrence-free survival in distal cholangiocarcinoma.
For the second study, A LASSO-regularized Cox regression model was employed for feature selection, examining coefficients' paths and creating a model to predict recurrence. Additionally, a web application was developed to enhance the clinical use of the algorithm.El colangiocarcinoma distal és una neoplàsia maligna d’origen biliar associada a mals resultats oncològics amb una taxa de supervivència a 5 anys després de la cirurgia del 16% al 39,5%.
Hi ha una necessitat urgent de desenvolupar un model pronòstic que avaluï les implicacions clíniques de la combinació d'indicadors pronòstics per al colangiocarcinoma distal ressecat, identificant aquells pacients amb alt risc de recurrència.
Aquesta tesi doctoral es basa en dos articles publicats.
En el primer estudi vam desenvolupar un nomograma integrant els factors pronòstics independents per crear un model pronòstic de la supervivència lliure de recurrència del colangiocarcinoma distal.
Per al segon estudi, vam confeccionar un model de regressió de Cox regularitzat amb LASSO per a la selecció de les variables, examinant els coeficients de cadascuna i creant un model per predir la recurrència. A més, vam desenvolupar una aplicació web per millorar l'ús clínic de l'algoritme.Programa de Doctorat en Biomedicin